5JT2

BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE

Summary for 5JT2

Entry DOI	10.2210/pdb5jt2/pdb
Related	5JRQ 5JSM
Descriptor	Serine/threonine-protein kinase B-raf, BENZAMIDINE, 2,2'-oxybis(N-{[4-(3-{2,6-difluoro-3-[(propane-1-sulfonyl)amino]benzoyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methyl}acetamide), ... (4 entities in total)
Functional Keywords	kinase, dimer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	129892.45
Authors	Grasso, M.J.,Marmorstein, R. (deposition date: 2016-05-09, release date: 2016-09-14, Last modification date: 2023-10-18)
Primary citation	Grasso, M.,Estrada, M.A.,Ventocilla, C.,Samanta, M.,Maksimoska, J.,Villanueva, J.,Winkler, J.D.,Marmorstein, R. Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. Acs Chem.Biol., 11:2876-2888, 2016 Cited by PubMed: 27571413 DOI: 10.1021/acschembio.6b00529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.702 Å)

Structure validation