5J8F
 
 | | Human MOF K274P crystal structure | | Descriptor: | CHLORIDE ION, Histone acetyltransferase KAT8, ZINC ION | | Authors: | McCullough, C.E, Marmorstein, R. | | Deposit date: | 2016-04-07 | | Release date: | 2016-07-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation.
J.Biol.Chem., 291, 2016
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5JRQ
 | | BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM | | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide, ... | | Authors: | Grasso, M.J, Marmorstein, R. | | Deposit date: | 2016-05-06 | | Release date: | 2016-09-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.287 Å) | | Cite: | Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
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5JSM
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5JT2
 | | BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE | | Descriptor: | 2,2'-oxybis(N-{[4-(3-{2,6-difluoro-3-[(propane-1-sulfonyl)amino]benzoyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methyl}acetamide), BENZAMIDINE, Serine/threonine-protein kinase B-raf | | Authors: | Grasso, M.J, Marmorstein, R. | | Deposit date: | 2016-05-09 | | Release date: | 2016-09-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.702 Å) | | Cite: | Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
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6UI9
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6UV5
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6UUW
 | | Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA | | Descriptor: | (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2019-11-01 | | Release date: | 2019-12-25 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Molecular basis for acetyl-CoA production by ATP-citrate lyase
Nat.Struct.Mol.Biol., 27, 2020
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2FQ3
 | | Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes | | Descriptor: | Transcription regulatory protein SWI3 | | Authors: | Da, G, Lenkart, J, Zhao, K, Shiekhattar, R, Cairns, B.R, Marmorstein, R. | | Deposit date: | 2006-01-17 | | Release date: | 2006-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes
Proc.Natl.Acad.Sci.Usa, 103, 2006
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7RB3
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7RMP
 | | Structure of ACLY D1026A - substrates-asym | | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-07-28 | | Release date: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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7RIG
 | | Structure of ACLY-D1026A-substrates | | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-07-19 | | Release date: | 2023-05-10 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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7RKZ
 | | Structure of ACLY D1026A-substrates-asym-int | | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-07-22 | | Release date: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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7SNI
 | | Structure of G6PD-D200N tetramer bound to NADP+ and G6P | | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-10-28 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNH
 | | Structure of G6PD-D200N tetramer bound to NADP+ | | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-10-28 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNG
 | | structure of G6PD-WT tetramer | | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-10-28 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNF
 | | Structure of G6PD-WT dimer | | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-10-28 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7STX
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2QIY
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1ZX2
 | | Crystal Structure of Yeast UBP3-associated Protein BRE5 | | Descriptor: | UBP3-associated protein BRE5 | | Authors: | Li, K, Zhao, K, Ossareh-Nazari, B, Da, G, Dargemont, C, Marmorstein, R. | | Deposit date: | 2005-06-06 | | Release date: | 2005-06-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
J.Biol.Chem., 280, 2005
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7L1K
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1QP9
 | | STRUCTURE OF HAP1-PC7 COMPLEXED TO THE UAS OF CYC7 | | Descriptor: | CYP1(HAP1-PC7) ACTIVATORY PROTEIN, DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3'), ... | | Authors: | Lukens, A, King, D, Marmorstein, R. | | Deposit date: | 1999-06-01 | | Release date: | 2000-10-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation.
Nucleic Acids Res., 28, 2000
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1IHB
 | | CRYSTAL STRUCTURE OF P18-INK4C(INK6) | | Descriptor: | CYCLIN-DEPENDENT KINASE 6 INHIBITOR | | Authors: | Ravichandran, V, Swaminathan, K, Marmorstein, R. | | Deposit date: | 1997-10-25 | | Release date: | 1998-12-02 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations.
Nat.Struct.Biol., 5, 1998
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4GS4
 | | Structure of the alpha-tubulin acetyltransferase, alpha-TAT1 | | Descriptor: | ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase | | Authors: | Friedmann, D.R, Fan, J, Marmorstein, R. | | Deposit date: | 2012-08-27 | | Release date: | 2012-10-17 | | Last modified: | 2013-08-28 | | Method: | X-RAY DIFFRACTION (2.112 Å) | | Cite: | Structure of the alpha-tubulin acetyltransferase, alpha TAT1, and implications for tubulin-specific acetylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4K2J
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3TFY
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