7T4E
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7T4D
| Pore structure of pore-forming toxin Epx4 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Epx4 | Authors: | Xiong, X.Z, Dong, M, Yang, P, Abraham, J. | Deposit date: | 2021-12-09 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell, 185, 2022
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8YBR
| Choline transporter BetT | Descriptor: | BCCT family transporter | Authors: | Yang, T.J, Nian, Y.W, Lin, H.J, Li, J, Zhang, J.R, Fan, M.R. | Deposit date: | 2024-02-16 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structure and mechanism of the osmoregulated choline transporter BetT. Sci Adv, 10, 2024
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4OU4
| Crystal structure of esterase rPPE mutant S159A complexed with (S)-Ac-CPA | Descriptor: | (2S)-(acetyloxy)(2-chlorophenyl)ethanoic acid, Alpha/beta hydrolase fold-3 domain protein | Authors: | Dou, S, Kong, X.D, Ma, B.D, Xu, J.H, Zhou, J.H. | Deposit date: | 2014-02-15 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition Biochem.Biophys.Res.Commun., 446, 2014
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4ORD
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4DCH
| Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations | Descriptor: | (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... | Authors: | Greasley, S.E, Hickey, M, Feng, J, Garcia, E. | Deposit date: | 2012-01-17 | Release date: | 2012-02-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
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7ML7
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7MLH
| Crystal structure of human IgE (2F10) in complex with Der p 2.0103 | Descriptor: | CHLORIDE ION, Der p 2 variant 3, IgE Heavy chain, ... | Authors: | Khatri, K, Kapingidza, A.B, Richardson, C.M, Vailes, L.D, Wunschmann, S, Dolamore, C, Chapman, M.D, Smith, S.A, Pomes, A, Chruszcz, M. | Deposit date: | 2021-04-28 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxis in vivo. Pnas Nexus, 1, 2022
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8VTT
| Meis1 homeobox domain bound to neomycin fragment | Descriptor: | Homeobox protein Meis1, RIBOSTAMYCIN, SULFATE ION | Authors: | Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N, Sadek, H.A. | Deposit date: | 2024-01-27 | Release date: | 2024-02-14 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Identification of FDA-approved drugs that induce heart regeneration in mammals. Nat Cardiovasc Res, 3, 2024
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8VTS
| Meis1 homeobox domain bound to paromomycin fragment | Descriptor: | 1,2-ETHANEDIOL, Homeobox protein Meis1, ISOPROPYL ALCOHOL, ... | Authors: | Tomchick, D.R, Ahmed, M.S, Nguyen, N.U.N. | Deposit date: | 2024-01-27 | Release date: | 2024-02-14 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Identification of FDA-approved drugs that induce heart regeneration in mammals. Nat Cardiovasc Res, 3, 2024
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8W6A
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8W6B
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5GH9
| Crystal structure of CBP Bromodomain with H3K56ac peptide | Descriptor: | CREB-binding protein, Histone H3 | Authors: | Xu, L. | Deposit date: | 2016-06-19 | Release date: | 2017-06-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac FEBS J., 2017
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7YLM
| Cryo-EM structure of 8-subunit Smc5/6 hinge region | Descriptor: | MMS21 isoform 1, SMC6 isoform 1, Structural maintenance of chromosomes protein 5 | Authors: | Qian, L, Jun, Z, Xiang, Z, Wang, Z, Tong, C, Duo, J, Zhenguo, C, Wang, L. | Deposit date: | 2022-07-26 | Release date: | 2024-01-31 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6.17 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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7YQH
| Cryo-EM structure of 8-subunit Smc5/6 | Descriptor: | DNA repair protein KRE29, E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 3, ... | Authors: | Qian, L, Jun, Z, Xiang, Z, Tong, C, Zhaoning, W, Duo, J, Zhenguo, C, Lanfeng, W. | Deposit date: | 2022-08-07 | Release date: | 2024-01-31 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8WUL
| Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | Descriptor: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen, ... | Authors: | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | Deposit date: | 2023-10-20 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
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8WTE
| Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | Descriptor: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen (Fragment), ... | Authors: | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | Deposit date: | 2023-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen. Commun Biol, 7, 2024
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8YBQ
| Choline transporter BetT - CHT bound | Descriptor: | BCCT family transporter, CHOLINE ION | Authors: | Yang, T.J, Nian, Y.W, Lin, H.J, Li, J, Zhang, J.R, Fan, M.R. | Deposit date: | 2024-02-16 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Structure and mechanism of the osmoregulated choline transporter BetT. Sci Adv, 10, 2024
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2NB4
| Solution structure of Q388A3 PDZ domain | Descriptor: | Putative uncharacterized protein | Authors: | Mei, S. | Deposit date: | 2016-01-24 | Release date: | 2016-02-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of Q388A3 PDZ domain from Trypanosoma brucei J.Struct.Biol., 194, 2016
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2N7S
| Solution Structure of Leptospiral LigA4 Big Domain | Descriptor: | Ig-like repeat domain protein 1 | Authors: | Mei, S. | Deposit date: | 2015-09-17 | Release date: | 2015-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of leptospiral LigA4 Big domain. Biochem. Biophys. Res. Commun., 467, 2015
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6KDY
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2MQG
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6KE3
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6KDF
| Crystal structure of the alpha beta heterodimer of human IDH3 in APO form. | Descriptor: | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta | Authors: | Sun, P, Ding, J. | Deposit date: | 2019-07-02 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase. J.Biol.Chem., 294, 2019
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8JHZ
| Cryo-EM structure of the TcsH-TMPRSS2 complex | Descriptor: | Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION | Authors: | Zhou, R, Liang, T, Zhan, X. | Deposit date: | 2023-05-25 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin. Nat Commun, 15, 2024
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