7JHH
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![BU of 7jhh by Molmil](/molmil-images/mine/7jhh) | Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Yan, Y, Murkherjee, S, Zhou, X.E, Xu, T.H, Xu, H.E, Kossiakoff, A.A, Melcher, K. | Deposit date: | 2020-07-20 | Release date: | 2021-07-21 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373, 2021
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3HHR
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5CWW
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![BU of 5cww by Molmil](/molmil-images/mine/5cww) | Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex | Descriptor: | Nucleoporin NUP145N, Nucleoporin NUP159, Nucleoporin NUP82 | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-07-28 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
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5CWV
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![BU of 5cwv by Molmil](/molmil-images/mine/5cwv) | Crystal structure of Chaetomium thermophilum Nup192 TAIL domain | Descriptor: | Nucleoporin NUP192 | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-07-28 | Release date: | 2015-09-16 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.155 Å) | Cite: | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
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5CWS
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![BU of 5cws by Molmil](/molmil-images/mine/5cws) | Crystal structure of the intact Chaetomium thermophilum Nsp1-Nup49-Nup57 channel nucleoporin heterotrimer bound to its Nic96 nuclear pore complex attachment site | Descriptor: | Nucleoporin NIC96, Nucleoporin NSP1, Nucleoporin NUP49, ... | Authors: | Bley, C.J, Petrovic, S, Paduch, M, Lu, V, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-07-28 | Release date: | 2015-10-14 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.77 Å) | Cite: | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
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5CWU
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![BU of 5cwu by Molmil](/molmil-images/mine/5cwu) | Crystal structure of Chaetomium thermophilum Nup188 TAIL domain | Descriptor: | GLYCEROL, Nucleoporin NUP188 | Authors: | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-07-28 | Release date: | 2015-09-16 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
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5BJZ
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5BK2
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![BU of 5bk2 by Molmil](/molmil-images/mine/5bk2) | |
5BK1
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5C8J
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![BU of 5c8j by Molmil](/molmil-images/mine/5c8j) | A YidC-like protein in the archaeal plasma membrane | Descriptor: | Antibody fragment, heavy chain, light chain, ... | Authors: | Borowska, M.T, Dominik, P.K, Anghel, S.A, Kossiakoff, A.A, Keenan, R.J. | Deposit date: | 2015-06-25 | Release date: | 2015-09-02 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.502 Å) | Cite: | A YidC-like Protein in the Archaeal Plasma Membrane. Structure, 23, 2015
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5EII
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1TPK
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![BU of 1tpk by Molmil](/molmil-images/mine/1tpk) | CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION | Descriptor: | CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR | Authors: | De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A. | Deposit date: | 1991-09-24 | Release date: | 1992-07-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. Biochemistry, 31, 1992
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8T6I
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![BU of 8t6i by Molmil](/molmil-images/mine/8t6i) | Structure of VHH-Fab complex with engineered Crystal Kappa region | Descriptor: | Fab heavy chain, Fab light chain, GLYCEROL, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-16 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T9Y
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![BU of 8t9y by Molmil](/molmil-images/mine/8t9y) | Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | Descriptor: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-26 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T58
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8T8I
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![BU of 8t8i by Molmil](/molmil-images/mine/8t8i) | Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | Authors: | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | Deposit date: | 2023-06-22 | Release date: | 2023-11-29 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8THE
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![BU of 8the by Molmil](/molmil-images/mine/8the) | Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme | Descriptor: | (2~{R},4~{R},5~{S},6~{S})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{R},4~{R},5~{S},6~{S})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{S})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Heme/hemoglobin uptake outer membrane receptor PhuR, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Knejski, P, Erramilli, S.K, Kossiakoff, A.A. | Deposit date: | 2023-07-15 | Release date: | 2024-01-31 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding. Structure, 32, 2024
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7RTH
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![BU of 7rth by Molmil](/molmil-images/mine/7rth) | Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | Deposit date: | 2021-08-13 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7TBM
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![BU of 7tbm by Molmil](/molmil-images/mine/7tbm) | Composite structure of the dilated human nuclear pore complex (NPC) generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | Descriptor: | DDX19, NUP107 CTD, NUP107 NTD, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-12-22 | Release date: | 2022-06-15 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (37 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7TBL
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![BU of 7tbl by Molmil](/molmil-images/mine/7tbl) | Composite structure of the human nuclear pore complex (NPC) cytoplasmic face generated with a 12A cryo-ET map of the purified HeLa cell NPC | Descriptor: | DDX19, ELYS, GLE1, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-12-22 | Release date: | 2022-06-22 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (23 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7TPG
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![BU of 7tpg by Molmil](/molmil-images/mine/7tpg) | Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its ligand bound state | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, GERANYL DIPHOSPHATE, ... | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | Deposit date: | 2022-01-25 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604, 2022
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7TPJ
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![BU of 7tpj by Molmil](/molmil-images/mine/7tpj) | Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, Putative cell surface polysaccharide polymerase/ligase | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | Deposit date: | 2022-01-25 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604, 2022
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1F6F
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![BU of 1f6f by Molmil](/molmil-images/mine/1f6f) | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | Deposit date: | 2000-06-21 | Release date: | 2000-07-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat.Struct.Biol., 7, 2000
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1FYH
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5E08
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![BU of 5e08 by Molmil](/molmil-images/mine/5e08) | Specific Recognition of a Single-stranded RNA Sequence by an Engineered Synthetic Antibody Fragment | Descriptor: | Fab Heavy Chain, Fab Light Chain, RNA | Authors: | Huang, H, Qin, D, Li, N, Shao, Y, Staley, J.P, Kossiakoff, A.A, Koide, S, Piccirilli, J.A. | Deposit date: | 2015-09-28 | Release date: | 2016-09-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. J.Mol.Biol., 428, 2016
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