2PTK
| CHICKEN SRC TYROSINE KINASE | Descriptor: | TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC | Authors: | Williams, J.C, Wierenga, R. | Deposit date: | 1997-06-17 | Release date: | 1997-12-24 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J.Mol.Biol., 274, 1997
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1WP0
| Human SCO1 | Descriptor: | SCO1 protein homolog | Authors: | Williams, J.C, Sue, C, Banting, G.S, Yang, H, Glerum, D.M, Hendrickson, W.A, Schon, E.A. | Deposit date: | 2004-08-27 | Release date: | 2005-01-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Human SCO1: IMPLICATIONS FOR REDOX SIGNALING BY A MITOCHONDRIAL CYTOCHROME c OXIDASE "ASSEMBLY" PROTEIN J.Biol.Chem., 280, 2005
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2PG1
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1YGT
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1AMK
| LEISHMANIA MEXICANA TRIOSE PHOSPHATE ISOMERASE | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, TRIOSE PHOSPHATE ISOMERASE | Authors: | Williams, J.C, Wierenga, R. | Deposit date: | 1997-06-17 | Release date: | 1997-12-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power. Protein Eng., 12, 1999
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5U6A
| CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-PEG3-MEDITOPE | Descriptor: | Heavy Chain, Immunoglobulin G binding protein A, Light Chain, ... | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | Deposit date: | 2016-12-07 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.736 Å) | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-PEG3-Meditope To Be Published
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5U5M
| CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE | Descriptor: | AZIDO-PEG4-MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB, ... | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | Deposit date: | 2016-12-06 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-Meditope To Be Published
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8G2M
| The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer | Descriptor: | CITRIC ACID, Heavy chain of humanized IgG, Light chain of humanized IgG, ... | Authors: | Williams, J.C, Williams, J.C. | Deposit date: | 2023-02-05 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
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8G8N
| CTLA4 Fab with peptide | Descriptor: | CYS-PRO-GLY-LYS-GLY-LEU-PRO-SER-CYS, Fab heavy chain, Fab light chain | Authors: | Williams, J.C. | Deposit date: | 2023-02-18 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
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3GC3
| Crystal Structure of Arrestin2S and Clathrin | Descriptor: | Beta-arrestin-1, Clathrin heavy chain 1 | Authors: | Williams, J.C, Kang, D.S. | Deposit date: | 2009-02-21 | Release date: | 2009-08-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J.Biol.Chem., 284, 2009
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5HPM
| Cetuximab Fab in complex with cyclic linked meditope | Descriptor: | 2-AMINO-3-MERCAPTO-PROPIONAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-01-20 | Release date: | 2016-06-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5HYQ
| Cetuximab Fab in complex with amidated meditope | Descriptor: | Amidated meditope, Cetuximab heavy chain, Cetuximab light chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-02-01 | Release date: | 2016-06-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.477 Å) | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5I2I
| Structure of cetuximab Fab with cyclic F3Q variant of the meditope | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, Meditope, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-02-08 | Release date: | 2016-10-26 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.551 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ICX
| Cetuximab Fab in complex with CQFDLSTRRLRCGGSK meditope | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-02-23 | Release date: | 2016-06-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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4KAQ
| Structure of rituximab Fab | Descriptor: | Rituximab heavy chain, Rituximab light chain | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2013-04-22 | Release date: | 2014-12-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal structure of rituximab To be Published
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1JDL
| Structure of cytochrome c2 from Rhodospirillum Centenum | Descriptor: | CYTOCHROME C2, ISO-2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Camara-Artigas, A, Williams, J.C, Allen, J.P. | Deposit date: | 2001-06-14 | Release date: | 2001-11-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of cytochrome c2 from Rhodospirillum centenum. Acta Crystallogr.,Sect.D, 57, 2001
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2M02
| 3D structure of cap-gly domain of mammalian dynactin determined by magic angle spinning NMR spectroscopy | Descriptor: | Dynactin subunit 1 | Authors: | Yan, S, Hou, G, Schwieters, C.D, Ahmed, S, Williams, J.C, Polenova, T. | Deposit date: | 2012-10-15 | Release date: | 2013-05-08 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Three-Dimensional Structure of CAP-Gly Domain of Mammalian Dynactin Determined by Magic Angle Spinning NMR Spectroscopy: Conformational Plasticity and Interactions with End-Binding Protein EB1. J.Mol.Biol., 425, 2013
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4Y1L
| Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation | Descriptor: | RWD domain-containing protein 3, SUMO-conjugating enzyme UBC9 | Authors: | Aileen, Y.A, Ambaye, N.D, Li, Y.J, Vega, R, Bzymek, K, Williams, J.C, Hu, W, Chen, Y. | Deposit date: | 2015-02-08 | Release date: | 2015-05-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | RWD Domain as an E2 (Ubc9)-Interaction Module. J.Biol.Chem., 290, 2015
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1JGW
| Photosynthetic Reaction Center Mutant With Thr M 21 Replaced With Leu | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | Authors: | Camara-Artigas, A, Magee, C.L, Williams, J.C, Allen, J.P. | Deposit date: | 2001-06-27 | Release date: | 2001-09-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Individual interactions influence the crystalline order for membrane proteins. Acta Crystallogr.,Sect.D, 57, 2001
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5FF6
| Cetuximab Fab in complex with L10Q meditope variant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-12-17 | Release date: | 2016-10-26 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5EUK
| Cetuximab Fab in complex with F3H meditope variant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-18 | Release date: | 2016-10-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ETU
| Cetuximab Fab in complex with L5E meditope variant | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, L5E meditope variant, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-18 | Release date: | 2016-10-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ESQ
| Cetuximab Fab in complex with cyclic beta-alanine-linked meditope | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, Cyclic beta-alanine-linked meditope, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-16 | Release date: | 2016-06-15 | Last modified: | 2017-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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1JH0
| Photosynthetic Reaction Center Mutant With Glu L 205 Replaced to Leu | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (III) ION, ... | Authors: | Camara-Artigas, A, Magee, C.L, Williams, J.C, Allen, J.P. | Deposit date: | 2001-06-27 | Release date: | 2001-09-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Individual interactions influence the crystalline order for membrane proteins. Acta Crystallogr.,Sect.D, 57, 2001
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1JGZ
| Photosynthetic Reaction Center Mutant With Tyr M 76 Replaced With Lys | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | Authors: | Camara-Artigas, A, Magee, C.L, Williams, J.C, Allen, J.P. | Deposit date: | 2001-06-27 | Release date: | 2001-09-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Individual interactions influence the crystalline order for membrane proteins. Acta Crystallogr.,Sect.D, 57, 2001
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