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3GNY
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BU of 3gny by Molmil
Crystal structure of human alpha-defensin 1 (HNP1)
Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.-Y.
Deposit date:2009-03-18
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
4RXZ
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BU of 4rxz by Molmil
Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
Descriptor: 12-MER PEPTIDE INHIBITOR, Protein Mdm4
Authors:Pazgier, M, Gohain, N, Tolbert, W.D.
Deposit date:2014-12-12
Release date:2015-07-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of how stress-induced MDMX phosphorylation activates p53.
Oncogene, 35, 2016
2NLF
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BU of 2nlf by Molmil
Human beta-defensin-1 (Mutant Leu13Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLD
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BU of 2nld by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLE
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BU of 2nle by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLC
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BU of 2nlc by Molmil
Human beta-defensin-1 (mutant Ser8Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLH
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BU of 2nlh by Molmil
Human beta-defensin-1 (Mutant GLN24ALA)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLP
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BU of 2nlp by Molmil
Human beta-defensin-1 (Mutant Gln24Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLS
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BU of 2nls by Molmil
Human beta-defensin-1 (Mutant Gln24Ala)
Descriptor: Beta-defensin 1
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLB
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BU of 2nlb by Molmil
Human beta-defensin-1 (Mutant Asn4Ala)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLG
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BU of 2nlg by Molmil
Human beta-defensin-1 (Mutant Lys22Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLQ
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BU of 2nlq by Molmil
Human beta-defensin-1 (Mutant Lys31Ala)
Descriptor: Beta-defensin 1, GLYCEROL, GLYCINE, ...
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
7S4S
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BU of 7s4s by Molmil
Crystal Structure of SARS-CoV-2 S receptor-binding domain (RBD) in complex CoV11 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CoV11 heavy chain, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2021-09-09
Release date:2021-09-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.
Front Immunol, 14, 2023
4FZE
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BU of 4fze by Molmil
Crystal structure of N26_i1 Fab, an ADCC mediating anti-HIV-1 antibody.
Descriptor: N26_i1 Fab heavy chain, N26_i1 Fab light chain
Authors:Tolbert, W.D, Wu, X, Pazgier, M.
Deposit date:2012-07-06
Release date:2013-07-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Crystal structure of N26_i1 Fab, an ADCC mediating anti-HIV-1 antibody.
To be Published
5VK1
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BU of 5vk1 by Molmil
Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Descriptor: Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI, Protein Mdm4
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2017-04-20
Release date:2018-04-25
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10, 2019
5VK0
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BU of 5vk0 by Molmil
Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2017-04-20
Release date:2018-04-25
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10, 2019
8TTW
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BU of 8ttw by Molmil
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tolbert, W.D, Pozharski, E, Pazgier, M.
Deposit date:2023-08-15
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
5KJR
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BU of 5kjr by Molmil
Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2016-06-20
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
J.Virol., 90, 2016
8SM2
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BU of 8sm2 by Molmil
Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig-like domain-containing protein, Immunoglobulin subtype domain-containing protein, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2023-04-25
Release date:2024-05-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
To Be Published
1T3M
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BU of 1t3m by Molmil
Structure of the isoaspartyl peptidase with L-asparaginase activity from E. coli
Descriptor: NITRATE ION, Putative L-asparaginase, SODIUM ION
Authors:Prahl, A, Pazgier, M, Hejazi, M, Lockau, W, Lubkowski, J.
Deposit date:2004-04-27
Release date:2004-07-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli.
Acta Crystallogr.,Sect.D, 60, 2004
8GDJ
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BU of 8gdj by Molmil
Crystal Structure of HIV-1 LM/HT CLADE A/E CRF01 GP120 Core in Complex with TFH-II-128
Descriptor: (3S,5R)-N-(4-chloro-3-fluorophenyl)-5-(hydroxymethyl)-1-(4-methylpiperazine-1-carbonyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Nguyen, D.N, Tolbert, W.D, Pazgier, M.
Deposit date:2023-03-06
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal Structure of HIV-1 LM/HT CLADE A/E CRF01 GP120 Core in Complex with TFH-II-128
To Be Published
8GDK
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BU of 8gdk by Molmil
Crystal Structure of HIV-1 LM/HT CLADE A/E CRF01 GP120 Core in Complex with TFH-II-151
Descriptor: (3S,5R)-N-(4-chloro-3-fluorophenyl)-5-(hydroxymethyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Tolbert, W.D, Nguyen, D.N, Pazgier, M.
Deposit date:2023-03-06
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of HIV-1 LM/HT CLADE A/E CRF01 GP120 Core in Complex with TFH-II-151
To Be Published
7URQ
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BU of 7urq by Molmil
Crystal Structure of SARS-CoV-2 S delta variant receptor-binding domain (RBD) in complex CoV11 Fab crystal form 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, COV11 Fab HEAVY CHAIN, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2022-04-22
Release date:2022-05-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.
Front Immunol, 14, 2023
7URS
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BU of 7urs by Molmil
Crystal Structure of SARS-CoV-2 S delta variant receptor-binding domain (RBD) in complex CoV11 Fab crystal form 2
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, COV11 Fab HEAVY CHAIN, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2022-04-22
Release date:2022-05-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.
Front Immunol, 14, 2023
4YC2
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BU of 4yc2 by Molmil
Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 from E. coli in complex with the antibody A32.
Descriptor: The antibody A32 Fab heavy chain., The antibody A32 Fab light chain., The stabilized inner domain of clade A/E HIV-1 gp120 from E. coli
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2015-02-19
Release date:2016-03-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Structure, 24, 2016

224004

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