5KOS
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![BU of 5kos by Molmil](/molmil-images/mine/5kos) | Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-~{tert}-butyl-4-(3-methoxypropylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]pyrimidine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.-C, Lane, W. | Deposit date: | 2016-07-01 | Release date: | 2016-11-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. Acs Med.Chem.Lett., 7, 2016
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5KOT
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![BU of 5kot by Molmil](/molmil-images/mine/5kot) | Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor | Descriptor: | 1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.-C, Lane, W. | Deposit date: | 2016-07-01 | Release date: | 2017-07-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of TAK-272: A Novel, Potent and Orally Active Renin Inhibitor To be published
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1RDV
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![BU of 1rdv by Molmil](/molmil-images/mine/1rdv) | |
3E85
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![BU of 3e85 by Molmil](/molmil-images/mine/3e85) | Crystal Structure of Pathogenesis-related Protein LlPR-10.2B from yellow lupine in complex with Diphenylurea | Descriptor: | 1,3-DIPHENYLUREA, PR10.2B, SODIUM ION | Authors: | Fernandes, H.C, Bujacz, G, Bujacz, A, Sikorski, M.M, Jaskolski, M. | Deposit date: | 2008-08-19 | Release date: | 2009-03-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein. Febs J., 276, 2009
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3IE5
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![BU of 3ie5 by Molmil](/molmil-images/mine/3ie5) | Crystal structure of Hyp-1 protein from Hypericum perforatum (St John's wort) involved in hypericin biosynthesis | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Michalska, K, Fernandes, H, Sikorski, M.M, Jaskolski, M. | Deposit date: | 2009-07-22 | Release date: | 2009-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.688 Å) | Cite: | Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin J.Struct.Biol., 169, 2010
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1OD6
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![BU of 1od6 by Molmil](/molmil-images/mine/1od6) | The Crystal Structure of Phosphopantetheine adenylyltransferase from Thermus Thermophilus in complex with 4'-phosphopantetheine | Descriptor: | 4'-PHOSPHOPANTETHEINE, PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE, SULFATE ION | Authors: | Takahashi, H, Inagaki, E, Miyano, M, Tahirov, T.H. | Deposit date: | 2003-02-13 | Release date: | 2003-03-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure and Implications for the Thermal Stability of Phosphopantetheine Adenylyltransferase from Thermus Thermophilus. Acta Crystallogr.,Sect.D, 60, 2004
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1LGY
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![BU of 1lgy by Molmil](/molmil-images/mine/1lgy) | LIPASE II FROM RHIZOPUS NIVEUS | Descriptor: | TRIACYLGLYCEROL LIPASE | Authors: | Kohno, M, Funatsu, J, Mikami, B, Kugimiya, W, Matsuo, T, Morita, Y. | Deposit date: | 1996-05-23 | Release date: | 1996-12-23 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of lipase II from Rhizopus niveus at 2.2 A resolution. J.Biochem.(Tokyo), 120, 1996
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6LJD
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![BU of 6ljd by Molmil](/molmil-images/mine/6ljd) | Crystal structure of fragmin F2-F3 domains (calcium condition) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Actin-binding protein fragmin P, CALCIUM ION, ... | Authors: | Takeda, S. | Deposit date: | 2019-12-14 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Novel inter-domain Ca2+-binding site in the gelsolin superfamily protein fragmin. J.Muscle Res.Cell.Motil., 41, 2020
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6KWZ
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![BU of 6kwz by Molmil](/molmil-images/mine/6kwz) | Crystal structure of fragmin F3 domain with calcium ion | Descriptor: | Actin-binding protein fragmin P, CALCIUM ION | Authors: | Takeda, S. | Deposit date: | 2019-09-09 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Novel inter-domain Ca2+-binding site in the gelsolin superfamily protein fragmin. J.Muscle Res.Cell.Motil., 41, 2020
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6LJF
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1UA7
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![BU of 1ua7 by Molmil](/molmil-images/mine/1ua7) | Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose | Descriptor: | 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-alpha-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha-amylase, ... | Authors: | Kagawa, M, Fujimoto, Z, Momma, M, Takase, K, Mizuno, H. | Deposit date: | 2003-03-03 | Release date: | 2004-05-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose J.BACTERIOL., 185, 2003
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5YFI
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![BU of 5yfi by Molmil](/molmil-images/mine/5yfi) | Crystal structure of the anti-human prostaglandin E receptor EP4 antibody Fab fragment | Descriptor: | Heavy chain of Fab fragment, Light chain of Fab fragment, ZINC ION | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-09-21 | Release date: | 2018-12-05 | Last modified: | 2019-03-06 | Method: | X-RAY DIFFRACTION (1.848 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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5YHL
