7QEE
| SN243 mutant D415N bound to para-nitrophenyl-Beta-D-glucuronide | Descriptor: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, SN243, SULFATE ION, ... | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | Deposit date: | 2021-12-02 | Release date: | 2022-11-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.374 Å) | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
|
|
7QEF
| Crystal structure of para-nitrophenyl-Beta-D-glucuronide bound to a mutant of SN243 (D415A) | Descriptor: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, ACETATE ION, SN243, ... | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | Deposit date: | 2021-12-02 | Release date: | 2022-10-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
|
|
7QE2
| Crystal structure of D-glucuronic acid bound to SN243 | Descriptor: | ACETATE ION, SN243, SULFATE ION, ... | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | Deposit date: | 2021-12-01 | Release date: | 2022-10-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
|
|
7QE1
| Crystal structure of apo SN243 | Descriptor: | SN243, ZINC ION | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | Deposit date: | 2021-12-01 | Release date: | 2022-10-12 | Last modified: | 2023-03-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
|
|
2MKJ
| Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state | Descriptor: | Cytoplasmic polyadenylation element-binding protein 4 | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | Deposit date: | 2014-02-07 | Release date: | 2014-07-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins Genes Dev., 28, 2014
|
|
2MKK
| Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1, RNA (5'-R(*UP*UP*UP*UP*A)-3') | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | Deposit date: | 2014-02-07 | Release date: | 2014-07-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins Genes Dev., 28, 2014
|
|
2MKI
| Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA | Descriptor: | Cytoplasmic polyadenylation element-binding protein 4, RNA (5'-R(*CP*UP*UP*UP*A)-3') | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | Deposit date: | 2014-02-07 | Release date: | 2014-07-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins Genes Dev., 28, 2014
|
|
2MKH
| Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in free state | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1 | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | Deposit date: | 2014-02-07 | Release date: | 2014-07-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins Genes Dev., 28, 2014
|
|
2MKE
| Solution structure of CPEB1 ZZ domain in the free state | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1, ZINC ION | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | Deposit date: | 2014-02-06 | Release date: | 2014-07-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins Genes Dev., 28, 2014
|
|
2CEK
| Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sanson, B, Colletier, J.P, Nachon, F, Gabellieri, E, Fattorusso, C, Campiani, G, Weik, M. | Deposit date: | 2006-02-08 | Release date: | 2006-04-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor. J. Am. Chem. Soc., 128, 2006
|
|
6HQF
| Structure of Phenylalanine ammonia-lyase from Petroselinum crispum in complex with (R)-APEP | Descriptor: | Phenylalanine ammonia-lyase 1, [(1R)-1-amino-2-phenylethyl]phosphonic acid | Authors: | Bata, Z, Molnar, B, Leveles, I, Poppe, L, Vertessy, G.B. | Deposit date: | 2018-09-24 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes Acs Catalysis, 2021
|
|
6H2O
| APO structure of Phenylalanine ammonia-lyase from Petroselinum crispum | Descriptor: | Phenylalanine ammonia-lyase 1 | Authors: | Molnar, B, Bata, Z, Leveles, I, Poppe, L, Vertessy, G.B. | Deposit date: | 2018-07-14 | Release date: | 2019-07-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes Acs Catalysis, 2021
|
|
6F6T
| |
6DHM
| Bovine glutamate dehydrogenase complexed with zinc | Descriptor: | GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
|
|
6DHN
| Bovine glutamate dehydrogenase complexed with Eu3+ | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
|
|
7P2B
| |
6EGR
| Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement | Descriptor: | DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Revtovich, S.V, Demitri, N, Raboni, S, Nikulin, A.D, Morozova, E.A, Demidkina, T.V, Storici, P, Mozzarelli, A. | Deposit date: | 2017-09-12 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity. Biochim Biophys Acta Proteins Proteom, 1866, 2018
|
|
6MNX
| |
4BFD
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | Descriptor: | BETA-SECRETASE 1, DIMETHYL SULFOXIDE, N-[3-[(1S,3S,6S)-5-azanyl-3-methyl-4-azabicyclo[4.1.0]hept-4-en-3-yl]-4-fluoranyl-phenyl]-5-chloranyl-pyridine-2-carbox amide, ... | Authors: | Banner, D.W, Benz, J, Stihle, M. | Deposit date: | 2013-03-18 | Release date: | 2013-06-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bace1 Inhibitors: A Head Group Scan on a Series of Amides. Bioorg.Med.Chem.Lett., 23, 2013
|
|
4BEK
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | Descriptor: | (4S)-4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, BETA-SECRETASE 1, DIMETHYL SULFOXIDE, ... | Authors: | Banner, D.W, Benz, J, Stihle, M. | Deposit date: | 2013-03-11 | Release date: | 2013-06-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Bace1 Inhibitors: A Head Group Scan on a Series of Amides. Bioorg.Med.Chem.Lett., 23, 2013
|
|
4YBI
| Crystal structure of BACE with amino thiazine inhibitor LY2811376 | Descriptor: | (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL | Authors: | Timm, D.E. | Deposit date: | 2015-02-18 | Release date: | 2015-04-01 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J.Neurosci., 31, 2011
|
|
1G6W
| CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM THE YEAST SACCAROMYCES CEREVISIAE | Descriptor: | URE2 PROTEIN | Authors: | Bousset, L, Belrhali, H, Janin, J, Melki, R, Morera, S. | Deposit date: | 2000-11-08 | Release date: | 2001-02-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae. Structure, 9, 2001
|
|
1G6Y
| CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM YEAST SACCHAROMYCES CEREVISIAE | Descriptor: | URE2 PROTEIN | Authors: | Bousset, L, Belrhali, H, Janin, J, Melki, R, Morera, S. | Deposit date: | 2000-11-08 | Release date: | 2001-02-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae. Structure, 9, 2001
|
|
3GTU
| |