6I5H
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![BU of 6i5h by Molmil](/molmil-images/mine/6i5h) | Crystal structure of CLK1 in complex with furanopyrimidin VN412 | Descriptor: | 1,2-ETHANEDIOL, 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine, Dual specificity protein kinase CLK1, ... | Authors: | Schroeder, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2018-11-13 | Release date: | 2019-01-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
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5L3L
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![BU of 5l3l by Molmil](/molmil-images/mine/5l3l) | D11 bound IGF-II | Descriptor: | Insulin-like growth factor II | Authors: | Hexnerova, R. | Deposit date: | 2016-05-23 | Release date: | 2016-08-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
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5L3M
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![BU of 5l3m by Molmil](/molmil-images/mine/5l3m) | D11 bound [S39_PQ]-IGF-II | Descriptor: | Insulin-like growth factor II | Authors: | Hexnerova, R. | Deposit date: | 2016-05-23 | Release date: | 2016-08-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
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5L3N
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![BU of 5l3n by Molmil](/molmil-images/mine/5l3n) | D11 bound [N29, S39_PQ]-IGF-II | Descriptor: | Insulin-like growth factor II | Authors: | Hexnerova, R. | Deposit date: | 2016-05-23 | Release date: | 2016-08-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
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6I5L
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![BU of 6i5l by Molmil](/molmil-images/mine/6i5l) | Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound VN316 (derivative of compound 12h) | Descriptor: | 3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine, Dual specificity protein kinase CLK1, GLYCEROL, ... | Authors: | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2018-11-13 | Release date: | 2019-01-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
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6I5I
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![BU of 6i5i by Molmil](/molmil-images/mine/6i5i) | Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound 12h | Descriptor: | 1,2-ETHANEDIOL, 5-(1-methylpyrazol-4-yl)-3-[1-(phenylmethyl)pyrazol-4-yl]furo[3,2-b]pyridine, Dual specificity protein kinase CLK1 | Authors: | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2018-11-13 | Release date: | 2019-01-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
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6I5K
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![BU of 6i5k by Molmil](/molmil-images/mine/6i5k) | Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound VN345 (derivative of compound 12h) | Descriptor: | 5-(1-methylpyrazol-4-yl)-3-(3-propan-2-yloxyphenyl)furo[3,2-b]pyridine, Dual specificity protein kinase CLK1, GLYCEROL, ... | Authors: | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2018-11-13 | Release date: | 2019-01-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
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2N2X
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![BU of 2n2x by Molmil](/molmil-images/mine/2n2x) | |
2N2W
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![BU of 2n2w by Molmil](/molmil-images/mine/2n2w) | |
2MPG
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![BU of 2mpg by Molmil](/molmil-images/mine/2mpg) | Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Kosinova, L, Jiracek, J, Zakova, L, Veverka, V. | Deposit date: | 2014-05-17 | Release date: | 2014-06-11 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. Biochemistry, 53, 2014
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2N2V
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![BU of 2n2v by Molmil](/molmil-images/mine/2n2v) | |
5BOQ
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![BU of 5boq by Molmil](/molmil-images/mine/5boq) | Human insulin with intra-chain chemical crosslink between modified B24 and B29 | Descriptor: | Insulin, SULFATE ION | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | Deposit date: | 2015-05-27 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
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5BPO
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![BU of 5bpo by Molmil](/molmil-images/mine/5bpo) | |
5BQQ
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![BU of 5bqq by Molmil](/molmil-images/mine/5bqq) | Human insulin with intra-chain chemical crosslink between modified B27 and B30 | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | Deposit date: | 2015-05-29 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
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8OW7
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![BU of 8ow7 by Molmil](/molmil-images/mine/8ow7) | Crystal structure of Tannerella forsythia sugar kinase K1058 in complex with N-acetylmuramic acid (MurNAc) | Descriptor: | N-acetyl-beta-muramic acid, N-acetylglucosamine kinase, SULFATE ION | Authors: | Stasiak, A.C, Gogler, K, Fink, P, Stehle, T, Zocher, G. | Deposit date: | 2023-04-27 | Release date: | 2023-08-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia. J.Biol.Chem., 299, 2023
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8OW9
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![BU of 8ow9 by Molmil](/molmil-images/mine/8ow9) | Crystal structure of Tannerella forsythia MurNAc kinase MurK in complex with N-acetylmuramic acid (MurNAc) | Descriptor: | N-acetyl-beta-muramic acid, Putative novel MurNAc kinase | Authors: | Stasiak, A.C, Gogler, K, Fink, P, Stehle, T, Zocher, G. | Deposit date: | 2023-04-27 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia. J.Biol.Chem., 299, 2023
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8OQW
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![BU of 8oqw by Molmil](/molmil-images/mine/8oqw) | Crystal structure of Tannerella forsythia MurNAc kinase MurK | Descriptor: | ATPase, GLYCEROL, SULFATE ION | Authors: | Gogler, K, Fink, P, Stasiak, A.C, Stehle, T, Zocher, G. | Deposit date: | 2023-04-12 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia. J.Biol.Chem., 299, 2023
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8OQX
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![BU of 8oqx by Molmil](/molmil-images/mine/8oqx) | Crystal structure of Tannerella forsythia MurNAc kinase MurK with a phosphate analogue | Descriptor: | 1,2-ETHANEDIOL, ATPase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Gogler, K, Fink, P, Stasiak, A.C, Stehle, T, Zocher, G. | Deposit date: | 2023-04-12 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia. J.Biol.Chem., 299, 2023
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8OQK
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![BU of 8oqk by Molmil](/molmil-images/mine/8oqk) | Crystal structure of Tannerella forsythia sugar kinase K1058 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, N-acetylglucosamine kinase | Authors: | Gogler, K, Fink, P, Stasiak, A.C, Stehle, T, Zocher, G. | Deposit date: | 2023-04-12 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia. J.Biol.Chem., 299, 2023
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