1KXA
| |
1IB4
| |
1KXC
| |
1KXD
| |
1KXE
| |
1KXB
| |
1KXF
| |
7KID
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | Descriptor: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | Authors: | Palte, R.L. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
|
|
7KIC
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | Descriptor: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | Authors: | Palte, R.L. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
|
|
7KIB
| PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | Descriptor: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Palte, R.L, Hayes, R.P. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
|
|
7EYS
| Complex structure of SptF with Fe, alpha-ketoglutarate, and andiconin D | Descriptor: | 2-OXOGLUTARIC ACID, 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, Andiconin D, ... | Authors: | Tao, H, Mori, T, Abe, I. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
7EYR
| Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF apo | Descriptor: | 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, FE (II) ION | Authors: | Tao, H, Mori, T, Abe, I. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
7EYT
| Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF with andilesin C and NOG | Descriptor: | 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, Andilesin C, FE (II) ION, ... | Authors: | Tao, H, Mori, T, Abe, I. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
7EYW
| Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF with terretonin C | Descriptor: | 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, FE (II) ION, N-OXALYLGLYCINE, ... | Authors: | Tao, H, Mori, T, Abe, I. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
7EYU
| Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF-N65T mutant with andiconin D | Descriptor: | 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, Andiconin D, FE (II) ION, ... | Authors: | Tao, H, Mori, T, Abe, I. | Deposit date: | 2021-06-01 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
7FCB
| SptF 9 residues truncated mutant | Descriptor: | 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF, FE (II) ION, N-OXALYLGLYCINE | Authors: | Hui, T, Mori, T, Abe, I. | Deposit date: | 2021-07-14 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF. Nat Commun, 13, 2022
|
|
5I76
| Crystal structure of FM318, a recombinant Fab adopted from cetuximab | Descriptor: | FM318_heavy_cahin, FM318_light_chain | Authors: | Sim, D.W, Kim, J.H, Seok, S.H, Seo, M.D, Kim, Y.P, Won, H.S. | Deposit date: | 2016-02-16 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.922 Å) | Cite: | Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor. Appl.Microbiol.Biotechnol., 100, 2016
|
|
2HNH
| Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III | Descriptor: | DNA polymerase III alpha subunit, PHOSPHATE ION | Authors: | Meindert, M.H, Georgescu, R.E, Lee, S, O'Donnell, M, Kuriyan, J. | Deposit date: | 2006-07-12 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III. Cell(Cambridge,Mass.), 126, 2006
|
|
7X1K
| |
3Q7G
| Crystal Structure of E2 domain of Human Amyloid Precursor-Like Protein 1 in complex with SOS (sucrose octasulfate) | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Amyloid-like protein 1 | Authors: | Xue, Y, Ha, Y. | Deposit date: | 2011-01-04 | Release date: | 2011-06-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate. J.Biol.Chem., 286, 2011
|
|
3QMK
| Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Amyloid-like protein 1, SULFATE ION | Authors: | Xue, Y, Ha, Y. | Deposit date: | 2011-02-04 | Release date: | 2011-10-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3Q61
| 3'-Fluoro Hexitol Nucleic Acid DNA Structure | Descriptor: | DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3') | Authors: | Seth, P.R, Allerson, C.R, Prakash, T.P, Siwkowski, A, Berdeja, A, Yu, J, Pallan, P.S, Watt, A.T, Gaus, H, Bhat, B, Egli, M, Swayze, E.E. | Deposit date: | 2010-12-30 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides. J.Am.Chem.Soc., 133, 2011
|
|
3S0X
| |
3Q7L
| |
2P22
| Structure of the Yeast ESCRT-I Heterotetramer Core | Descriptor: | Hypothetical 12.0 kDa protein in ADE3-SER2 intergenic region, Protein SRN2, SULFATE ION, ... | Authors: | Kostelansky, M.S, Hurley, J.H. | Deposit date: | 2007-03-06 | Release date: | 2007-06-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell(Cambridge,Mass.), 129, 2007
|
|