5KOT
Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Renin | polymer | 337 | 36939.6 | 2 | UniProt (P00797) Pfam (PF00026) | Homo sapiens (Human) | Angiotensinogenase |
| 2 | C, Q (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, R (A, B) | 1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide | non-polymer | 499.6 | 2 | Chemie (6VU) | |||
| 4 | E, S (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | F, G, H, T (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | I, J, K, L, M... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 14 | Chemie (DMS) | |||
| 7 | AA, BA (A, B) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73879.2 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3260.4 | |
| All* | Total formula weight | 77139.6 |
