5KOT

Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor

Summary for 5KOT

• Entry DOI: 10.2210/pdb5kot/pdb
• Related: 5KOQ 5KOS
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide, ... (7 entities in total)
• Functional Keywords: protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 77139.58

Authors

Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.-C.,Lane, W. (deposition date: 2016-07-01, release date: 2017-07-05, Last modification date: 2020-07-29)

• Primary citation: Imaeda, Y.,Tokuhara, H.,Fukase, Y.,Kanagawa, R.,Kajimoto, Y.,Kusumoto, K.,Kondo, M.,Snell, G.P.,Behnke, C.A.,Kuroita, T.; Discovery of TAK-272: A Novel, Potent and Orally Active Renin Inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)