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2ASM
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BU of 2asm by Molmil
Structure of Rabbit Actin In Complex With Reidispongiolide A
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I.
Deposit date:2005-08-23
Release date:2005-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity
Proc.Natl.Acad.Sci.Usa, 102, 2005
2ASP
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BU of 2asp by Molmil
Structure of Rabbit Actin In Complex With Reidispongiolide C
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I.
Deposit date:2005-08-23
Release date:2005-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity
Proc.Natl.Acad.Sci.Usa, 102, 2005
2Q0R
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BU of 2q0r by Molmil
Structure of Pectenotoxin-2 Bound to Actin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ...
Authors:Allingham, J.S, Miles, C.O, Rayment, I.
Deposit date:2007-05-22
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural basis for regulation of actin polymerization by pectenotoxins.
J.Mol.Biol., 371, 2007
2Q0U
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BU of 2q0u by Molmil
Structure of Pectenotoxin-2 and Latrunculin B Bound to Actin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ...
Authors:Allingham, J.S, Miles, C.O, Rayment, I.
Deposit date:2007-05-22
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A structural basis for regulation of actin polymerization by pectenotoxins.
J.Mol.Biol., 371, 2007
1S22
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BU of 1s22 by Molmil
Absolute Stereochemistry of Ulapualide A
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Allingham, J.S, Tanaka, J, Marriott, G, Rayment, I.
Deposit date:2004-01-07
Release date:2004-02-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Absolute stereochemistry of ulapualide A
Org.Lett., 6, 2004
2ASO
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BU of 2aso by Molmil
Structure of Rabbit Actin In Complex With Sphinxolide B
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Allingham, J.S, Zampella, A, D'Auria, M.V, Rayment, I.
Deposit date:2005-08-23
Release date:2005-10-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity
Proc.Natl.Acad.Sci.Usa, 102, 2005
1YV3
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BU of 1yv3 by Molmil
The structural basis of blebbistatin inhibition and specificity for myosin II
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Allingham, J.S, Smith, R, Rayment, I.
Deposit date:2005-02-14
Release date:2005-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis of blebbistatin inhibition and specificity for myosin II.
Nat.Struct.Mol.Biol., 12, 2005
2O0A
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BU of 2o0a by Molmil
The structure of the C-terminal domain of Vik1 has a motor domain fold but lacks a nucleotide-binding site.
Descriptor: 1,2-ETHANEDIOL, S.cerevisiae chromosome XVI reading frame ORF YPL253c
Authors:Allingham, J.S, Sproul, L.R, Rayment, I, Gilbert, S.P.
Deposit date:2006-11-27
Release date:2007-03-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site.
Cell(Cambridge,Mass.), 128, 2007
3BZ9
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BU of 3bz9 by Molmil
Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II
Descriptor: (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Allingham, J.S, Rayment, I.
Deposit date:2008-01-17
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
3BZ8
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BU of 3bz8 by Molmil
Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II
Descriptor: (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Allingham, J.S, Rayment, I.
Deposit date:2008-01-17
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
7LFF
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BU of 7lff by Molmil
Crystal structure of the Candida albicans kinesin-8 motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein, MAGNESIUM ION
Authors:Allingham, J.S, Hunter, B.
Deposit date:2021-01-16
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
3M6G
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BU of 3m6g by Molmil
Crystal structure of actin in complex with lobophorolide
Descriptor: (1S,3S,4S,5S,7R,8S,9R,12E,14E,16R,17R,19R)-16-hydroxy-9-{(1S,2S,3S)-2-hydroxy-5-[(2S,4R,6S)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]-1,3-dimethylpentyl}-3,5,7,17-tetramethoxy-8,14-dimethyl-11H-spiro[10,23-dioxabicyclo[17.3.1]tricosa-12,14,20-triene-4,2'-oxiran]-11-one, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Allingham, J.S.
Deposit date:2010-03-15
Release date:2010-09-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two molecules of lobophorolide cooperate to stabilize an actin dimer using both their "ring" and "tail" region.
Chem.Biol., 17, 2010
3BZ7
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BU of 3bz7 by Molmil
Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II
Descriptor: (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Allingham, J.S, Rayment, I.
