5TMG
Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor
Summary for 5TMG
Entry DOI | 10.2210/pdb5tmg/pdb |
Related | 5TMK |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide, ... (7 entities in total) |
Functional Keywords | protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76015.81 |
Authors | Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.C.,Lane, W. (deposition date: 2016-10-12, release date: 2017-10-18, Last modification date: 2020-07-29) |
Primary citation | Tokuhara, H.,Imaeda, Y.,Fukase, Y.,Iwanaga, K.,Taya, N.,Watanabe, K.,Kanagawa, R.,Matsuda, K.,Kajimoto, Y.,Kusumoto, K.,Kondo, M.,Snell, G.P.,Behnke, C.A.,Kuroita, T. Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor To be published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report