6UUQ
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![BU of 6uuq by Molmil](/molmil-images/mine/6uuq) | Structure of Calcineurin bound to RCAN1 | Descriptor: | Calcipressin-1, FE (III) ION, PHOSPHATE ION, ... | Authors: | Sheftic, S, Page, R, Peti, W. | Deposit date: | 2019-10-31 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Sci Adv, 6, 2020
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6VRO
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![BU of 6vro by Molmil](/molmil-images/mine/6vro) | The structure of the PP2A B56 subunit AIM1 complex | Descriptor: | Beta/gamma crystallin domain-containing protein 1, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Authors: | Wang, X, Page, R, Peti, W. | Deposit date: | 2020-02-08 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. Elife, 9, 2020
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6ATD
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6ALZ
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![BU of 6alz by Molmil](/molmil-images/mine/6alz) | Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin | Descriptor: | (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2017-08-08 | Release date: | 2017-11-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.208 Å) | Cite: | PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. J. Am. Chem. Soc., 139, 2017
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6BSR
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![BU of 6bsr by Molmil](/molmil-images/mine/6bsr) | Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form. | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Moon, T.M, D'Andrea, E.D, Peti, W, Page, R. | Deposit date: | 2017-12-04 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
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4F0Z
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![BU of 4f0z by Molmil](/molmil-images/mine/4f0z) | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L | Descriptor: | Ankyrin repeat domain-containing protein A238L, CALCIUM ION, Calcineurin subunit B type 1, ... | Authors: | Grigoriu, S, Peti, W, Page, R. | Deposit date: | 2012-05-05 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. Plos Biol., 11, 2013
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4EWI
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![BU of 4ewi by Molmil](/molmil-images/mine/4ewi) | Crystal structure of the NLRP4 Pyrin domain | Descriptor: | CHLORIDE ION, NACHT, LRR and PYD domains-containing protein 4, ... | Authors: | Eibl, C, Hessenberger, M, Puehringer, S, Page, R, Diederichs, K, Peti, W. | Deposit date: | 2012-04-27 | Release date: | 2012-09-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural and Functional Analysis of the NLRP4 Pyrin Domain. Biochemistry, 51, 2012
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2OXL
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![BU of 2oxl by Molmil](/molmil-images/mine/2oxl) | Structure and Function of the E. coli Protein YmgB: a Protein Critical for Biofilm Formation and Acid Resistance | Descriptor: | Hypothetical protein ymgB, octyl beta-D-glucopyranoside | Authors: | Page, R, Peti, W, Woods, T.K, Palermino, J.M, Doshi, O. | Deposit date: | 2007-02-20 | Release date: | 2007-10-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Function of the Escherichia coli Protein YmgB: A Protein Critical for Biofilm Formation and Acid-resistance. J.Mol.Biol., 373, 2007
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2G5M
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![BU of 2g5m by Molmil](/molmil-images/mine/2g5m) | Spinophilin PDZ domain | Descriptor: | Neurabin-2 | Authors: | Kelker, M.S, Peti, W. | Deposit date: | 2006-02-23 | Release date: | 2007-01-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural basis for spinophilin-neurabin receptor interaction. Biochemistry, 46, 2007
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2FN5
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2GLE
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![BU of 2gle by Molmil](/molmil-images/mine/2gle) | |
6OBQ
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![BU of 6obq by Molmil](/molmil-images/mine/6obq) | PP1 H66K in complex with Microcystin LR | Descriptor: | MANGANESE (II) ION, Microcystin LR, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBP
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![BU of 6obp by Molmil](/molmil-images/mine/6obp) | Reconstituted PP1 holoenzyme | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBS
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![BU of 6obs by Molmil](/molmil-images/mine/6obs) | PP1 Y134K | Descriptor: | GLYCEROL, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBR
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![BU of 6obr by Molmil](/molmil-images/mine/6obr) | PP1 Y134A in complex with Microcystin LR | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, Microcystin LR, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBN
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![BU of 6obn by Molmil](/molmil-images/mine/6obn) | The crystal structure of coexpressed SDS22:PP1 complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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6OBU
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![BU of 6obu by Molmil](/molmil-images/mine/6obu) | PP1 Y134K in complex with Microcystin LR | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R. | Deposit date: | 2019-03-21 | Release date: | 2019-09-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc.Natl.Acad.Sci.USA, 116, 2019
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8SO0
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![BU of 8so0 by Molmil](/molmil-images/mine/8so0) | Cryo-EM structure of the PP2A:B55-FAM122A complex | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-04-28 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.79961 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8SW6
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8SW5
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8TWI
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![BU of 8twi by Molmil](/molmil-images/mine/8twi) | Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-21 | Release date: | 2023-11-01 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8TWE
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![BU of 8twe by Molmil](/molmil-images/mine/8twe) | Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body | Descriptor: | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-21 | Release date: | 2023-11-01 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8TTB
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![BU of 8ttb by Molmil](/molmil-images/mine/8ttb) | Cryo-EM structure of the PP2A:B55-ARPP19 complex | Descriptor: | FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-08-13 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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8U5G
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![BU of 8u5g by Molmil](/molmil-images/mine/8u5g) | Crystal structure of the co-expressed SDS22:PP1:I3 complex | Descriptor: | E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2023-09-12 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange. J.Biol.Chem., 300, 2023
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3GN5
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![BU of 3gn5 by Molmil](/molmil-images/mine/3gn5) | Structure of the E. coli protein MqsA (YgiT/b3021) | Descriptor: | GLYCEROL, HTH-type transcriptional regulator MQSA (YGIT/b3021), ZINC ION | Authors: | Brown, B.L, Arruda, J.M, Peti, W, Page, R. | Deposit date: | 2009-03-16 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. Plos Pathog., 5, 2009
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