4A50
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![BU of 4a50 by Molmil](/molmil-images/mine/4a50) | Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid | Descriptor: | (2R)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, (2S)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Kaan, H.Y.K, Kozielski, F. | Deposit date: | 2011-10-24 | Release date: | 2012-10-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity. J.Med.Chem., 55, 2012
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4BBG
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![BU of 4bbg by Molmil](/molmil-images/mine/4bbg) | |
2X7C
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![BU of 2x7c by Molmil](/molmil-images/mine/2x7c) | Crystal structure of human kinesin Eg5 in complex with (S)-enastron | Descriptor: | (S)-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4,7,8-HEXAHYDROQUINAZOLIN-5(6H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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2WOG
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![BU of 2wog by Molmil](/molmil-images/mine/2wog) | Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Hackney, D.D, Kozielski, F. | Deposit date: | 2009-07-23 | Release date: | 2010-08-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex. Biochem.J., 425, 2010
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2Y5W
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![BU of 2y5w by Molmil](/molmil-images/mine/2y5w) | |
2Y65
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![BU of 2y65 by Molmil](/molmil-images/mine/2y65) | |
2XT3
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![BU of 2xt3 by Molmil](/molmil-images/mine/2xt3) | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | Authors: | Klejnot, M, Kozielski, F. | Deposit date: | 2010-10-04 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.882 Å) | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling. Acta Crystallogr.,Sect.D, 68, 2012
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2X7D
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![BU of 2x7d by Molmil](/molmil-images/mine/2x7d) | Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron | Descriptor: | (4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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2X7E
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![BU of 2x7e by Molmil](/molmil-images/mine/2x7e) | Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol | Descriptor: | (4R)-5-[(S)-(3,4-DIFLUOROPHENYL)(HYDROXY)METHYL]-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-3,4-DIHYDROPYRIMIDINE-2(1H)-THIONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F. | Deposit date: | 2010-02-26 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol. J.Med.Chem., 53, 2010
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4BEX
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![BU of 4bex by Molmil](/molmil-images/mine/4bex) | Structure of human Cofilin1 | Descriptor: | COFILIN-1 | Authors: | Klejnot, M, Gabrielsen, M, Cameron, J, Mleczak, A, Talapatra, S.K, Kozielski, F, Pannifer, A, Olson, M.F. | Deposit date: | 2013-03-12 | Release date: | 2013-08-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Analysis of the Human Cofilin1 Structure Reveals Conformational Changes Required for Actin-Binding Acta Crystallogr.,Sect.D, 69, 2013
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4AS7
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![BU of 4as7 by Molmil](/molmil-images/mine/4as7) | Eg5 complex 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2012-04-29 | Release date: | 2013-05-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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4A1Z
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![BU of 4a1z by Molmil](/molmil-images/mine/4a1z) | Eg5-1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2011-09-20 | Release date: | 2012-10-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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4AP0
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![BU of 4ap0 by Molmil](/molmil-images/mine/4ap0) | The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ... | Authors: | Schuettelkopf, A.W, Talapatra, S.K, Kozielski, F. | Deposit date: | 2012-03-30 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.594 Å) | Cite: | The Structure of the Ternary Eg5-Adp-Ispinesib Complex Acta Crystallogr.,Sect.D, 68, 2012
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4B7B
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![BU of 4b7b by Molmil](/molmil-images/mine/4b7b) | Eg5-3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CALCIUM ION, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2012-08-17 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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4A28
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![BU of 4a28 by Molmil](/molmil-images/mine/4a28) | Eg5-2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2011-09-22 | Release date: | 2012-10-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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4A14
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![BU of 4a14 by Molmil](/molmil-images/mine/4a14) | HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION | Authors: | Klejnot, M, Kozielski, F. | Deposit date: | 2011-09-14 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling. Acta Crystallogr.,Sect.D, 68, 2012
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4A5Y
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![BU of 4a5y by Molmil](/molmil-images/mine/4a5y) | |
3ZCW
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![BU of 3zcw by Molmil](/molmil-images/mine/3zcw) | Eg5 - New allosteric binding site | Descriptor: | (2E)-2-(3-fluoranyl-4-methoxy-phenyl)imino-1-[[2-(trifluoromethyl)phenyl]methyl]-3H-benzimidazole-5-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Ulaganathan, V, Talapatra, S.K, Kozielski, F, Pannifer, A.D. | Deposit date: | 2012-11-23 | Release date: | 2013-01-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.691 Å) | Cite: | Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein. J.Am.Chem.Soc., 135, 2013
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4BN2
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![BU of 4bn2 by Molmil](/molmil-images/mine/4bn2) | The crystal structure of kinesin-like protein KIF15 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF15, MAGNESIUM ION | Authors: | Klejnot, M, Falnikar, A, Ulaganathan, V, Cross, R, Baas, P, Kozielski, F. | Deposit date: | 2013-05-13 | Release date: | 2014-01-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.695 Å) | Cite: | The Crystal Structure and Biochemical Characterization of Kif15: A Bifunctional Molecular Motor Involved in Bipolar Spindle Formation and Neuronal Development Acta Crystallogr.,Sect.D, 70, 2014
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4BXN
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![BU of 4bxn by Molmil](/molmil-images/mine/4bxn) | Eg5(WT) complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ... | Authors: | Talapatra, S.K, Anthony, N.G, Mackay, S.P, Kozielski, F. | Deposit date: | 2013-07-15 | Release date: | 2013-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.793 Å) | Cite: | The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
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1CZ7
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![BU of 1cz7 by Molmil](/molmil-images/mine/1cz7) | THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MICROTUBULE MOTOR PROTEIN NCD | Authors: | Kozielski, F.K, De Bonis, S, Burmeister, W, Cohen-Addad, C, Wade, R. | Deposit date: | 1999-09-01 | Release date: | 1999-11-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Structure Fold.Des., 7, 1999
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7QUC
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![BU of 7quc by Molmil](/molmil-images/mine/7quc) | D. melanogaster alpha/beta tubulin heterodimer in the GDP form | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUD
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![BU of 7qud by Molmil](/molmil-images/mine/7qud) | D. melanogaster alpha/beta tubulin heterodimer in the GTP form | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1 chain, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUQ
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![BU of 7quq by Molmil](/molmil-images/mine/7quq) | BtubA(R284G,K286D,F287G):BtubB bacterial tubulin M-loop mutant forming a single protofilament (Prosthecobacter dejongeii) | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tubulin beta, Tubulin domain-containing protein | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-18 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUP
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![BU of 7qup by Molmil](/molmil-images/mine/7qup) | D. melanogaster 13-protofilament microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-18 | Release date: | 2022-11-02 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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