8QAR
 
 | | Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98 | | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, Bromodomain-containing protein 4 | | Authors: | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QAZ
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 3 | | Descriptor: | 2-[4-[4-ethanoyl-5-methyl-3-(3-methylbutyl)-1~{H}-pyrrol-2-yl]-1,3-thiazol-2-yl]guanidine, NITRATE ION, Peregrin | | Authors: | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QB2
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 79 | | Descriptor: | 1-[2-methyl-4-(3-methylbutyl)-5-(2-piperazin-1-yl-1,3-thiazol-4-yl)-1~{H}-pyrrol-3-yl]ethanone, NITRATE ION, Peregrin | | Authors: | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | Deposit date: | 2023-08-24 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QB0
 | | Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 2 | | Descriptor: | 2-[4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-2~{H}-isoindol-1-yl)-1,3-thiazol-2-yl]guanidine, NITRATE ION, Peregrin | | Authors: | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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8QAL
 | | Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 83 | | Descriptor: | 1,2-ETHANEDIOL, 2-[4-(3-methyl-4-oxidanylidene-2,5,6,7-tetrahydroisoindol-1-yl)-1,3-thiazol-2-yl]guanidine, Bromodomain-containing protein 4 | | Authors: | Dalle Vedove, A, Cazzanelli, G, Lolli, G. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
Protein Sci., 33, 2024
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6EPR
 | | The ATAD2 bromodomain in complex with compound UZH-DS15 | | Descriptor: | (~{N}~{Z},2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-3~{H}-1,3-thiazol-2-ylidene]-1-[2-[4,4-bis(fluoranyl)cyclohexyl]ethyl]piperazine-2-carboxamide, ATPase family AAA domain-containing protein 2, SULFATE ION | | Authors: | Sledz, P, Caflisch, A. | | Deposit date: | 2017-10-12 | | Release date: | 2018-10-31 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.053 Å) | | Cite: | Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
To Be Published
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6EPW
 | | The ATAD2 bromodomain in complex with compound UZH-DU32 | | Descriptor: | (2~{R})-~{N}-[5-[3,5-bis(oxidanyl)phenyl]-4-ethanoyl-1,3-thiazol-2-yl]-2-carbamimidamido-propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION | | Authors: | Sledz, P, Caflisch, A. | | Deposit date: | 2017-10-12 | | Release date: | 2018-10-31 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.924 Å) | | Cite: | Hitting a moving target: simulation and crystallography study of ATAD2 bromodomain blockers
To Be Published
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5E0R
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6QST
 | | Structure of CREBBP bromodomain with compound 2 bound | | Descriptor: | CREB-binding protein, ~{N}-[3-(3-azanyl-5-methyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide | | Authors: | Zhu, J, Sledz, P, Caflisch, A. | | Deposit date: | 2019-02-22 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of CREBBP bromodomain with compound 2 bound
To Be Published
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