7NP4
 
 | | cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | Authors: | Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | | Deposit date: | 2021-02-26 | | Release date: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
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7NP3
 | | cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture | | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | Authors: | Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | | Deposit date: | 2021-02-26 | | Release date: | 2021-08-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
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1ZN2
 | | Low Resolution Structure of Response Regulator StyR | | Descriptor: | MAGNESIUM ION, response regulatory protein | | Authors: | Milani, M, Leoni, L, Rampioni, G, Zennaro, E, Ascenzi, P, Bolognesi, M. | | Deposit date: | 2005-05-11 | | Release date: | 2005-09-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism.
STRUCTURE, 13, 2005
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1YIO
 | | Crystallographic structure of response regulator StyR from Pseudomonas fluorescens | | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, response regulatory protein | | Authors: | Milani, M, Leoni, L, Rampioni, G, Zennaro, E, Ascenzi, P, Bolognesi, M. | | Deposit date: | 2005-01-12 | | Release date: | 2005-09-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | An Active-like Structure in the Unphosphorylated StyR Response Regulator Suggests a Phosphorylation- Dependent Allosteric Activation Mechanism
STRUCTURE, 13, 2005
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4RMW
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4RMU
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4RMV
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3OZ1
 | | cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac066 | | Descriptor: | (3S,6S,7R,9aS)-7-[2-(benzylamino)ethyl]-N-(diphenylmethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION | | Authors: | Cossu, F, Malvezzi, F, Mastrangelo, E, Canevari, G, Bolognesi, M, Milani, M. | | Deposit date: | 2010-09-24 | | Release date: | 2010-11-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Recognition of Smac-mimetic compounds by the BIR3 domain of cIAP1
Protein Sci., 2010
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1FLP
 | | STRUCTURE OF THE SULFIDE-REACTIVE HEMOGLOBIN FROM THE CLAM LUCINA PECTINATA: CRYSTALLOGRAPHIC ANALYSIS AT 1.5 ANGSTROMS RESOLUTION | | Descriptor: | HEMOGLOBIN I (AQUO MET), PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Rizzi, M, Wittenberg, J.B, Ascenzi, P, Fasano, M, Coda, A, Bolognesi, M. | | Deposit date: | 1994-05-16 | | Release date: | 1994-07-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the sulfide-reactive hemoglobin from the clam Lucina pectinata. Crystallographic analysis at 1.5 A resolution.
J.Mol.Biol., 244, 1994
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4KL1
 | | HCN4 CNBD in complex with cGMP | | Descriptor: | ACETATE ION, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, ... | | Authors: | Lolicato, M, Arrigoni, C, Zucca, S, Nardini, M, Bucchi, A, Schroeder, I, Simmons, K, Bolognesi, M, DiFrancesco, D, Schwede, F, Fishwick, C.W.G, Johnson, A.P.K, Thiel, G, Moroni, A. | | Deposit date: | 2013-05-07 | | Release date: | 2014-04-30 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat.Chem.Biol., 10, 2014
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3NA4
 | | D53P beta-2 microglobulin mutant | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Beta-2-microglobulin | | Authors: | Azinas, S, Ricagno, S, Bolognesi, M. | | Deposit date: | 2010-06-01 | | Release date: | 2011-06-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | D-strand perturbation and amyloid propensity in beta-2 microglobulin
Febs J., 278, 2011
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2QRW
 | | Crystal structure of Mycobacterium tuberculosis trHbO WG8F mutant | | Descriptor: | CYANIDE ION, Hemoglobin-like protein HbO, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Milani, M, Bolognesi, M. | | Deposit date: | 2007-07-30 | | Release date: | 2007-11-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | The Roles of Tyr(CD1) and Trp(G8) in Mycobacterium tuberculosis Truncated Hemoglobin O in Ligand Binding and on the Heme Distal Site Architecture
Biochemistry, 46, 2007
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6I2Z
 | | Isolated globin domain of the Bordetella pertussis globin-coupled sensor | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Uncharacterized protein | | Authors: | Germani, F, De Schutter, A, Cuypers, B, Berghmans, H, Van Hauwaert, M.-L, Bruno, S, Mozzarelli, A, Moens, L, Van Doorslaer, S, Bolognesi, M, Pesce, A, Dewilde, S. | | Deposit date: | 2018-11-02 | | Release date: | 2019-10-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural and Functional Characterization of the Globin-Coupled Sensors ofAzotobacter vinelandiiandBordetella pertussis.
