3UCB
| Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | Authors: | Agniswamy, J, Chen-Hsiang, S, Aniana, A, Sayer, J.M, Louis, J.M, Weber, I.T. | Deposit date: | 2011-10-26 | Release date: | 2012-03-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements. Biochemistry, 51, 2012
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6K4Z
| Single-chain Fv antibody of C6 COMPLEXED WITH 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID | Descriptor: | 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID, GLYCEROL, SULFATE ION, ... | Authors: | Nishiguchi, A, Numoto, N, Ito, N, Azuma, T, Oda, M. | Deposit date: | 2019-05-27 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain. Mol.Immunol., 114, 2019
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3UQN
| Crystal structure of dihydrodipicolinate synthase from Acinetobacter baumannii complexed with Oxamic acid at 1.9 Angstrom resolution | Descriptor: | Dihydrodipicolinate synthase, GLYCEROL, OXAMIC ACID | Authors: | Singh, A, Kaushik, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-11-21 | Release date: | 2011-12-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structure of dihydrodipicolinate synthase from Acinetobacter baumannii complexed with Oxamic acid at 1.9 Angstrom resolution To be Published
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6K53
| A variant of metagenome-derived GH6 cellobiohydrolase, HmCel6A (P88S/L230F/F414S) | Descriptor: | CITRATE ANION, GH6 cellobiohydrolase, HMCEL6A, ... | Authors: | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | Deposit date: | 2019-05-28 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A hyperthermophilic GH6 cellobiohydrolase (HmCel6A) from a hot spring metagenomic data To Be Published
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3UF5
| Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine | Descriptor: | CALCIUM ION, Macrophage colony-stimulating factor 1 | Authors: | Elegheert, J, Bracke, N, Bekaert, A, Savvides, S.N. | Deposit date: | 2011-10-31 | Release date: | 2012-08-22 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1 Nat.Struct.Mol.Biol., 19, 2012
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3UFN
| Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, HIV-1 protease | Authors: | Agniswamy, J, Chen-Hsiang, S, Aniana, A, Sayer, J.M, Louis, J.M, Weber, I.T. | Deposit date: | 2011-11-01 | Release date: | 2012-03-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements. Biochemistry, 51, 2012
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6KKW
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3H7N
| Structure of Nup120 | Descriptor: | Nucleoporin NUP120 | Authors: | Seo, H.S, Ma, Y, Debler, E.W, Blobel, G, Hoelz, A. | Deposit date: | 2009-04-27 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc.Natl.Acad.Sci.USA, 106, 2009
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3H9Q
| Crystal structure of E. coli MccB + SeMet MccA | Descriptor: | MccB protein, Microcin C7 ANALOG, SULFATE ION, ... | Authors: | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | Deposit date: | 2009-04-30 | Release date: | 2009-06-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3UF0
| Crystal structure of a putative NAD(P) dependent gluconate 5-dehydrogenase from Beutenbergia cavernae(EFI target EFI-502044) with bound NADP (low occupancy) | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR | Authors: | Vetting, M.W, Toro, R, Bhosle, R, Hillerich, B, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2011-10-31 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a putative NAD(P) dependent gluconate 5-dehydrogenase from Beutenbergia cavernae(EFI target EFI-502044) with bound NADP (low occupancy) To be Published
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3UJ6
| SeMet Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with SAM and PO4 | Descriptor: | PHOSPHATE ION, Phosphoethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2012-03-21 | Method: | X-RAY DIFFRACTION (1.974 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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6KJN
| The microtubule-binding domains of yeast cytoplasmic dynein in the high affinity state | Descriptor: | Dynein heavy chain, cytoplasmic | Authors: | Nishida, N, Komori, Y, Takarada, O, Watanabe, A, Tamura, S, Kubo, S, Shimada, I, Kikkawa, M. | Deposit date: | 2019-07-22 | Release date: | 2020-03-18 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis for two-way communication between dynein and microtubules. Nat Commun, 11, 2020
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3HFN
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3HFR
| Crystal structure of glutamate racemase from Listeria monocytogenes | Descriptor: | CHLORIDE ION, Glutamate racemase, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | Authors: | Majorek, K.A, Chruszcz, M, Zimmerman, M.D, Klimecka, M.M, Cymborowski, M, Skarina, T, Onopriyenko, O, Stam, J, Otwinowski, Z, Anderson, W.F, Savchenko, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-05-12 | Release date: | 2009-06-09 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of glutamate racemase from Listeria monocytogenes TO BE PUBLISHED
