4E0O
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![BU of 4e0o by Molmil](/molmil-images/mine/4e0o) | SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form III) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | Authors: | Zhao, M, Liu, C, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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4E0N
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![BU of 4e0n by Molmil](/molmil-images/mine/4e0n) | SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | Authors: | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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3DGJ
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![BU of 3dgj by Molmil](/molmil-images/mine/3dgj) | NNFGAIL segment from Islet Amyloid Polypeptide (IAPP or amylin) | Descriptor: | NNFGAIL peptide | Authors: | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2008-06-13 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci., 17, 2008
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1LNX
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![BU of 1lnx by Molmil](/molmil-images/mine/1lnx) | Crystal structure of the P.aerophilum SmAP1 heptamer in a new crystal form (C2221) | Descriptor: | ACETIC ACID, GLYCEROL, URIDINE, ... | Authors: | Mura, C, Kozhukhovsky, A, Eisenberg, D. | Deposit date: | 2002-05-04 | Release date: | 2003-03-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs) Protein Sci., 12, 2003
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1Z6K
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![BU of 1z6k by Molmil](/molmil-images/mine/1z6k) | Citrate lyase beta subunit complexed with oxaloacetate and magnesium from M. tuberculosis | Descriptor: | Citrate Lyase beta subunit, MAGNESIUM ION, OXALOACETATE ION | Authors: | Goulding, C.W, Bowers, P.M, Segelke, B, Lekin, T, Kim, C.Y, Terwilliger, T.C, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-03-22 | Release date: | 2005-05-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function. J.Mol.Biol., 365, 2007
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3DG1
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![BU of 3dg1 by Molmil](/molmil-images/mine/3dg1) | Segment SSTNVG derived from IAPP | Descriptor: | SSTNVG from Islet Amyloid Polypeptide | Authors: | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2008-06-12 | Release date: | 2008-07-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci., 17, 2008
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1LOJ
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![BU of 1loj by Molmil](/molmil-images/mine/1loj) | Crystal structure of a Methanobacterial Sm-like archaeal protein (SmAP1) bound to uridine-5'-monophosphate (UMP) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, URIDINE, URIDINE-5'-MONOPHOSPHATE, ... | Authors: | Mura, C, Kozhukhovsky, A, Eisenberg, D. | Deposit date: | 2002-05-06 | Release date: | 2003-03-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs) Protein Sci., 12, 2003
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1MDT
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1BP1
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![BU of 1bp1 by Molmil](/molmil-images/mine/1bp1) | CRYSTAL STRUCTURE OF BPI, THE HUMAN BACTERICIDAL PERMEABILITY-INCREASING PROTEIN | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN | Authors: | Beamer, L.J, Carroll, S.F, Eisenberg, D. | Deposit date: | 1997-04-08 | Release date: | 1997-09-04 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science, 276, 1997
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1AZV
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![BU of 1azv by Molmil](/molmil-images/mine/1azv) | FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN) | Descriptor: | COPPER (II) ION, COPPER/ZINC SUPEROXIDE DISMUTASE, ZINC ION | Authors: | Hart, P.J, Liu, H, Pellegrini, M, Nersissian, A.M, Gralla, E.B, Valentine, J.S, Eisenberg, D. | Deposit date: | 1997-11-21 | Release date: | 1998-02-25 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis. Protein Sci., 7, 1998
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3DBO
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![BU of 3dbo by Molmil](/molmil-images/mine/3dbo) | Crystal structure of a member of the VapBC family of toxin-antitoxin systems, VapBC-5, from Mycobacterium tuberculosis | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, SODIUM ION, ... | Authors: | Miallau, L, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2008-06-02 | Release date: | 2008-07-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 FROM MYCOBACTERIUM TUBERCULOSIS. J.Biol.Chem., 284, 2009
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3H87
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![BU of 3h87 by Molmil](/molmil-images/mine/3h87) | Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, IMIDAZOLE, ... | Authors: | Min, A, Sawaya, M.R, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI) | Deposit date: | 2009-04-28 | Release date: | 2009-05-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site. Protein Sci., 21, 2012
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3H6P
