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Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:	Acharya, P, Carragher, B, Potter, C.S, Kwong, P.D.
Deposit date:	2018-03-26
Release date:	2018-07-11
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog., 14, 2018

4R4B

Crystal structure of the anti-hiv-1 antibody 2.2c
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, FAB 2.2C HEAVY CHAIN, FAB 2.2C LIGHT CHAIN, ...
Authors:	McLellan, J.S, Acharya, P, Huang, C.-C, Robinson, J, Kwong, P.D.
Deposit date:	2014-08-19
Release date:	2014-09-10
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.199 Å)
Cite:	Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection. J.Virol., 88, 2014

4R4H

Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 Env gp120
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 2.2c, Heavy chain, ...
Authors:	Mclellan, J, Acharya, P, Huang, C.-C, Kwong, P.D.
Deposit date:	2014-08-19
Release date:	2014-09-17
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (4.28 Å)
Cite:	Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection. J.Virol., 88, 2014

4YFL

Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120
Descriptor:	1B2530 Light chain, 1B2530 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Acharya, P, Zhou, T, Moquin, S, Kwong, P.D.
Deposit date:	2015-02-25
Release date:	2015-06-03
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.387 Å)
Cite:	Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015

6UM5

Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Acharya, P, Henderson, R.C, Saunders, K.O, Haynes, B.F.
Deposit date:	2019-10-09
Release date:	2019-12-18
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science, 366, 2019

4JPW

Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ...
Authors:	Acharya, P, Luongo, T, Zhou, T, Kwong, P.D.
Deposit date:	2013-03-19
Release date:	2013-04-17
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.904 Å)
Cite:	Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell(Cambridge,Mass.), 153, 2013

8CSA

Triple mutant (K417N-E484K-N501Y) SARS-CoV-2 spike protein in the 3-RBD-Down conformation (S-GSAS-D614G-K417N-E484K-N501Y)
Descriptor:	Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2022-05-12
Release date:	2022-07-20
Last modified:	2024-01-31
Method:	ELECTRON MICROSCOPY (3.84 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity Science, 2021

7TF8

SARS-CoV-2 Omicron 3-RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-Omicron)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-01-06
Release date:	2022-02-16
Last modified:	2023-04-12
Method:	ELECTRON MICROSCOPY (3.36 Å)
Cite:	Structural diversity of the SARS-CoV-2 Omicron spike. Mol.Cell, 82, 2022

7TEI

SARS-CoV-2 Omicron 1-RBD up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-Omicron)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-01-05
Release date:	2022-02-16
Last modified:	2023-04-12
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Structural diversity of the SARS-CoV-2 Omicron spike. Mol.Cell, 82, 2022

6XRJ

Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage
Descriptor:	DH717.1 heavy chain Fab fragment, DH717.1 light chain Fab fragment
Authors:	Manne, K, Nicely, N.I, Acharya, P.
Deposit date:	2020-07-13
Release date:	2020-12-30
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7SG4

Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 Heavy chain, DH1047 light chain, ...
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-10-04
Release date:	2021-11-10
Last modified:	2022-02-09
Method:	ELECTRON MICROSCOPY (3.43 Å)
Cite:	A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. Sci Transl Med, 14, 2022

8DY6

Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-08-03
Release date:	2023-04-19
Last modified:	2024-05-22
Method:	ELECTRON MICROSCOPY (4.32 Å)
Cite:	Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe, 32, 2024

8DTO

Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-07-26
Release date:	2023-04-19
Last modified:	2024-05-22
Method:	ELECTRON MICROSCOPY (3.57 Å)
Cite:	Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction. Cell Host Microbe, 32, 2024

8FEJ

Langya Virus Fusion Protein (LayV-F) in Pre-Fusion Conformation
Descriptor:	Fusion Protein
Authors:	May, A.J, Pothula, K.R, Janowska, K, Acharya, P.
Deposit date:	2022-12-06
Release date:	2023-04-19
Last modified:	2024-04-24
Method:	ELECTRON MICROSCOPY (4.64 Å)
Cite:	Structures of Langya Virus Fusion Protein Ectodomain in Pre- and Postfusion Conformation. J.Virol., 97, 2023