Deposit date:2008-01-17
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
6W7V
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BU of 6w7v by Molmil
Structure of rabbit actin in complex with truncated analog of Mycalolide B
Descriptor: (1E,3R,4R,5S,6R,9S,10S,12S)-12-[(4-aminobutanoyl)oxy]-1-[ethyl(formyl)amino]-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (2R)-oxolane-2-carboxylate, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Allingham, J.S, Deng, X, Trofimova, D.
Deposit date:2020-03-19
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix.
J.Am.Chem.Soc., 143, 2021
6MGO
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BU of 6mgo by Molmil
Structure of rabbit actin in complex with Mycalolide B
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Allingham, J.S, Trofimova, D.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix.
J.Am.Chem.Soc., 2021
6BBN
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BU of 6bbn by Molmil
Crystal structure of a curved tubulin complex induced by the kinesin-13 Kif2A
Descriptor: DARPin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Allingham, J.S, Trofimova, D.
Deposit date:2017-10-19
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.514 Å)
Cite:Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
Nat Commun, 9, 2018
1QZ6
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BU of 1qz6 by Molmil
Structure of rabbit actin in complex with jaspisamide A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Klenchin, V.A, Allingham, J.S, King, R, Tanaka, J, Marriott, G, Rayment, I.
Deposit date:2003-09-15
Release date:2003-11-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin
Nat.Struct.Biol., 10, 2003
9CRW
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BU of 9crw by Molmil
Crystal structure of the Candida albicans kinesin-8 proximal tail domain
Descriptor: Kinesin-like protein
Authors:Trofimova, D, Doubleday, C, Hunter, B, Serrano Arevalo, J, Davison, E, Wen, E, Munro, K, Allingham, J.S.
Deposit date:2024-07-22
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of the Candida albicans kinesin-8 proximal tail domain
To Be Published
3T0Q
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BU of 3t0q by Molmil
Motor Domain Structure of the Kar3-like kinesin from Ashbya gossypii
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, AGR253Wp, ...
Authors:Duan, D, Hnatchuk, D.J, Brenner, J, Davis, D, Allingham, J.S.
Deposit date:2011-07-20
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the Kar3-like kinesin motor domain from the filamentous fungus Ashbya gossypii.
Proteins, 80, 2012
4GKQ
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BU of 4gkq by Molmil
Structure of the neck and C-terminal motor homology domain of ViK1 from Candida glabrata
Descriptor: SPINDLE POLE BODY-ASSOCIATED PROTEIN VIK1
Authors:Duan, D, Allingham, J.S.
Deposit date:2012-08-13
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Neck Rotation and Neck Mimic Docking in the Noncatalytic Kar3-associated Protein Vik1.
J.Biol.Chem., 287, 2012
4GKP
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BU of 4gkp by Molmil
Structure of the truncated neck and C-terminal motor homology domain of ViK1 from Candida glabrata
Descriptor: Spindle pole body-associated protein VIK1
Authors:Duan, D, Allingham, J.S.
Deposit date:2012-08-13
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Neck Rotation and Neck Mimic Docking in the Noncatalytic Kar3-associated Protein Vik1.
J.Biol.Chem., 287, 2012
4GKR
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BU of 4gkr by Molmil
Structure of the C-terminal motor domain of Kar3 from Candida glabrata
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Duan, D, Allingham, J.S.
Deposit date:2012-08-13
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Neck Rotation and Neck Mimic Docking in the Noncatalytic Kar3-associated Protein Vik1.
J.Biol.Chem., 287, 2012
1QZ5
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BU of 1qz5 by Molmil
Structure of rabbit actin in complex with kabiramide C
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Klenchin, V.A, Allingham, J.S, King, R, Tanaka, J, Marriott, G, Rayment, I.
Deposit date:2003-09-15
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin
Nat.Struct.Biol., 10, 2003
7TQZ
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BU of 7tqz by Molmil
Apo CaKip3[2-482] in complex with a microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ...
Authors:Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H.
Deposit date:2022-01-27
Release date:2022-07-13
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
7TR1
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BU of 7tr1 by Molmil
CaKip3[2-436]-L2-mutant(HsKHC) - AMP-PNP in complex with a microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein,Kinesin-1 heavy chain, ...
Authors:Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H.
Deposit date:2022-01-27
Release date:2022-07-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022

 

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