5TMG

Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor

Summary for 5TMG

• Entry DOI: 10.2210/pdb5tmg/pdb
• Related: 5TMK
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide, ... (7 entities in total)
• Functional Keywords: protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 76015.81

Authors

Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.C.,Lane, W. (deposition date: 2016-10-12, release date: 2017-10-18, Last modification date: 2020-07-29)

• Primary citation: Tokuhara, H.,Imaeda, Y.,Fukase, Y.,Iwanaga, K.,Taya, N.,Watanabe, K.,Kanagawa, R.,Matsuda, K.,Kajimoto, Y.,Kusumoto, K.,Kondo, M.,Snell, G.P.,Behnke, C.A.,Kuroita, T.; Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)