6CDE
 
 | | Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | | Authors: | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | | Deposit date: | 2018-02-08 | | Release date: | 2018-05-16 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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6CUE
 | | Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | Acharya, P, Carragher, B, Potter, C.S, Kwong, P.D. | | Deposit date: | 2018-03-26 | | Release date: | 2018-07-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.
PLoS Pathog., 14, 2018
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6UKJ
 | | Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ... | | Authors: | Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F. | | Deposit date: | 2019-10-05 | | Release date: | 2019-12-04 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature, 576, 2019
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6UPL
 | | Structure of FACT_subnucleosome complex 2 | | Descriptor: | DNA (79-mer), FACT complex subunit SPT16, FACT complex subunit SSRP1, ... | | Authors: | Zhou, K, Tan, Y.Z, Wei, H, Liu, Y, Carragher, B, Potter, C, Luger, K. | | Deposit date: | 2019-10-17 | | Release date: | 2019-12-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.4 Å) | | Cite: | FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
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6UPK
 | | Structure of FACT_subnucleosome complex 1 | | Descriptor: | DNA (79-mer), FACT complex subunit SPT16, FACT complex subunit SSRP1, ... | | Authors: | Zhou, K, Tan, Y.Z, Wei, H, Liu, Y, Carragher, B, Potter, C, Luger, K. | | Deposit date: | 2019-10-17 | | Release date: | 2019-12-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
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6BDF
 | | 2.8 A resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy | | Descriptor: | Proteasome subunit alpha, Proteasome subunit beta | | Authors: | Campbell, M.G, Veesler, D, Cheng, A, Potter, C.S, Carragher, B. | | Deposit date: | 2017-10-23 | | Release date: | 2017-12-27 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | 2.8 angstrom resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy.
Elife, 4, 2015
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6CE9
 | | Insulin Receptor ectodomain in complex with two insulin molecules | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | | Deposit date: | 2018-02-11 | | Release date: | 2018-03-14 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
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6CEB
 | | Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | | Deposit date: | 2018-02-11 | | Release date: | 2018-03-14 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
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6CE7
 | | Insulin Receptor ectodomain in complex with one insulin molecule | | Descriptor: | Insulin A chain, Insulin B chain, Insulin receptor, ... | | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | | Deposit date: | 2018-02-11 | | Release date: | 2018-03-14 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (7.4 Å) | | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
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6OT1
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6OSY
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3J5M
 | | Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs | | Descriptor: | BG505 SOSIP gp120, BG505 SOSIP gp41, PGV04 heavy chain, ... | | Authors: | Lyumkis, D, Julien, J.-P, Wilson, I.A, Ward, A.B. | | Deposit date: | 2013-10-26 | | Release date: | 2013-11-13 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
Science, 342, 2013
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5TKJ
 | | Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 | | Descriptor: | HIV-1 fusion peptide residue 512-519, SULFATE ION, vFP1.01 chimeric mouse antibody heavy chain, ... | | Authors: | Xu, K, Liu, K, Kwong, P.D. | | Deposit date: | 2016-10-06 | | Release date: | 2018-04-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.118 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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5WOB
 | | Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin | | Descriptor: | IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... | | Authors: | McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. | | Deposit date: | 2017-08-01 | | Release date: | 2018-04-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.95 Å) | | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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5TKK
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7RZE
 | | Insulin Degrading Enzyme pO/pC | | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | | Deposit date: | 2021-08-27 | | Release date: | 2022-08-31 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZI
 | | Insulin Degrading Enzyme pC/pC | | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | | Deposit date: | 2021-08-27 | | Release date: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZH
 | | Insulin Degrading Enzyme O/O | | Descriptor: | Cysteine-free Insulin-degrading enzyme | | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | | Deposit date: | 2021-08-27 | | Release date: | 2022-08-31 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZG
 | | Insulin Degrading Enzyme O/pO | | Descriptor: | Cysteine-free Insulin-degrading enzyme | | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | | Deposit date: | 2021-08-27 | | Release date: | 2022-08-31 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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7RZF
 | | Insulin Degrading Enzyme O/pC | | Descriptor: | Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain | | Authors: | Mancl, J.M, Liang, W.G, Tang, W.J. | | Deposit date: | 2021-08-27 | | Release date: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
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6E6B
 | | Crystal structure of the Protocadherin GammaB4 extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Goodman, K.M, Mannepalli, S, Bahna, F, Honig, B, Shapiro, L. | | Deposit date: | 2018-07-24 | | Release date: | 2019-04-10 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.52 Å) | | Cite: | Visualization of clustered protocadherin neuronal self-recognition complexes.
Nature, 569, 2019
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6MQC
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6MPH
 | | Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DF1W-a.01 Light chain, ... | | Authors: | Acharya, P, Xu, K, Kwong, P.D. | | Deposit date: | 2018-10-06 | | Release date: | 2019-07-24 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
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6MQM
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6MQR
 | | Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519) | | Descriptor: | CALCIUM ION, HIV fusion peptide residue 512-519, SULFATE ION, ... | | Authors: | Xu, K, Wang, Y, Kwong, P.D. | | Deposit date: | 2018-10-10 | | Release date: | 2019-07-31 | | Last modified: | 2019-11-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
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