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6KFF
| Undocked INX-6 hemichannel in a nanodisc | Descriptor: | Innexin-6 | Authors: | Burendei, B, Shinozaki, R, Watanabe, M, Terada, T, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2019-07-07 | Release date: | 2020-02-12 | Last modified: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Sci Adv, 6, 2020
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3UJD
| Phosphoethanolamine methyltransferase mutant (Y19F) from Plasmodium falciparum in complex with phosphocholine | Descriptor: | PHOSPHOCHOLINE, Phosphoethanolamine N-methyltransferase | Authors: | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | Deposit date: | 2011-11-07 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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3HID
| Crystal structure of adenylosuccinate synthetase from Yersinia pestis CO92 | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Adenylosuccinate synthetase | Authors: | Zhang, R, Zhou, M, Peterson, S, Anderson, W, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-05-19 | Release date: | 2009-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of the adenylosuccinate synthetase from Yersinia pestis CO92 To be Published
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6KB6
| X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA) co-crystals obtained by delipidation and cross-seeding | Descriptor: | 2-tetradecylsulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. | Deposit date: | 2019-06-24 | Release date: | 2020-11-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.431 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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3HH7
| Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) | Descriptor: | Muscarinic toxin-like protein 3 homolog | Authors: | Roy, A, Zhou, X, Chong, M.Z, D'hoedt, D, Foo, C.S, Rajagopalan, N, Nirthanan, S, Bertrand, D, Sivaraman, J, Kini, R.M. | Deposit date: | 2009-05-15 | Release date: | 2010-01-12 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) J.Biol.Chem., 285, 2010
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3UM9
| Crystal Structure of the Defluorinating L-2-Haloacid Dehalogenase Bpro0530 | Descriptor: | Haloacid dehalogenase, type II, NICKEL (II) ION, ... | Authors: | Chan, P.W.Y, Savchenko, A, Yakunin, A.F, Edwards, E.A, Pai, E.F. | Deposit date: | 2011-11-12 | Release date: | 2012-11-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structural adaptations of L-2-haloacid dehalogenases that enable hydrolytic defluorination To be Published
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3UV7
| Ec_IspH in complex with buta-2,3-dienyl diphosphate (1300) | Descriptor: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, buta-2,3-dien-1-yl trihydrogen diphosphate | Authors: | Span, I, Wang, K, Wang, W, Zhang, Y, Bacher, A, Eisenreich, W, Schulz, C, Oldfield, E, Groll, M. | Deposit date: | 2011-11-29 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of acetylene hydratase activity of the iron-sulphur protein IspH. Nat Commun, 3, 2012
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3UWZ
| Crystal structure of Staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate | Descriptor: | 2-HYDROXY-1-(HYDROXYMETHYL)ETHYL DIHYDROGEN PHOSPHATE, PHOSPHATE ION, Triosephosphate isomerase | Authors: | Mukherjee, S, Roychowdhury, A, Dutta, D, Das, A.K. | Deposit date: | 2011-12-03 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of triosephosphate isomerase from methicillin resistant Staphylococcus aureus MRSA252 provide structural insights into novel modes of ligand binding and unique conformations of catalytic loop Biochimie, 94, 2012
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3UYP
| Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Envelope protein, GLYCEROL, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-06 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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3UZE
| Crystal structure of the dengue virus serotype 3 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Envelope protein, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-07 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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3UC3
| The crystal structure of Snf1-related kinase 2.3 | Descriptor: | COBALT (II) ION, Serine/threonine-protein kinase SRK2I | Authors: | Zhou, X.E, Ng, L.-M, Soon, F.-F, Kovach, A, Suino-Powell, K.M, Li, J, Melcher, K, Xu, H.E. | Deposit date: | 2011-10-25 | Release date: | 2011-12-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases. Proc.Natl.Acad.Sci.USA, 108, 2011
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