6ECA
| Lactobacillus rhamnosus Beta-glucuronidase | Descriptor: | Beta-glucuronidase, CHLORIDE ION, GLYCEROL | Authors: | Biernat, K.A, Pellock, S.J, Bhatt, A.P, Bivins, M.M, Walton, W.G, Tran, B.N.T, Wei, L, Snider, M.C, Cesmat, A.P, Tripathy, A, Erie, D.A, Redinbo, M.R.R. | Deposit date: | 2018-08-07 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.853 Å) | Cite: | Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
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6CXS
| Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine | Descriptor: | 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, Beta-glucuronidase, Maltose/maltodextrin-binding periplasmic protein | Authors: | Wallace, B.D, Redinbo, M.R. | Deposit date: | 2018-04-04 | Release date: | 2019-04-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy. Proc.Natl.Acad.Sci.USA, 2020
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8UGT
| E. eligens beta-glucuronidase bound to UNC10206581-G | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(methylamino)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinoline, Beta-glucuronidase, GLYCEROL, ... | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-10-06 | Release date: | 2024-07-24 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Advanced piperazine-containing inhibitors target microbial beta-glucuronidases linked to gut toxicity. Rsc Chem Biol, 5, 2024
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6ED2
| Faecalibacterium prausnitzii beta-glucuronidase | Descriptor: | FORMIC ACID, GLYCEROL, Glycosyl hydrolase family 2, ... | Authors: | Pellock, S.J, Biernat, K.A, Redinbo, M.R. | Deposit date: | 2018-08-08 | Release date: | 2019-02-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
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6ED1
| Bacteroides dorei Beta-glucuronidase | Descriptor: | Glycosyl hydrolase family 2, sugar binding domain protein, SODIUM ION | Authors: | Biernat, K.A, Redinbo, M.R. | Deposit date: | 2018-08-08 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
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6EC6
| Ruminococcus gnavus Beta-glucuronidase | Descriptor: | Beta-glucuronidase, CHLORIDE ION, GLYCEROL | Authors: | Biernat, K.A, Redinbo, M.R. | Deposit date: | 2018-08-07 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
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6NZG
| Bacteroides uniformis beta-glucuronidase 2 covalently bound to cyclophellitol-6-carboxylate aziridine | Descriptor: | (1S,2R,3S,4S,5S,6R)-2-amino-3,4,5,6-tetrahydroxycyclohexane-1-carboxylic acid, Beta-galactosidase, CALCIUM ION, ... | Authors: | Pellock, S.J, Jariwala, P.B, Redinbo, M.R. | Deposit date: | 2019-02-13 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. Acs Chem.Biol., 15, 2020
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8GEN
| E. eligens beta-glucuronidase bound to UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GEQ
| E. eligens beta-glucuronidase bound to ceritinib-glucuronide | Descriptor: | 4-amino-5-chloro-2-{4-(1-beta-D-glucopyranuronosylpiperidin-4-yl)-5-methyl-2-[(propan-2-yl)oxy]anilino}pyrimidine, Beta-glucuronidase | Authors: | Simpson, J.B, Kowalewski, M.K, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GES
| R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GER
| E. eligens beta-glucuronidase bound to norquetiapine-glucuronide | Descriptor: | 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, Beta-glucuronidase | Authors: | Simpson, J.B, Lietzan, A.D, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GEO
| E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide | Descriptor: | 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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8GET
| R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide | Descriptor: | 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
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5UJ6
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