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![BU of 5yhl by Molmil](/molmil-images/mine/5yhl) | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative | Descriptor: | 4-[2-[[(2R)-2-(4-bromanylnaphthalen-1-yl)propanoyl]amino]-4-cyano-phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ... | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-09-28 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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5YWY
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![BU of 5ywy by Molmil](/molmil-images/mine/5ywy) | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208 | Descriptor: | 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ... | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-11-30 | Release date: | 2018-12-05 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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1A7V
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![BU of 1a7v by Molmil](/molmil-images/mine/1a7v) | CYTOCHROME C' FROM RHODOPSEUDOMONAS PALUSTRIS | Descriptor: | CYTOCHROME C', PROTOPORPHYRIN IX CONTAINING FE | Authors: | Shibata, N, Iba, S, Misaki, S, Meyer, T.E, Bartsch, R.G, Cusanovich, M.A, Higuchi, Y, Yasuoka, N. | Deposit date: | 1998-03-18 | Release date: | 1998-06-17 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Basis for monomer stabilization in Rhodopseudomonas palustris cytochrome c' derived from the crystal structure. J.Mol.Biol., 284, 1998
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5TMK
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![BU of 5tmk by Molmil](/molmil-images/mine/5tmk) | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor | Descriptor: | 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-5-phenyl-1H-pyrrole-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.C, Lane, W. | Deposit date: | 2016-10-13 | Release date: | 2017-10-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor To be published
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5TMG
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![BU of 5tmg by Molmil](/molmil-images/mine/5tmg) | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.C, Lane, W. | Deposit date: | 2016-10-12 | Release date: | 2017-10-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor To be published
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4DWW
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![BU of 4dww by Molmil](/molmil-images/mine/4dww) | |
4GY9
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![BU of 4gy9 by Molmil](/molmil-images/mine/4gy9) | Crystal Structure of Medicago truncatula Nodulin 13 (MtN13) in complex with N6-isopentenyladenine (2iP) | Descriptor: | MALONATE ION, MtN13 protein, N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE, ... | Authors: | Ruszkowski, M, Sikorski, M, Jaskolski, M. | Deposit date: | 2012-09-05 | Release date: | 2013-09-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | The landscape of cytokinin binding by a plant nodulin. Acta Crystallogr.,Sect.D, 69, 2013
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4JHI
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![BU of 4jhi by Molmil](/molmil-images/mine/4jhi) | Crystal Structure of Medicago truncatula Nodulin 13 (MtN13) in complex with N6-benzyladenine | Descriptor: | MtN13 protein, N-BENZYL-9H-PURIN-6-AMINE, SODIUM ION | Authors: | Ruszkowski, M, Sikorski, M, Jaskolski, M. | Deposit date: | 2013-03-05 | Release date: | 2013-12-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The landscape of cytokinin binding by a plant nodulin. Acta Crystallogr.,Sect.D, 69, 2013
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4PSB
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4Q0K
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![BU of 4q0k by Molmil](/molmil-images/mine/4q0k) | Crystal Structure of Phytohormone Binding Protein from Medicago truncatula in complex with gibberellic acid (GA3) | Descriptor: | GIBBERELLIN A3, GLYCEROL, PHYTOHORMONE BINDING PROTEIN MTPHBP | Authors: | Ciesielska, A, Barciszewski, J, Ruszkowski, M, Jaskolski, M, Sikorski, M. | Deposit date: | 2014-04-02 | Release date: | 2014-04-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold. Acta Crystallogr.,Sect.D, 70, 2014
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4JHG
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![BU of 4jhg by Molmil](/molmil-images/mine/4jhg) | Crystal Structure of Medicago truncatula Nodulin 13 (MtN13) in complex with trans-zeatin | Descriptor: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, MALONATE ION, MtN13 protein, ... | Authors: | Ruszkowski, M, Tusnio, K, Ciesielska, A, Brzezinski, K, Dauter, M, Dauter, Z, Sikorski, M, Jaskolski, M. | Deposit date: | 2013-03-05 | Release date: | 2013-03-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The landscape of cytokinin binding by a plant nodulin. Acta Crystallogr.,Sect.D, 69, 2013
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4JHH
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![BU of 4jhh by Molmil](/molmil-images/mine/4jhh) | Crystal Structure of Medicago truncatula Nodulin 13 (MtN13) in complex with kinetin | Descriptor: | MALONATE ION, MtN13 protein, N-(FURAN-2-YLMETHYL)-7H-PURIN-6-AMINE, ... | Authors: | Ruszkowski, M, Sikorski, M, Jaskolski, M. | Deposit date: | 2013-03-05 | Release date: | 2013-12-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The landscape of cytokinin binding by a plant nodulin. Acta Crystallogr.,Sect.D, 69, 2013
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8IG0
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![BU of 8ig0 by Molmil](/molmil-images/mine/8ig0) | Crystal structure of menin in complex with DS-1594b | Descriptor: | (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol, DIMETHYL SULFOXIDE, Menin, ... | Authors: | Suzuki, M, Yoneyama, T, Imai, E. | Deposit date: | 2023-02-20 | Release date: | 2023-03-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1. Cancer Cell Int, 23, 2023
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