6BI0
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![BU of 6bi0 by Molmil](/molmil-images/mine/6bi0) | Trastuzumab Fab N158A, D185A, K190A (Light Chain) Triple Mutant. | Descriptor: | 1,2-ETHANEDIOL, Trastuzumab anti-HER2 Fab Heavy Chain, Trastuzumab anti-HER2 Fab Light Chain | Authors: | DiDonato, M, Spraggon, G. | Deposit date: | 2017-10-31 | Release date: | 2018-02-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.057 Å) | Cite: | Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. Chembiochem, 19, 2018
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3GYL
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![BU of 3gyl by Molmil](/molmil-images/mine/3gyl) | Structure of Prostasin at 1.3 Angstroms resolution in complex with a Calcium Ion. | Descriptor: | CALCIUM ION, GLYCEROL, Prostasin | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2009-04-03 | Release date: | 2009-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
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3FVF
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![BU of 3fvf by Molmil](/molmil-images/mine/3fvf) | The Crystal Structure of Prostasin Complexed with Camostat at 1.6 Angstroms Resolution | Descriptor: | 1-[4-(hydroxymethyl)phenyl]guanidine, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2009-01-15 | Release date: | 2009-05-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
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3GYM
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![BU of 3gym by Molmil](/molmil-images/mine/3gym) | Structure of Prostasin in Complex with Aprotinin | Descriptor: | Pancreatic trypsin inhibitor, Prostasin | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2009-04-03 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
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3E0N
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![BU of 3e0n by Molmil](/molmil-images/mine/3e0n) | The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor | Descriptor: | DPN-PHE-ARM, GLYCEROL, Prostasin heavy chain, ... | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2008-07-31 | Release date: | 2009-06-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
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3E16
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![BU of 3e16 by Molmil](/molmil-images/mine/3e16) | X-ray structure of human prostasin in complex with Benzoxazole warhead peptidomimic, lysine in P3 | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Prostasin, ... | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2008-08-01 | Release date: | 2008-09-09 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg.Med.Chem.Lett., 18, 2008
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3E0P
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![BU of 3e0p by Molmil](/molmil-images/mine/3e0p) | The X-ray structure of Human Prostasin in complex with a covalent benzoxazole inhibitor | Descriptor: | GLYCEROL, Prostasin, benzyl [(1R)-1-({(2S,4R)-2-({(1S)-5-amino-1-[(S)-1,3-benzoxazol-2-yl(hydroxy)methyl]pentyl}carbamoyl)-4-[(4-methylbenzyl)oxy]pyrrolidin-1-yl}carbonyl)-3-phenylpropyl]carbamate | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2008-07-31 | Release date: | 2008-09-09 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg.Med.Chem.Lett., 18, 2008
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3E1X
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![BU of 3e1x by Molmil](/molmil-images/mine/3e1x) | The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution | Descriptor: | GLYCEROL, Prostasin | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | Deposit date: | 2008-08-04 | Release date: | 2009-05-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci., 18, 2009
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8DK7
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![BU of 8dk7 by Molmil](/molmil-images/mine/8dk7) | |
8D28
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![BU of 8d28 by Molmil](/molmil-images/mine/8d28) | |
8D2A
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![BU of 8d2a by Molmil](/molmil-images/mine/8d2a) | |
8D2B
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![BU of 8d2b by Molmil](/molmil-images/mine/8d2b) | |
8D5L
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![BU of 8d5l by Molmil](/molmil-images/mine/8d5l) | Crystal structure of theophylline aptamer in complex with TAL1 | Descriptor: | 4-amino-8-methylpteridine-2,7(1H,8H)-dione, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Menichelli, E, Spraggon, G. | Deposit date: | 2022-06-05 | Release date: | 2022-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Discovery of small molecules that target a tertiary-structured RNA. Proc.Natl.Acad.Sci.USA, 119, 2022
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8D5O
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![BU of 8d5o by Molmil](/molmil-images/mine/8d5o) | |
8D29
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![BU of 8d29 by Molmil](/molmil-images/mine/8d29) | |