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![BU of 3h6p by Molmil](/molmil-images/mine/3h6p) | Crystal structure of Rv3019c-Rv3020c from Mycobacterium tuberculosis | Descriptor: | ESAT-6 LIKE PROTEIN ESXS, ESAT-6-like protein esxR, GLYCEROL | Authors: | Chan, S, Arbing, M, Phan, T, Kaufmann, M, Cascio, D, Eisenberg, D, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI) | Deposit date: | 2009-04-23 | Release date: | 2009-06-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of Rv3019c-Rv3020c from Mycobacterium tuberculosis To be Published
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1P7G
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![BU of 1p7g by Molmil](/molmil-images/mine/1p7g) | Crystal structure of superoxide dismutase from Pyrobaculum aerophilum | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, Superoxide dismutase | Authors: | Lee, S, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2003-05-01 | Release date: | 2003-12-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of superoxide dismutase from Pyrobaculum aerophilum presents a challenging case in molecular replacement with multiple molecules, pseudo-symmetry and twinning. Acta Crystallogr.,Sect.D, 59, 2003
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1YJO
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![BU of 1yjo by Molmil](/molmil-images/mine/1yjo) | Structure of NNQQNY from yeast prion Sup35 with zinc acetate | Descriptor: | ACETIC ACID, Eukaryotic peptide chain release factor GTP-binding subunit, ZINC ION | Authors: | Nelson, R, Sawaya, M.R, Balbirnie, M, Madsen, A.O, Riekel, C, Grothe, R, Eisenberg, D. | Deposit date: | 2005-01-15 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure of the cross-beta spine of amyloid-like fibrils. Nature, 435, 2005
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1YJP
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![BU of 1yjp by Molmil](/molmil-images/mine/1yjp) | Structure of GNNQQNY from yeast prion Sup35 | Descriptor: | Eukaryotic peptide chain release factor GTP-binding subunit | Authors: | Nelson, R, Sawaya, M.R, Balbirnie, M, Madsen, A.O, Riekel, C, Grothe, R, Eisenberg, D. | Deposit date: | 2005-01-15 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the cross-beta spine of amyloid-like fibrils. Nature, 435, 2005
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1YKW
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![BU of 1ykw by Molmil](/molmil-images/mine/1ykw) | |
1N2B
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![BU of 1n2b by Molmil](/molmil-images/mine/1n2b) | Crystal Structure of a Pantothenate Synthetase from M. tuberculosis in complex with AMPCPP and pantoate, higher occupancy of pantoate and lower occupancy of AMPCPP in subunit A | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ETHANOL, GLYCEROL, ... | Authors: | Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-10-22 | Release date: | 2003-04-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of a pantothenate
synthetase from M. tuberculosis and its
complexes with substrates and a
reaction intermediate Protein Sci., 12, 2003
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1N2O
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1NBU
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![BU of 1nbu by Molmil](/molmil-images/mine/1nbu) | 7,8-Dihydroneopterin Aldolase Complexed with Product From Mycobacterium Tuberculosis | Descriptor: | 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, Probable dihydroneopterin aldolase | Authors: | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Phillips, M, Parseghian, A, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-03 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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1PG1
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![BU of 1pg1 by Molmil](/molmil-images/mine/1pg1) | PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES | Descriptor: | PROTEGRIN-1 | Authors: | Fahrner, R.L, Dieckmann, T, Harwig, S.S.L, Lehrer, R.I, Eisenberg, D, Feigon, J. | Deposit date: | 1998-03-20 | Release date: | 1998-05-27 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. Chem.Biol., 3, 1996
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1Z9W
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![BU of 1z9w by Molmil](/molmil-images/mine/1z9w) | Tetrameric structure of apo-7,8-Dihydroneopterin Aldolase from Mycobacterium tuberculosis | Descriptor: | Dihydroneopterin aldolase | Authors: | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Philips, M, Parseghian, A, Eisenberg, D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2005-04-05 | Release date: | 2005-04-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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1N2G
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![BU of 1n2g by Molmil](/molmil-images/mine/1n2g) | |
1N2E
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![BU of 1n2e by Molmil](/molmil-images/mine/1n2e) | |
1N2J
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![BU of 1n2j by Molmil](/molmil-images/mine/1n2j) | |