1MIU
 
 | | Structure of a BRCA2-DSS1 complex | | Descriptor: | Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION | | Authors: | Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P. | | Deposit date: | 2002-08-23 | | Release date: | 2002-09-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA
structure
Science, 297, 2002
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3EI2
 | | Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex | | Descriptor: | 5'-D(*DAP*DAP*DAP*DTP*DGP*DAP*DAP*DTP*(3DR)P*DAP*DAP*DGP*DCP*DAP*DGP*DG)-3', 5'-D(*DCP*DCP*DTP*DGP*DCP*DTP*DTP*DTP*DAP*DTP*DTP*DCP*DAP*DTP*DTP*DT)-3', DNA damage-binding protein 1, ... | | Authors: | Scrima, A, Thoma, N.H. | | Deposit date: | 2008-09-15 | | Release date: | 2009-01-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell(Cambridge,Mass.), 135, 2008
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3EI4
 | | Structure of the hsDDB1-hsDDB2 complex | | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2 | | Authors: | Scrima, A, Pavletich, N.P, Thoma, N.H. | | Deposit date: | 2008-09-15 | | Release date: | 2009-01-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell(Cambridge,Mass.), 135, 2008
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3EI3
 | | Structure of the hsDDB1-drDDB2 complex | | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, TETRAETHYLENE GLYCOL | | Authors: | Scrima, A, Thoma, N.H. | | Deposit date: | 2008-09-15 | | Release date: | 2009-01-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell(Cambridge,Mass.), 135, 2008
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3EI1
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4CHT
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4CI3
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | | Deposit date: | 2013-12-05 | | Release date: | 2014-07-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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4D10
 | | Crystal structure of the COP9 signalosome | | Descriptor: | COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ... | | Authors: | Bunker, R.D, Lingaraju, G.M, Thoma, N.H. | | Deposit date: | 2014-04-30 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
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4D18
 | | Crystal structure of the COP9 signalosome | | Descriptor: | COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ... | | Authors: | Bunker, R.D, Lingaraju, G.M, Thoma, N.H. | | Deposit date: | 2014-05-01 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (4.08 Å) | | Cite: | Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
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4BJT
 | | Crystal structure of the Rap1 C-terminal domain (Rap1-RCT) in complex with the Rap1 binding module of Rif1 (Rif1-RBM) | | Descriptor: | 1,2-ETHANEDIOL, DNA-BINDING PROTEIN RAP1, TELOMERE LENGTH REGULATOR PROTEIN RIF1 | | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | | Deposit date: | 2013-04-19 | | Release date: | 2013-06-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions
Cell(Cambridge,Mass.), 153, 2013
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4BJ5
 | | Crystal structure of Rif2 in complex with the C-terminal domain of Rap1 (Rap1-RCT) | | Descriptor: | DNA-BINDING PROTEIN RAP1, PROTEIN RIF2, SULFATE ION | | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | | Deposit date: | 2013-04-16 | | Release date: | 2013-06-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions
Cell(Cambridge,Mass.), 153, 2013
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4BJ6
 | | Crystal structure Rif2 in complex with the C-terminal domain of Rap1 (Rap1-RCT) | | Descriptor: | DNA-BINDING PROTEIN RAP1, RAP1-INTERACTING FACTOR 2, SULFATE ION | | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | | Deposit date: | 2013-04-16 | | Release date: | 2013-06-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions
Cell(Cambridge,Mass.), 153, 2013
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4BJS
 | | Crystal structure of the Rif1 C-terminal domain (Rif1-CTD) from Saccharomyces cerevisiae | | Descriptor: | TELOMERE LENGTH REGULATOR PROTEIN RIF1 | | Authors: | Bunker, R.D, Shi, T, Gut, H, Scrima, A, Thoma, N.H. | | Deposit date: | 2013-04-19 | | Release date: | 2013-06-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions
Cell(Cambridge,Mass.), 153, 2013
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4D0P
 | | Crystal structure of human CSN4 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COP9 SIGNALOSOME COMPLEX SUBUNIT 4, ... | | Authors: | Bunker, R.D, Lingaraju, G.M, Thoma, N.H. | | Deposit date: | 2014-04-29 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structure of the Cop9 Signalosome
Nature, 512, 2014
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4BJ1
 | | Crystal structure of Saccharomyces cerevisiae RIF2 | | Descriptor: | CHLORIDE ION, PROTEIN RIF2 | | Authors: | Shi, T, Bunker, R.D, Gut, H, Scrima, A, Thoma, N.H. | | Deposit date: | 2013-04-15 | | Release date: | 2013-06-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Rif1 and Rif2 Shape Telomere Funcation and Architecture Through Multivalent RAP1 Interactions
Cell(Cambridge,Mass.), 153, 2013
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4CGY
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4CI1
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | | Deposit date: | 2013-12-05 | | Release date: | 2014-07-16 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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4CI2
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | | Deposit date: | 2013-12-05 | | Release date: | 2014-07-16 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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8AJO
 | | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | | Deposit date: | 2022-07-28 | | Release date: | 2022-11-09 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (30.6 Å) | | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023
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8AJM
 | | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | | Deposit date: | 2022-07-28 | | Release date: | 2022-11-09 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023
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8AJN
 | | Structure of the human DDB1-DCAF12 complex | | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | | Deposit date: | 2022-07-28 | | Release date: | 2022-11-09 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023
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8BU9
 | | Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K | | Descriptor: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | | Authors: | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | Deposit date: | 2022-11-30 | | Release date: | 2023-09-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
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8BUS
 | | Structure of DDB1 bound to DS59-engaged CDK12-cyclin K | | Descriptor: | 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... | | Authors: | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | Deposit date: | 2022-11-30 | | Release date: | 2023-09-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
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8BUF
 | | Structure of DDB1 bound to Z12-engaged CDK12-cyclin K | | Descriptor: | 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... | | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | | Deposit date: | 2022-11-30 | | Release date: | 2023-09-13 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
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8BUA
 | | Structure of DDB1 bound to 919278-engaged CDK12-cyclin K | | Descriptor: | (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... | | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | | Deposit date: | 2022-11-30 | | Release date: | 2023-09-13 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (3.193 Å) | | Cite: | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
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