8DA7
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![BU of 8da7 by Molmil](/molmil-images/mine/8da7) | Coevolved affibody-Z domain pair LL1.c6 | Descriptor: | Immunoglobulin G-binding protein A, MALONATE ION, affibody LL1.FIFV | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAA
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![BU of 8daa by Molmil](/molmil-images/mine/8daa) | Coevolved affibody-Z domain pair LL2.c7 | Descriptor: | Affibody LL2.FIVK, Immunoglobulin G-binding protein A, MALONATE ION | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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8DAB
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![BU of 8dab by Molmil](/molmil-images/mine/8dab) | Coevolved affibody-Z domain pair LL2.c17 | Descriptor: | Affibody LL2.IVVY, Immunoglobulin G-binding protein A | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | Deposit date: | 2022-06-13 | Release date: | 2023-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.134 Å) | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science, 381, 2023
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7N3T
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![BU of 7n3t by Molmil](/molmil-images/mine/7n3t) | TrkA ECD complex with designed miniprotein ligand | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jude, K.M, Cao, L, Garcia, K.C. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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7RAA
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![BU of 7raa by Molmil](/molmil-images/mine/7raa) | Designed StabIL-2 seq15 | Descriptor: | Interleukin-2, MAGNESIUM ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RA9
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![BU of 7ra9 by Molmil](/molmil-images/mine/7ra9) | Designed StabIL-2 seq1 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | Deposit date: | 2021-06-30 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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5UTZ
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![BU of 5utz by Molmil](/molmil-images/mine/5utz) | Human IL-2/Fab complex | Descriptor: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | Authors: | Jude, K.M, Garcia, K.C. | Deposit date: | 2017-02-15 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
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6BJ3
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![BU of 6bj3 by Molmil](/molmil-images/mine/6bj3) | TCR55 in complex with HIV(Pol448-456)/HLA-B35 | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, HIV Pol B35 peptide, ... | Authors: | Jude, K.M, Sibener, L.V, Garcia, K.C. | Deposit date: | 2017-11-03 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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6BJ2
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![BU of 6bj2 by Molmil](/molmil-images/mine/6bj2) | TCR589 in complex with HIV(Pol448-456)/HLA-B35 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | Authors: | Jude, K.M, Sibener, L.V, Garcia, K.C. | Deposit date: | 2017-11-03 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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6BJ8
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![BU of 6bj8 by Molmil](/molmil-images/mine/6bj8) | TCR55 in complex with Pep20/HLA-B35 | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Jude, K.M, Sibener, L.V, Yang, X, Garcia, K.C. | Deposit date: | 2017-11-05 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174, 2018
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6MOH
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![BU of 6moh by Molmil](/molmil-images/mine/6moh) | Dimeric DARPin C_R3 complex with EpoR | Descriptor: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOI
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![BU of 6moi by Molmil](/molmil-images/mine/6moi) | Dimeric DARPin C_angle_R5 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.065 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOG
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![BU of 6mog by Molmil](/molmil-images/mine/6mog) | Dimeric DARPin C_R3 | Descriptor: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOE
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![BU of 6moe by Molmil](/molmil-images/mine/6moe) | Monomeric DARPin E2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOL
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![BU of 6mol by Molmil](/molmil-images/mine/6mol) | Monoextended DARPin M_R12 complex with EpoR | Descriptor: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.163 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOF
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![BU of 6mof by Molmil](/molmil-images/mine/6mof) | Monomeric DARPin G2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.894 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOJ
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![BU of 6moj by Molmil](/molmil-images/mine/6moj) | Dimeric DARPin A_angle_R5 complex with EpoR | Descriptor: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOK
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![BU of 6mok by Molmil](/molmil-images/mine/6mok) | Dimeric DARPin A_distance_R7 complex with EpoR | Descriptor: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (5.101 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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3CYU
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![BU of 3cyu by Molmil](/molmil-images/mine/3cyu) | Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon | Descriptor: | Carbonic anhydrase 2, MoMo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-y l)propanoic acid]-cryptophane-A, PoPo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-yl)propanoic acid]-cryptophane-A, ... | Authors: | Aaron, J.A, Jude, K.M, Di Costanzo, L, Christianson, D.W. | Deposit date: | 2008-04-26 | Release date: | 2008-05-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. J.Am.Chem.Soc., 130, 2008
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8ENT
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![BU of 8ent by Molmil](/molmil-images/mine/8ent) | Interleukin-21 signaling complex with IL-21R and IL-2Rg | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-09-30 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | A structural blueprint for interleukin-21 signal modulation. Cell Rep, 42, 2023
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7R86
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![BU of 7r86 by Molmil](/molmil-images/mine/7r86) | Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-06-26 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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7R85
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![BU of 7r85 by Molmil](/molmil-images/mine/7r85) | Structure of mouse Bai1 (ADGRB1) TSR3 domain | Descriptor: | Vasculostatin-120, alpha-D-mannopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-06-26 | Release date: | 2021-11-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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7R84
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![BU of 7r84 by Molmil](/molmil-images/mine/7r84) | |
8G04
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![BU of 8g04 by Molmil](/molmil-images/mine/8g04) | Structure of signaling thrombopoietin-MPL receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | Authors: | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | Deposit date: | 2023-01-31 | Release date: | 2023-08-30 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186, 2023
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6WDP
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![BU of 6wdp by Molmil](/molmil-images/mine/6wdp) | Interleukin 12 receptor subunit beta-1 | Descriptor: | GLYCEROL, Interleukin-12 receptor subunit beta-1, SULFATE ION | Authors: | Spangler, J.B, Thomas, C, Jude, K.M, Garcia, K.C. | Deposit date: | 2020-04-01 | Release date: | 2021-02-24 | Last modified: | 2021-12-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184, 2021
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