8FEL

Langya Virus Fusion Protein (LayV-F) in Post-Fusion Conformation
Descriptor:	Fusion Protein
Authors:	May, A.J, Pothula, K.R, Janowska, K, Acharya, P.
Deposit date:	2022-12-06
Release date:	2023-04-19
Last modified:	2024-04-24
Method:	ELECTRON MICROSCOPY (4.64 Å)
Cite:	Structures of Langya Virus Fusion Protein Ectodomain in Pre- and Postfusion Conformation. J.Virol., 97, 2023

8DKF

Antibody DH1030.1 Fab fragment
Descriptor:	DH1030.1 Heavy chain, DH1030.1 Light chain
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2022-07-05
Release date:	2023-07-12
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	DH1030.1 glycan reactive Ab To Be Published

8DP1

Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1030.1 Fab Heavy chain, ...
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2022-07-14
Release date:	2023-07-19
Method:	ELECTRON MICROSCOPY (3.46 Å)
Cite:	Shared recognition mechanism for HIV-1 envelope-reactive V3 glycan broadly neutralizing B cell lineage maturation in humans and macaques To Be Published

8DOW

Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1030.1 Fab Heavy chain, ...
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2022-07-14
Release date:	2023-07-19
Method:	ELECTRON MICROSCOPY (3.69 Å)
Cite:	Shared recognition mechanism for HIV-1 envelope-reactive V3 glycan broadly neutralizing B cell lineage maturation in humans and macaques To Be Published

8GDO

Crystal structure of DH1010 Fab
Descriptor:	DH1010 Fab Heavy Chain, DH1010 Fab Light chain
Authors:	Lindenberger, J, Acharya, P.
Deposit date:	2023-03-06
Release date:	2024-03-13
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Crystal structure of DH1010 Fab To Be Published

8DTK

Structure of RBD directed antibody DH1047 in complex with SARS-CoV-2 spike: Local refinement of RBD-Fab interace
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 Fab Heavy Chain, DH1047 Fab Light Chain, ...
Authors:	May, A.J, Manne, K, Acharya, P.
Deposit date:	2022-07-25
Release date:	2023-08-02
Last modified:	2024-02-28
Method:	ELECTRON MICROSCOPY (3.77 Å)
Cite:	Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates. Biorxiv, 2023

8DPZ

Local refinement of SARS-CoV-2 vaccine induced antibody DH1338 bound to SARS-CoV-2 HexaPro RBD Spike ectodomain
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1338 Fab Heavy Chain, DH1338 Fab Light Chain, ...
Authors:	Stalls, V, May, A.J, Acharya, P.
Deposit date:	2022-07-18
Release date:	2023-08-02
Method:	ELECTRON MICROSCOPY (3.38 Å)
Cite:	Local refinement of SARS-CoV-2 vaccine induced antibody Ab026500 bound to SARS-CoV-2 HexaPro RBD Spike ectodomain To Be Published

6X2A

SARS-CoV-2 u1S2q 1-RBD Up Spike Protein Trimer
Descriptor:	Spike glycoprotein
Authors:	Henderson, R, Acharya, P.
Deposit date:	2020-05-20
Release date:	2020-05-27
Last modified:	2021-08-04
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Controlling the SARS-CoV-2 spike glycoprotein conformation. Nat.Struct.Mol.Biol., 27, 2020

6X29

SARS-CoV-2 rS2d Down State Spike Protein Trimer
Descriptor:	Spike glycoprotein
Authors:	Henderson, R, Acharya, P.
Deposit date:	2020-05-20
Release date:	2020-05-27
Last modified:	2020-10-21
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Controlling the SARS-CoV-2 spike glycoprotein conformation. Nat.Struct.Mol.Biol., 27, 2020

6X2B

SARS-CoV-2 u1S2q 2-RBD Up Spike Protein Trimer
Descriptor:	Spike glycoprotein
Authors:	Henderson, R, Acharya, P.
Deposit date:	2020-05-20
Release date:	2020-05-27
Last modified:	2021-08-04
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Controlling the SARS-CoV-2 spike glycoprotein conformation. Nat.Struct.Mol.Biol., 27, 2020

6X2C

SARS-CoV-2 u1S2q All Down RBD State Spike Protein Trimer
Descriptor:	Spike glycoprotein
Authors:	Henderson, R, Acharya, P.
Deposit date:	2020-05-20
Release date:	2020-05-27
Last modified:	2021-07-07
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Controlling the SARS-CoV-2 spike glycoprotein conformation. Nat.Struct.Mol.Biol., 27, 2020

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