5URM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5urm by Molmil](/molmil-images/mine/5urm) | Crystal structure of human BRR2 in complex with T-1206548 | Descriptor: | 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Klein, M.G, Tjhen, R, Qin, L. | Deposit date: | 2017-02-11 | Release date: | 2017-07-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J. Med. Chem., 60, 2017
|
|
5URJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5urj by Molmil](/molmil-images/mine/5urj) | Crystal structure of human BRR2 in complex with T-3905516 | Descriptor: | 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Klein, M.G, Tjhen, R, Qin, L. | Deposit date: | 2017-02-10 | Release date: | 2017-07-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J. Med. Chem., 60, 2017
|
|
5URK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5urk by Molmil](/molmil-images/mine/5urk) | Crystal structure of human BRR2 in complex with T-3935799 | Descriptor: | 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Qin, L, Tjhen, R, Klein, M.G. | Deposit date: | 2017-02-10 | Release date: | 2017-07-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J. Med. Chem., 60, 2017
|
|
2D22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d22 by Molmil](/molmil-images/mine/2d22) | Crystal structure of covalent glycosyl-enzyme intermediate of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | Descriptor: | ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, SULFATE ION, ... | Authors: | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | Deposit date: | 2005-09-02 | Release date: | 2006-10-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
|
|
2D1Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d1z by Molmil](/molmil-images/mine/2d1z) | Crystal structure of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | Descriptor: | ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, SULFATE ION | Authors: | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | Deposit date: | 2005-09-02 | Release date: | 2006-10-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
|
|
2D20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d20 by Molmil](/molmil-images/mine/2d20) | Crystal structure of michaelis complex of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | Descriptor: | ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, P-NITROPHENOL, ... | Authors: | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | Deposit date: | 2005-09-02 | Release date: | 2006-10-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
|
|
2D23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d23 by Molmil](/molmil-images/mine/2d23) | Crystal structure of EP complex of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | Descriptor: | AZIDE ION, ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, ... | Authors: | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | Deposit date: | 2005-09-02 | Release date: | 2006-10-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
|
|
3DV3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dv3 by Molmil](/molmil-images/mine/3dv3) | MEK1 with PF-04622664 Bound | Descriptor: | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Kazmirski, S.L, Kothe, M, Ding, Y.-H. | Deposit date: | 2008-07-18 | Release date: | 2009-07-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
|
|
3DY7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dy7 by Molmil](/molmil-images/mine/3dy7) | X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP | Descriptor: | (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Ohren, J.F, Pavlovsky, A, Zhang, E. | Deposit date: | 2008-07-25 | Release date: | 2009-06-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
|
|
3H3A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h3a by Molmil](/molmil-images/mine/3h3a) | The complex structure of CCA-adding enzyme with CTP | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, TRNA nucleotidyl transferase-related protein | Authors: | Toh, Y, Tomita, K. | Deposit date: | 2009-04-16 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme Embo J., 28, 2009
|
|
3H38
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h38 by Molmil](/molmil-images/mine/3h38) | The structure of CCA-adding enzyme apo form II | Descriptor: | TRNA nucleotidyl transferase-related protein | Authors: | Toh, Y, Tomita, K. | Deposit date: | 2009-04-16 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme Embo J., 28, 2009
|
|
3H37
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h37 by Molmil](/molmil-images/mine/3h37) | The structure of CCA-adding enzyme apo form I | Descriptor: | TRNA nucleotidyl transferase-related protein | Authors: | Toh, Y, Tomita, K. | Deposit date: | 2009-04-16 | Release date: | 2009-10-13 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme Embo J., 28, 2009
|
|
2D24
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d24 by Molmil](/molmil-images/mine/2d24) | Crystal structure of ES complex of catalytic-site mutant xylanase from Streptomyces olivaceoviridis E-86 | Descriptor: | ENDO-1,4-BETA-D-XYLANASE, GLYCEROL, SULFATE ION, ... | Authors: | Suzuki, R, Kuno, A, Fujimoto, Z, Ito, S, Kawahara, S.I, Kaneko, S, Hasegawa, T, Taira, K. | Deposit date: | 2005-09-02 | Release date: | 2006-10-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86 J.Biochem., 146, 2009
|
|
3H39
