8SO9
| Phosphoinositide phosphate 3 kinase gamma | Descriptor: | Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | Authors: | Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2023-04-28 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SOA
| Phosphoinositide phosphate 3 kinase gamma bound with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | Authors: | Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2023-04-28 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SOE
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8SOD
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8SOC
| Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2023-04-28 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SOB
| Phosphoinositide phosphate 3 kinase gamma bound with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase | Authors: | Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2023-04-28 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
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8SL3
| Human adenylyl Cyclase 5 in complex with Gbg | Descriptor: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yen, Y.C, Tesmer, J.J.G. | Deposit date: | 2023-04-20 | Release date: | 2024-04-03 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 2024
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5H7K
| Crystal structure of Elongation factor 2 GDP-form | Descriptor: | Elongation factor 2, GUANOSINE-5'-DIPHOSPHATE | Authors: | Tanzawa, T, Kato, K, Uchiumi, T, Yao, M. | Deposit date: | 2016-11-18 | Release date: | 2018-02-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion Nucleic Acids Res., 46, 2018
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5H7L
| Complex of Elongation factor 2-50S ribosomal protein L12 | Descriptor: | 50S ribosomal protein L12, Elongation factor 2, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Tanzawa, T, Kato, K, Uchiumi, T, Yao, M. | Deposit date: | 2016-11-18 | Release date: | 2018-02-21 | Last modified: | 2018-05-02 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion Nucleic Acids Res., 46, 2018
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5H7J
| Crystal structure of Elongation factor 2 | Descriptor: | Elongation factor 2, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Tanzawa, T, Kato, K, Uchiumi, T, Yao, M. | Deposit date: | 2016-11-18 | Release date: | 2018-02-21 | Last modified: | 2018-05-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion Nucleic Acids Res., 46, 2018
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8H1L
| Crystal structure of glucose-2-epimerase in complex with D-Glucitol from Runella slithyformis Runsl_4512 | Descriptor: | N-acylglucosamine 2-epimerase, sorbitol | Authors: | Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M. | Deposit date: | 2022-10-03 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023
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8H1K
| Crystal structure of glucose-2-epimerase from Runella slithyformis Runsl_4512 | Descriptor: | FORMIC ACID, GLYCEROL, N-acylglucosamine 2-epimerase | Authors: | Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M. | Deposit date: | 2022-10-03 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023
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8H1M
| Crystal structure of glucose-2-epimerase mutant_D254A from Runella slithyformis Runsl_4512 | Descriptor: | FORMIC ACID, N-acylglucosamine 2-epimerase | Authors: | Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M. | Deposit date: | 2022-10-03 | Release date: | 2023-07-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023
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8H1N
| Crystal structure of glucose-2-epimerase mutant_D254A in complex with D-Glucitol from Runella slithyformis Runsl_4512 | Descriptor: | FORMIC ACID, N-acylglucosamine 2-epimerase, sorbitol | Authors: | Wang, H, Sun, X.M, Saburi, W, Yu, J, Yao, M. | Deposit date: | 2022-10-03 | Release date: | 2023-07-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta Crystallogr D Struct Biol, 79, 2023
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3AX3
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3AX2
| Crystal structure of rat TOM20-ALDH presequence complex: a disulfide-tethered complex with a non-optimized, long linker | Descriptor: | Aldehyde dehydrogenase, mitochondrial, Mitochondrial import receptor subunit TOM20 homolog, ... | Authors: | Saitoh, T, Maita, Y, Kohda, D. | Deposit date: | 2011-03-28 | Release date: | 2011-07-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides. Biochemistry, 50, 2011
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3AX5
| Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions. | Descriptor: | Aldehyde dehydrogenase, mitochondrial, Mitochondrial import receptor subunit TOM20 homolog, ... | Authors: | Saitoh, T, Maita, Y, Kohda, D. | Deposit date: | 2011-03-29 | Release date: | 2011-07-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides. Biochemistry, 50, 2011
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1B41
| HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | Authors: | Kryger, G, Harel, M, Shafferman, A, Silman, I, Sussman, J.L. | Deposit date: | 1999-01-05 | Release date: | 2001-01-17 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr.,Sect.D, 56, 2000
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1B7X
| STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE | Descriptor: | PROTEIN (INHIBITOR), PROTEIN (THROMBIN HEAVY CHAIN), PROTEIN (THROMBIN LIGHT CHAIN) | Authors: | Caccia, S, Futterer, K, Di Cera, E, Waksman, G. | Deposit date: | 1999-01-25 | Release date: | 1999-03-02 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unexpected crucial role of residue 225 in serine proteases. Proc.Natl.Acad.Sci.USA, 96, 1999
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6LFE
| Rat-COMT, Nitecapone,SAM and Mg bond | Descriptor: | 3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,4-dione, Catechol O-methyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Takebe, K, Iijima, H, Suzuki, M. | Deposit date: | 2019-12-02 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone. Chem Pharm Bull (Tokyo), 68, 2020
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3J26
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4Z2G
| Serratia marcescens Chitinase B complexed with macrolide inhibitor 26 | Descriptor: | (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ethyl-2,10-dihydroxy-2,6,8,10,12,15,15,17-octamethyl-5-oxo-9-(prop-2-yn-1-yloxy)-4,14,16-trioxabicyclo[11.3.1]heptadec-7-yl {4-[N'-(methylcarbamoyl)carbamimidamido]butyl}carbamate, Chitinase B | Authors: | Maita, N, Sugawara, A, Sunazuka, T. | Deposit date: | 2015-03-30 | Release date: | 2015-07-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase J.Med.Chem., 58, 2015
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4Z2L
| Serratia marcescens Chitinase B complexed with macrolide inhibitor 33 | Descriptor: | (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-14-ethyl-7,10,12,13-tetrahydroxy-3,5,7,9,11,13-hexamethyl-2-oxo-6-(prop-2-yn-1-yloxy)oxacyclotetradecan-4-yl {3-[N'-(methylcarbamoyl)carbamimidamido]propyl}carbamate, CHLORIDE ION, Chitinase B, ... | Authors: | Maita, N, Sugawara, A, Sunazuka, T. | Deposit date: | 2015-03-30 | Release date: | 2015-07-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase J.Med.Chem., 58, 2015
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4Z2J
| Serratia marcescens Chitinase B complexed with macrolide inhibitor 31 | Descriptor: | (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ethyl-2,10-dihydroxy-2,6,8,10,12,15,15,17-octamethyl-5-oxo-9-(prop-2-yn-1-yloxy)-4,14,16-trioxabicyclo[11.3.1]heptadec-7-yl {5-[N'-(methylcarbamoyl)carbamimidamido]pentyl}carbamate, Chitinase B, GLYCEROL, ... | Authors: | Maita, N, Sugawara, A, Sunazuka, T. | Deposit date: | 2015-03-30 | Release date: | 2015-07-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase J.Med.Chem., 58, 2015
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7AKW
| Crystal structure of the viral rhodopsins chimera O1O2 | Descriptor: | EICOSANE, RETINAL, chimera of viral rhodopsins OLPVR1 and OLPVRII | Authors: | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | Deposit date: | 2020-10-02 | Release date: | 2020-11-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Viral rhodopsins 1 are an unique family of light-gated cation channels. Nat Commun, 11, 2020
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