8WPK
 
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exgenous DNA | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
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8WPE
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 (tag-free A22) with exogenous DNA | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
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8WPP
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA | | Descriptor: | A22R DNA polymerase processivity factor, DNA polymerase, E4R Uracil-DNA glycosylase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
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8WPF
 | | Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with exogenous DNA bearing one abasic site | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, A22R DNA polymerase processivity factor, DNA polymerase, ... | | Authors: | Wang, X, Li, N, Gao, N. | | Deposit date: | 2023-10-10 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
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7BV8
 | | Mature 50S ribosomal subunit from RrmJ knock out E.coli strain | | Descriptor: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | Authors: | Wang, W, Li, W.Q, Ge, X.L, Yan, K.G, Mandava, C.S, Sanyal, S, Gao, N. | | Deposit date: | 2020-04-09 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5H4P
 | | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Ma, C, Wu, S, Li, N, Chen, Y, Yan, K, Li, Z, Zheng, L, Lei, J, Woolford, J.L, Gao, N. | | Deposit date: | 2016-11-01 | | Release date: | 2017-01-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1
Nat. Struct. Mol. Biol., 24, 2017
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5H5U
 | | Mechanistic insights into the alternative translation termination by ArfA and RF2 | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Ma, C, Kurita, D, Li, N, Chen, Y, Himeno, H, Gao, N. | | Deposit date: | 2016-11-09 | | Release date: | 2017-01-25 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanistic insights into the alternative translation termination by ArfA and RF2
Nature, 541, 2017
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4CSU
 | | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | | Descriptor: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | | Authors: | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | | Deposit date: | 2014-03-10 | | Release date: | 2014-06-04 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
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4FN8
 | | Crystal structure of the Mtb enoyl CoA isomerase (Rv0632c)in complex with acetoacetyl CoA | | Descriptor: | ACETOACETYL-COENZYME A, Enoyl-CoA hydratase/isomerase family protein, SULFATE ION | | Authors: | Bruning, J.B, Gao, N, Hernandez, E.D, Li, H, Dang, N, Hung, L.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-06-19 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.831 Å) | | Cite: | Crystal structure and mechanism of the prokaryotic enoyl CoA isomerase (ECI)
To be Published
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4FNB
 | | Crystal structure of the Mtb enoyl CoA isomerase (Rv0632c) in complex with hydroxybutyrl CoA | | Descriptor: | 3-HYDROXYBUTANOYL-COENZYME A, Enoyl-CoA hydratase/isomerase family protein, SULFATE ION | | Authors: | Bruning, J.B, Gao, N, Hernandez, E.D, Li, H, Dang, N, Hung, L.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-06-19 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure and Mechanism of the Prokaryotic Enoyl CoA Isomerase
To be Published
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4FN7
 | | Apo Structure of the Mtb enoyol CoA isomerase (Rv0632c) | | Descriptor: | CHLORIDE ION, Enoyl-CoA hydratase/isomerase family protein | | Authors: | Bruning, J.B, Gao, N, Hernandez, E.D, Li, H, Dang, N, Hung, L.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-06-19 | | Release date: | 2013-05-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | "Crystal Structure and Mechanism of the Prokaryotic Enoyl-CoA Isomerase (ECI)"
To be Published
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4FND
 | | Crystal structure of the Mtb enoyl CoA isomerase in complex with hydroxyhexanoyl CoA | | Descriptor: | (S)-3-Hydroxyhexanoyl-CoA, Enoyl-CoA hydratase/isomerase family protein, SULFATE ION | | Authors: | Bruning, J.B, Gao, N, Hernandez, E.D, Li, H, Dang, N, Hung, L.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2012-06-19 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure and mechanism of the prokaryotic enoyl CoA isomerase
To be Published
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7YKT
 | | Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | | Deposit date: | 2022-07-23 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
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7YKL
 | | Cryo-EM structure of Drg1 hexamer treated with AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | | Deposit date: | 2022-07-22 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
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7YKK
 | | Cryo-EM structure of Drg1 hexamer treated with ADP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | | Deposit date: | 2022-07-22 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
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7YKZ
 | | Cryo-EM structure of Drg1 hexamer in the planar state treated with ADP/AMPPNP/Diazaborine | | Descriptor: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | | Deposit date: | 2022-07-25 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
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3J3W
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a) | | Descriptor: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | Authors: | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | Deposit date: | 2013-04-28 | | Release date: | 2013-06-12 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (10.7 Å) | | Cite: | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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3J3V
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a) | | Descriptor: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | Authors: | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | Deposit date: | 2013-04-28 | | Release date: | 2013-06-12 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (13.3 Å) | | Cite: | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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3PN1
 | | Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo | | Descriptor: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-(butylsulfanyl)adenosine, DNA ligase | | Authors: | Mills, S, Eakin, A, Buurman, E, Newman, J, Gao, N, Huynh, H, Johnson, K, Lahiri, S, Shapiro, A, Walkup, G, Wei, Y, Stokes, S. | | Deposit date: | 2010-11-18 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo.
Antimicrob.Agents Chemother., 55, 2011
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5XF8
 | | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | | Descriptor: | Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | | Authors: | Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K. | | Deposit date: | 2017-04-09 | | Release date: | 2017-05-03 | | Method: | ELECTRON MICROSCOPY (7.1 Å) | | Cite: | Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
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3J8G
 | | Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ... | | Authors: | Zhang, X, Yan, K, Zhang, Y, Li, N, Ma, C, Li, Z, Zhang, Y, Feng, B, Liu, J, Sun, Y, Xu, Y, Lei, J, Gao, N. | | Deposit date: | 2014-10-24 | | Release date: | 2014-11-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
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3JAC
 | | Cryo-EM study of a channel | | Descriptor: | Piezo-type mechanosensitive ion channel component 1 | | Authors: | Ge, J, Li, W, Zhao, Q, Li, N, Xiao, B, Gao, N, Yang, M. | | Deposit date: | 2015-06-05 | | Release date: | 2015-09-23 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Architecture of the mammalian mechanosensitive Piezo1 channel
Nature, 527, 2015
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6IV6
 | | Cryo-EM structure of AcrVA5-acetylated MbCas12a in complex with crRNA | | Descriptor: | RNA (59-MER), nuclease | | Authors: | Dong, L, Li, N, Guan, X, Zhu, Y, Gao, N, Huang, Z. | | Deposit date: | 2018-12-02 | | Release date: | 2019-04-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | An anti-CRISPR protein disables type V Cas12a by acetylation.
Nat. Struct. Mol. Biol., 26, 2019
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3JA8
 | | Cryo-EM structure of the MCM2-7 double hexamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ... | | Authors: | Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N. | | Deposit date: | 2015-05-09 | | Release date: | 2015-08-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
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3J3S
 | | Structural dynamics of the MecA-ClpC complex revealed by cryo-EM | | Descriptor: | Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB | | Authors: | Liu, J, Mei, Z, Li, N, Qi, Y, Xu, Y, Shi, Y, Wang, F, Lei, J, Gao, N. | | Deposit date: | 2013-04-18 | | Release date: | 2013-05-15 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (11 Å) | | Cite: | Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
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