1R3J
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![BU of 1r3j by Molmil](/molmil-images/mine/1r3j) | potassium channel KcsA-Fab complex in high concentration of Tl+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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1ORQ
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![BU of 1orq by Molmil](/molmil-images/mine/1orq) | X-ray structure of a voltage-dependent potassium channel in complex with an Fab | Descriptor: | 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ... | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2003-03-14 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray structure of a voltage-dependent K+ channel Nature, 423, 2003
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8EP1
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![BU of 8ep1 by Molmil](/molmil-images/mine/8ep1) | |
8EOW
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![BU of 8eow by Molmil](/molmil-images/mine/8eow) | |
8EP0
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![BU of 8ep0 by Molmil](/molmil-images/mine/8ep0) | |
1R3I
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![BU of 1r3i by Molmil](/molmil-images/mine/1r3i) | potassium channel KcsA-Fab complex in Rb+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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1R3L
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![BU of 1r3l by Molmil](/molmil-images/mine/1r3l) | potassium channel KcsA-Fab complex in Cs+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CESIUM ION, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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1R3K
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![BU of 1r3k by Molmil](/molmil-images/mine/1r3k) | potassium channel KcsA-Fab complex in low concentration of Tl+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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3SYQ
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![BU of 3syq by Molmil](/molmil-images/mine/3syq) | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Whorton, M.R, MacKinnon, R. | Deposit date: | 2011-07-18 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.44 Å) | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.), 147, 2011
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3SPJ
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![BU of 3spj by Molmil](/molmil-images/mine/3spj) | |
3U6N
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![BU of 3u6n by Molmil](/molmil-images/mine/3u6n) | Open Structure of the BK channel Gating Ring | Descriptor: | CALCIUM ION, High-Conductance Ca2+-Activated K+ Channel protein | Authors: | Yuan, P, MacKinnon, R. | Deposit date: | 2011-10-12 | Release date: | 2011-12-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.61 Å) | Cite: | Open structure of the Ca(2+) gating ring in the high-conductance Ca(2+)-activated K(+) channel. Nature, 481, 2011
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3UM7
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![BU of 3um7 by Molmil](/molmil-images/mine/3um7) | |
3SPC
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![BU of 3spc by Molmil](/molmil-images/mine/3spc) | Inward rectifier potassium channel Kir2.2 in complex with dioctanoylglycerol pyrophosphate (DGPP) | Descriptor: | (2R)-3-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate, Inward-rectifier K+ channel Kir2.2, POTASSIUM ION | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.454 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYC
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![BU of 3syc by Molmil](/molmil-images/mine/3syc) | |
3SPG
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![BU of 3spg by Molmil](/molmil-images/mine/3spg) | Inward rectifier potassium channel Kir2.2 R186A mutant in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.613 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SPI
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![BU of 3spi by Molmil](/molmil-images/mine/3spi) | Inward rectifier potassium channel Kir2.2 in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.307 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYA
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![BU of 3sya by Molmil](/molmil-images/mine/3sya) | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | Authors: | Whorton, M.R, MacKinnon, R. | Deposit date: | 2011-07-16 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.), 147, 2011
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3SPH
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![BU of 3sph by Molmil](/molmil-images/mine/3sph) | Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYP
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![BU of 3syp by Molmil](/molmil-images/mine/3syp) | |
3SYO
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![BU of 3syo by Molmil](/molmil-images/mine/3syo) | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION | Authors: | Whorton, M.R, MacKinnon, R. | Deposit date: | 2011-07-18 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.54 Å) | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.), 147, 2011
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2H8P
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![BU of 2h8p by Molmil](/molmil-images/mine/2h8p) | Structure of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB heavy chain, FAB light chain, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-07 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2HFE
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![BU of 2hfe by Molmil](/molmil-images/mine/2hfe) | Rb+ complex of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-23 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2HG5
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![BU of 2hg5 by Molmil](/molmil-images/mine/2hg5) | Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, CESIUM ION, FAB HEAVY CHAIN, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-26 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2IH3
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![BU of 2ih3 by Molmil](/molmil-images/mine/2ih3) | Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | Deposit date: | 2006-09-25 | Release date: | 2006-11-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation. Science, 314, 2006
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8ED7
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![BU of 8ed7 by Molmil](/molmil-images/mine/8ed7) | cryo-EM structure of TRPM3 ion channel in apo state | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Transient receptor potential cation channel, subfamily M, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2022-09-03 | Release date: | 2022-11-02 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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