7XM0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xm0 by Molmil](/molmil-images/mine/7xm0) | |
7ECW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ecw by Molmil](/molmil-images/mine/7ecw) | The Csy-AcrIF14-dsDNA complex | Descriptor: | 54-MER DNA, AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, ... | Authors: | Zhang, L.X, Feng, Y. | Deposit date: | 2021-03-13 | Release date: | 2021-11-17 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Res., 49, 2021
|
|
7ECV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ecv by Molmil](/molmil-images/mine/7ecv) | The Csy-AcrIF14 complex | Descriptor: | AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | Authors: | Zhang, L.X, Feng, Y. | Deposit date: | 2021-03-13 | Release date: | 2021-11-17 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Res., 49, 2021
|
|
7C6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c6s by Molmil](/molmil-images/mine/7c6s) | |
7C6U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c6u by Molmil](/molmil-images/mine/7c6u) | Crystal structure of SARS-CoV-2 complexed with GC376 | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | Authors: | Fu, L, Feng, Y, Qi, J, Gao, F.G. | Deposit date: | 2020-05-22 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020
|
|
7D1O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d1o by Molmil](/molmil-images/mine/7d1o) | Crystal structure of SARS-Cov-2 main protease with narlaprevir | Descriptor: | (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | Authors: | Fu, L.F, Feng, Y, Qi, J.X. | Deposit date: | 2020-09-15 | Release date: | 2020-09-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir. Signal Transduct Target Ther, 6, 2021
|
|
7ELM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7elm by Molmil](/molmil-images/mine/7elm) | Structure of Csy-AcrIF24 | Descriptor: | AcrIF24, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | Authors: | Zhang, L, Feng, Y. | Deposit date: | 2021-04-12 | Release date: | 2022-04-20 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24. Nat Commun, 13, 2022
|
|
7ELN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eln by Molmil](/molmil-images/mine/7eln) | Structure of Csy-AcrIF24-dsDNA | Descriptor: | 54-MER DNA, AcrIF24, CRISPR type I-F/YPEST-associated protein Csy2, ... | Authors: | Zhang, L, Feng, Y. | Deposit date: | 2021-04-12 | Release date: | 2022-04-20 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24. Nat Commun, 13, 2022
|
|
7EQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eqg by Molmil](/molmil-images/mine/7eqg) | Structure of Csy-AcrIF5 | Descriptor: | AcrIF5, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | Authors: | Zhang, L, Feng, Y. | Deposit date: | 2021-05-01 | Release date: | 2022-03-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition. Nat.Chem.Biol., 18, 2022
|
|
7C78
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c78 by Molmil](/molmil-images/mine/7c78) | |
7EGN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7egn by Molmil](/molmil-images/mine/7egn) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with N-imidazolyl-hexanoyl-L-phenylalanine and hydroxylamine | Descriptor: | (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... | Authors: | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | Deposit date: | 2021-03-24 | Release date: | 2021-08-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450 Acs Catalysis, 11, 2021
|
|
7D7D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d7d by Molmil](/molmil-images/mine/7d7d) | CryoEM structure of gp45-dependent transcription activation complex | Descriptor: | DNA (nontemplate strand), DNA (template strand), DNA polymerase clamp, ... | Authors: | Shi, J, Wen, A, Jin, S, Feng, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Transcription activation by a sliding clamp. Nat Commun, 12, 2021
|
|
7D7C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d7c by Molmil](/molmil-images/mine/7d7c) | CryoEM structure of gp55-dependent RNA polymerase-promoter open complex | Descriptor: | DNA (nontemplate strand), DNA (template strand), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Shi, J, Wen, A, Jin, S, Feng, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Transcription activation by a sliding clamp. Nat Commun, 12, 2021
|
|
7F75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f75 by Molmil](/molmil-images/mine/7f75) | Cryo-EM structure of Spx-dependent transcription activation complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Feng, Y, Shi, J. | Deposit date: | 2021-06-28 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
|
|
7CG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cg5 by Molmil](/molmil-images/mine/7cg5) | |
7CG8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cg8 by Molmil](/molmil-images/mine/7cg8) | Structure of the sensor domain (short construct) of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, ACETATE ION, Anti-sigma factor RsgI, ... | Authors: | Dong, S, Feng, Y. | Deposit date: | 2020-06-30 | Release date: | 2021-06-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the sensor domain of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens To Be Published
|
|
7CG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cg1 by Molmil](/molmil-images/mine/7cg1) | |
7EIN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ein by Molmil](/molmil-images/mine/7ein) | SARS-CoV-2 main proteinase complex with microbial metabolite leupeptin | Descriptor: | 3C-like proteinase, leupeptin | Authors: | Fu, L.F, Feng, Y, Qi, J.X, Gao, G.F. | Deposit date: | 2021-03-31 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. Mbio, 12, 2021
|
|
7ELE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ele by Molmil](/molmil-images/mine/7ele) | |
7ELD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7eld by Molmil](/molmil-images/mine/7eld) | |
7DM4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dm4 by Molmil](/molmil-images/mine/7dm4) | Solution structure of ARID4B Tudor domain | Descriptor: | AT-rich interactive domain-containing protein 4B | Authors: | Ren, J, Yao, H, Hu, W, Perrett, S, Feng, Y, Gong, W. | Deposit date: | 2020-12-02 | Release date: | 2021-03-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the DNA-binding activity of human ARID4B Tudor domain. J.Biol.Chem., 296, 2021
|
|
7MWH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mwh by Molmil](/molmil-images/mine/7mwh) | Crystal structure of BAZ2A with DNA | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*CP*GP*GP*AP*AP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*TP*TP*CP*CP*G)-3'), ... | Authors: | Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-05-17 | Release date: | 2022-08-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Crystal structure of the BAZ2B TAM domain. Heliyon, 8, 2022
|
|
6JJS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jjs by Molmil](/molmil-images/mine/6jjs) | Crystal structure of an enzyme from Penicillium herquei in condition2 | Descriptor: | ACETATE ION, PhnH | Authors: | Fen, Y, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | Deposit date: | 2019-02-26 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei. Biochem.Biophys.Res.Commun., 516, 2019
|
|
6JJT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jjt by Molmil](/molmil-images/mine/6jjt) | Crystal structure of an enzyme from Penicillium herquei in condition1 | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, PhnH | Authors: | Fen, Y, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | Deposit date: | 2019-02-26 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei. Biochem.Biophys.Res.Commun., 516, 2019
|
|
7S1N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s1n by Molmil](/molmil-images/mine/7s1n) | |