8FD0
| Crystal structure of bovine rod opsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.71 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
|
|
8FCZ
| Crystal structure of ground-state rhodopsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
|
|
8FQ7
| Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
5VAK
| Crystal Structure of Beta-Klotho, Domain 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
4GGN
| Malaria invasion machinery protein complex | Descriptor: | Myosin A tail domain interacting protein MTIP, Myosin-A | Authors: | Khamrui, S, Turley, S, Bergman, L.W, Hol, W.G.J. | Deposit date: | 2012-08-06 | Release date: | 2013-07-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. Mol.Biochem.Parasitol., 190, 2013
|
|
5VAN
| Crystal Structure of Beta-Klotho | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
5VAQ
| Crystal Structure of Beta-Klotho in Complex with FGF21CT | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
|
|
8CQB
| |
6QNW
| |
4M3J
| Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis | Descriptor: | Camelid heavy-chain antibody variable fragment cAb-H7S, SULFATE ION | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | Deposit date: | 2013-08-06 | Release date: | 2014-08-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
|
|
7Q6Z
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 | Descriptor: | 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-11-09 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
|
|
4M3K
| Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis | Descriptor: | Beta-lactamase, CHLORIDE ION, Camelid heavy-chain antibody variable fragment cAb-H7S | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | Deposit date: | 2013-08-06 | Release date: | 2014-08-06 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
|
|
7RTH
| Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | Deposit date: | 2021-08-13 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
4N1H
| Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis | Descriptor: | Beta-lactamase, Camelid heavy-chain antibody variable fragment cAb-F11N | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | Deposit date: | 2013-10-04 | Release date: | 2014-10-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
|
|
7NVL
| Human TRiC complex in closed state with nanobody bound (Consensus Map) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W, Structural Genomics Consortium (SGC) | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
7NVN
| Human TRiC complex in closed state with nanobody and tubulin bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
7NVO
| Human TRiC complex in open state with nanobody bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
7NVM
| Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Actin, ... | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W, Structural Genomics Consortium (SGC) | Deposit date: | 2021-03-15 | Release date: | 2022-03-02 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nat.Struct.Mol.Biol., 29, 2022
|
|
6GS1
| Crystal structure of peptide transporter DtpA-nanobody in MES buffer | Descriptor: | Dipeptide and tripeptide permease A, Nanobody 00 | Authors: | Ural-Blimke, Y, Flayhan, A, Loew, C, Quistgaard, E.M. | Deposit date: | 2018-06-13 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. J. Am. Chem. Soc., 141, 2019
|
|
6GS4
| Crystal structure of peptide transporter DtpA-nanobody in complex with valganciclovir | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Dipeptide and tripeptide permease A, [(2~{S})-2-[(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)methoxy]-3-oxidanyl-propyl] (2~{S})-2-azanyl-3-methyl-butanoate, ... | Authors: | Ural-Blimke, Y, Flayhan, A, Quistgaard, E.M, Loew, C. | Deposit date: | 2018-06-13 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.645 Å) | Cite: | Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. J. Am. Chem. Soc., 141, 2019
|
|
5DA4
| |
7PQQ
| |
7PQG
| |
5DA0
| Structure of the the SLC26 transporter SLC26Dg in complex with a nanobody | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Nanobody, Sulphate transporter | Authors: | Dutzler, R, Geertsma, E.R, Chang, Y, Shaik, F.R. | Deposit date: | 2015-08-19 | Release date: | 2015-09-09 | Last modified: | 2015-10-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat.Struct.Mol.Biol., 22, 2015
|
|
7Q1U
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map) | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
|
|