5JSM
BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-3-VEM
Summary for 5JSM
| Entry DOI | 10.2210/pdb5jsm/pdb |
| Related | 5JRQ 5JT2 |
| Descriptor | Serine/threonine-protein kinase B-raf, DIMETHYL SULFOXIDE, BENZAMIDINE, ... (8 entities in total) |
| Functional Keywords | kinase, dimer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 130677.91 |
| Authors | Grasso, M.J.,Marmorstein, R. (deposition date: 2016-05-08, release date: 2016-09-14, Last modification date: 2023-09-27) |
| Primary citation | Grasso, M.,Estrada, M.A.,Ventocilla, C.,Samanta, M.,Maksimoska, J.,Villanueva, J.,Winkler, J.D.,Marmorstein, R. Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. Acs Chem.Biol., 11:2876-2888, 2016 Cited by PubMed: 27571413DOI: 10.1021/acschembio.6b00529 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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