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h39 by Molmil](/molmil-images/mine/3h39) | The complex structure of CCA-adding enzyme with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, TRNA nucleotidyl transferase-related protein | Authors: | Toh, Y, Tomita, K. | Deposit date: | 2009-04-16 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.854 Å) | Cite: | Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme Embo J., 28, 2009
|
|
1E74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e74 by Molmil](/molmil-images/mine/1e74) | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R11E | Descriptor: | ALPHA-CONOTOXIN IM1(R11E) | Authors: | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | Deposit date: | 2000-08-24 | Release date: | 2000-12-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist J.Mol.Biol., 304, 2000
|
|
1E76
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e76 by Molmil](/molmil-images/mine/1e76) | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT D5N | Descriptor: | ALPHA-CONOTOXIN IM1(D5N) | Authors: | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | Deposit date: | 2000-08-24 | Release date: | 2000-12-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist J.Mol.Biol., 304, 2000
|
|
1E75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e75 by Molmil](/molmil-images/mine/1e75) | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L | Descriptor: | ALPHA-CONOTOXIN IM1(R7L) | Authors: | Rogers, J.P, Luginbuhl, P, Pemberton, K, Harty, P, Wemmer, D.E, Stevens, R.C. | Deposit date: | 2000-08-24 | Release date: | 2000-12-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure-Activity Relationships in a Peptidic Alpha7 Nicotinic Acetylcholine Receptor Antagonist J.Mol.Biol., 304, 2000
|
|
2KHA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2kha by Molmil](/molmil-images/mine/2kha) | Solution Structure of a Pathogen Recognition Domain from a Lepidopteran Insect, Plodia interpunctella | Descriptor: | Beta-1,3-glucan-binding protein | Authors: | Dai, H, Hiromasa, Y, Fabrick, J, Vandervelde, D, Kanost, M, Krishnamoorthi, R. | Deposit date: | 2009-03-29 | Release date: | 2010-03-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An initial event in the insect innate immune response: structural and biological studies of interactions between beta-1,3-glucan and the N-terminal domain of beta-1,3-glucan recognition protein Biochemistry, 52, 2013
|
|
1L8O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1l8o by Molmil](/molmil-images/mine/1l8o) | Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase | Descriptor: | L-3-phosphoserine phosphatase, PHOSPHATE ION, SERINE | Authors: | Kim, H.Y, Heo, Y.S, Kim, J.H, Park, M.H, Moon, J, Park, S.Y, Lee, T.G, Jeon, Y.H, Ro, S, Hwang, K.Y. | Deposit date: | 2002-03-21 | Release date: | 2003-04-01 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase J.Biol.Chem., 277, 2002
|
|
1L8L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1l8l by Molmil](/molmil-images/mine/1l8l) | Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase | Descriptor: | D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID, L-3-phosphoserine phosphatase | Authors: | Kim, H.Y, Heo, Y.S, Kim, J.H, Park, M.H, Moon, J, Park, S.Y, Lee, T.G, Jeon, Y.H, Ro, S, Hwang, K.Y. | Deposit date: | 2002-03-21 | Release date: | 2003-04-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J.Biol.Chem., 277, 2002
|
|
3WG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wg5 by Molmil](/molmil-images/mine/3wg5) | 1510-N membrane-bound stomatin-specific protease K138A mutant in complex with a substrate peptide under heat treatment | Descriptor: | 441aa long hypothetical nfeD protein, CHLORIDE ION, GLYCEROL, ... | Authors: | Yokoyama, H, Fujii, S, Matsui, I. | Deposit date: | 2013-07-26 | Release date: | 2013-10-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and biochemical analysis of a thermostable membrane-bound stomatin-specific protease. J.Synchrotron Radiat., 20, 2013
|
|
1QP1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qp1 by Molmil](/molmil-images/mine/1qp1) | KAPPA VARIABLE LIGHT CHAIN | Descriptor: | BENCE-JONES KAPPA I ANTIBODY BRE (LIGHT CHAIN) | Authors: | Steinrauf, L.K. | Deposit date: | 1999-05-30 | Release date: | 1999-06-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Molecular structure of the amyloid-forming protein kappa I Bre. J.Biochem.(Tokyo), 125, 1999
|
|
8FZA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fza by Molmil](/molmil-images/mine/8fza) | Class I type III preQ1 riboswitch from E. coli | Descriptor: | 7-DEAZA-7-AMINOMETHYL-GUANINE, MANGANESE (II) ION, PreQ1 Riboswitch (30-MER) | Authors: | Wedekind, J.E, Schroeder, G.M, Jenkins, J.L. | Deposit date: | 2023-01-27 | Release date: | 2023-08-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function analysis of a type III preQ 1 -I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence. J.Biol.Chem., 299, 2023
|
|
8GJY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8gjy by Molmil](/molmil-images/mine/8gjy) | Structure of a cGAS-like receptor Sp-cGLR1 from S. pistillata | Descriptor: | cGAS-like receptor 1 | Authors: | Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. | Deposit date: | 2023-03-16 | Release date: | 2023-07-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
|
|
8GJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8gjw by Molmil](/molmil-images/mine/8gjw) | Structure of a cGAS-like receptor Cv-cGLR1 from C. virginica | Descriptor: | SULFATE ION, cGAS-like receptor 1 | Authors: | Li, Y, Morehouse, B.R, Slavik, K.M, Liu, J, Toyoda, H, Kranzusch, P.J. | Deposit date: | 2023-03-16 | Release date: | 2023-07-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
|
|