4KR1
 
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4DTT
 | | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | | Descriptor: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION | | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | | Deposit date: | 2012-02-21 | | Release date: | 2013-02-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
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4GSC
 | | Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate | | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | | Deposit date: | 2012-08-27 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
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4GS8
 | | Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid | | Descriptor: | Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION | | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | | Deposit date: | 2012-08-27 | | Release date: | 2013-08-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
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8JJ8
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist | | Descriptor: | Beta-2 adrenergic receptor,Soluble cytochrome b562, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-29 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8J7E
 | | Crystal structure of BRIL in complex with 1b3 Fab | | Descriptor: | Antibody 1b3 Fab Heavy chain, Antibody 1b3 Fab Light chain, Soluble cytochrome b562 | | Authors: | Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-04-27 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8JJL
 | | cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist | | Descriptor: | Beta-2 adrenergic receptor,Soluble cytochrome b562, Olodaterol | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-30 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8JJO
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist | | Descriptor: | (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-31 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8TTA
 | | Structure of retromer VPS29-VPS35 (483-796) complexed with Fam21A repeat 21 (1328-1341) | | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | | Deposit date: | 2023-08-13 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (3.46 Å) | | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTC
 | | Structure of retromer VPS29-VPS35 (483-796) complexed with Fam21A repeat 20 (1289-1302) | | Descriptor: | ACETATE ION, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | | Deposit date: | 2023-08-13 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTD
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7CXZ
 | | crystal structure of pco2 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, NICKEL (II) ION, ... | | Authors: | Guo, Q, Xu, C, Liao, S, Chen, Z. | | Deposit date: | 2020-09-02 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.561 Å) | | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana.
J.Struct.Biol., 213, 2021
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7DXJ
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7DXK
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7CHJ
 | | crystal structure of pco4 | | Descriptor: | CITRIC ACID, FE (III) ION, Plant cysteine oxidase 4 | | Authors: | Guo, Q, Xu, C, Liao, S. | | Deposit date: | 2020-07-05 | | Release date: | 2020-11-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana.
J.Struct.Biol., 213, 2021
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7CHI
 | | crystal structure of pco5 | | Descriptor: | FE (III) ION, Plant cysteine oxidase 5 | | Authors: | Guo, Q, Xu, C, Liao, S. | | Deposit date: | 2020-07-05 | | Release date: | 2020-11-25 | | Last modified: | 2021-03-31 | | Method: | X-RAY DIFFRACTION (2.502 Å) | | Cite: | Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana.
J.Struct.Biol., 213, 2021
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3BM4
 | | Crystal Structure of Human ADP-ribose Pyrophosphatase NUDT5 In complex with magnesium and AMPcpr | | Descriptor: | ADP-sugar pyrophosphatase, ALPHA-BETA METHYLENE ADP-RIBOSE, MAGNESIUM ION | | Authors: | Zha, M, Guo, Q, Zhang, Y, Zhong, C, Ou, Y, Ding, J. | | Deposit date: | 2007-12-12 | | Release date: | 2008-05-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular Mechanism of ADP-Ribose Hydrolysis By Human NUDT5 From Structural and Kinetic Studies
J.Mol.Biol., 379, 2008
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1J51
 | | CRYSTAL STRUCTURE OF CYTOCHROME P450CAM MUTANT (F87W/Y96F/V247L/C334A) WITH 1,3,5-TRICHLOROBENZENE | | Descriptor: | 1,3,5-TRICHLORO-BENZENE, CYTOCHROME P450CAM, POTASSIUM ION, ... | | Authors: | Chen, X, Christopher, A, Jones, J, Guo, Q, Xu, F, Cao, R, Wong, L.L, Rao, Z. | | Deposit date: | 2002-01-05 | | Release date: | 2002-01-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene
J.BIOL.CHEM., 277, 2002
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1GH2
 | | Crystal structure of the catalytic domain of a new human thioredoxin-like protein | | Descriptor: | THIOREDOXIN-LIKE PROTEIN | | Authors: | Jin, J, Chen, X, Guo, Q, Yuan, J, Qiang, B, Rao, Z. | | Deposit date: | 2000-11-01 | | Release date: | 2001-05-01 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Crystal structure of the catalytic domain of a human thioredoxin-like protein.
Eur.J.Biochem., 269, 2002
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4CSU
 | | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | | Descriptor: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | | Authors: | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | | Deposit date: | 2014-03-10 | | Release date: | 2014-06-04 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
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2WBY
 | | Crystal structure of human insulin-degrading enzyme in complex with insulin | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ... | | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | | Deposit date: | 2009-03-06 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
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2WC0
 | | crystal structure of human insulin degrading enzyme in complex with iodinated insulin | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | | Deposit date: | 2009-03-06 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
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1XFV
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ... | | Authors: | Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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6XS7
 | | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-D2 | | Descriptor: | 48V-DTY-THR-THR-ILE-TYR-TRP-THR-PRO-LEU-GLY-THR-PHE-PRO-ARG-ILE-ARG, FORMIC ACID, GLYCEROL, ... | | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | | Deposit date: | 2020-07-15 | | Release date: | 2021-07-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
Sci Adv, 7, 2021
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6XSA
 | | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-L2 | | Descriptor: | 48V-TYR-LEU-PRO-THR-ILE-THR-GLY-VAL-GLY-HIS-LEU-TRP-HIS-PRO-LEU, SULFATE ION, Vacuolar protein sorting-associated protein 29 | | Authors: | Chen, K.-E, Guo, Q, Collins, B.M. | | Deposit date: | 2020-07-15 | | Release date: | 2021-07-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
Sci Adv, 7, 2021
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