Antioxid.Redox Signal., 32, 2020
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1RAV
 | | RECOMBINANT AVIDIN | | Descriptor: | AVIDIN | | Authors: | Rosano, C, Arosio, P, Bolognesi, M. | | Deposit date: | 1998-03-27 | | Release date: | 1998-07-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Biochemical characterization and crystal structure of a recombinant hen avidin and its acidic mutant expressed in Escherichia coli.
Eur.J.Biochem., 256, 1998
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4THN
 | | THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUNORM IV | | Authors: | Lombardi, A, De Simone, G, Nastri, F, Galdiero, S, Della Morte, R, Staiano, N, Pedone, C, Bolognesi, M, Pavone, V. | | Deposit date: | 1998-09-18 | | Release date: | 1999-06-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.
Protein Sci., 8, 1999
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4RMR
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4RMQ
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8A11
 | | Cryo-EM structure of the Human SHMT1-RNA complex | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, cytosolic | | Authors: | Spizzichino, S, Marabelli, C, Bharadwaj, A, Jakobi, A.J, Chaves-Sanjuan, A, Giardina, G, Bolognesi, M, Cutruzzola, F. | | Deposit date: | 2022-05-30 | | Release date: | 2023-06-14 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Cryo-EM structure of the Human SHMT1-RNA complex
To Be Published
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4UII
 | | Crystal structure of the Azotobacter vinelandii globin-coupled oxygen sensor in the aquo-met form | | Descriptor: | GGDEF DOMAIN PROTEIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Germani, F, De Schutter, A, Pesce, A, Berghmans, H, Van Hauwaert, M.-L, Cuypers, B, Bruno, S, Mozzarelli, A, Moens, L, Van Doorslaer, S, Bolognesi, M, Nardini, M, Dewilde, S. | | Deposit date: | 2015-03-30 | | Release date: | 2016-04-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.827 Å) | | Cite: | Azotobacter Vinelandii Globin-Coupled Oxygen Sensor is a Diguanylate Cyclase with a Biphasic Oxygen Dissociation
To be Published
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4UIQ
 | | Isolated globin domain of the Bordetella pertussis globin-coupled sensor with a heme at the dimer interface | | Descriptor: | GLOBIN-COUPLED SENSOR WITH DIGUANYLATE CYCLASE ACTIVITY, GLYCEROL, IMIDAZOLE, ... | | Authors: | Germani, F, Donne, J, De Schutter, A, Pesce, A, Berghmans, H, Van Hauwaert, M.-L, Moens, L, Van Doorslaer, S, Bolognesi, M, Nardini, M, Dewilde, S. | | Deposit date: | 2015-03-31 | | Release date: | 2016-04-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Identification of a Putative Allosteric Site in the Sensor Domain of Bordetella Pertussis Globin- Coupled Sensor for the Control of Biofilm Formation
To be Published
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1HKU
 | | CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission | | Descriptor: | C-TERMINAL BINDING PROTEIN 3, FORMIC ACID, GLYCEROL, ... | | Authors: | Nardini, M, Spano, S, Cericola, C, Pesce, A, Massaro, A, Millo, E, Luini, A, Corda, D, Bolognesi, M. | | Deposit date: | 2003-03-11 | | Release date: | 2003-06-19 | | Last modified: | 2016-12-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ctbp/Bars: A Dual-Function Protein Involved in Transcription Co-Repression and Golgi Membrane Fission
Embo J., 22, 2003
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1QHA
 | | HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP | | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Rosano, C, Sabini, E, Deriu, D, Magnani, M, Bolognesi, M. | | Deposit date: | 1999-05-11 | | Release date: | 1999-11-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.
Structure Fold.Des., 7, 1999
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5CKA
 | | Human beta-2 microglobulin double mutant W60G-N83V | | Descriptor: | ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | | Deposit date: | 2015-07-15 | | Release date: | 2016-05-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Sci Rep, 6, 2016
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5CKG
 | | Human beta-2 microglobulin mutant V85E | | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL | | Authors: | Sala, B.M, De Rosa, M, Bolognesi, M, Ricagno, S. | | Deposit date: | 2015-07-15 | | Release date: | 2016-05-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Sci Rep, 6, 2016
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5CFH
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