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1WQ1
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BU of 1wq1 by Molmil
RAS-RASGAP COMPLEX
分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, H-RAS, ...
著者Scheffzek, K, Ahmadian, M.R, Kabsch, W, Wiesmueller, L, Lautwein, A, Schmitz, F, Wittinghofer, A.
登録日1997-07-03
公開日1998-07-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science, 277, 1997
1F5N
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BU of 1f5n by Molmil
HUMAN GUANYLATE BINDING PROTEIN-1 IN COMPLEX WITH THE GTP ANALOGUE, GMPPNP.
分子名称: INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Prakash, B, Renault, L, Praefcke, G.J.K, Herrmann, C, Wittinghofer, A.
登録日2000-06-15
公開日2000-09-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism.
EMBO J., 19, 2000
5P21
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BU of 5p21 by Molmil
REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Pai, E.F, Wittinghofer, A, Kabsch, W.
登録日1990-04-30
公開日1992-01-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
EMBO J., 9, 1990
821P
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BU of 821p by Molmil
THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Scheidig, A.J, Krengel, U, Pai, E.F, Kabsch, W, Wittinghofer, A, Goody, R.S.
登録日1993-03-29
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
621P
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BU of 621p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
721P
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BU of 721p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
5L7K
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BU of 5l7k by Molmil
The crystal structure of myristoylated NPHP3 peptide in complex with UNC119a
分子名称: GLY-THR-ALA-SER-SER-LEU, MYRISTIC ACID, Protein unc-119 homolog A
著者Fansa, E.K, Jaiswal, M, Wittinghofer, A.
登録日2016-06-03
公開日2016-08-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.
J.Biol.Chem., 291, 2016
4F0G
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BU of 4f0g by Molmil
Crystal Structure of the Roco4 Kinase Domain from D. discoideum
分子名称: Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-04
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F0F
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Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-04
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1M
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BU of 4f1m by Molmil
Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum.
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-07
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1O
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BU of 4f1o by Molmil
Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-07
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1T
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BU of 4f1t by Molmil
Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152
分子名称: (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Serine/threonine-protein kinase roco4
著者Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
登録日2012-05-07
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
421P
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BU of 421p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U, John, J, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
521P
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BU of 521p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: GUANOSINE-5'-TRIPHOSPHATE, H-RAS P21 PROTEIN, MAGNESIUM ION
著者Schlichting, I, Krengel, U, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1GUA
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BU of 1gua by Molmil
HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131
分子名称: C-RAF1, CALCIUM ION, MAGNESIUM ION, ...
著者Nassar, N, Wittinghofer, A.
登録日1996-06-18
公開日1997-01-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Ras/Rap effector specificity determined by charge reversal.
Nat.Struct.Biol., 3, 1996
1GNP
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BU of 1gnp by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER
著者Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1NF1
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BU of 1nf1 by Molmil
THE GAP RELATED DOMAIN OF NEUROFIBROMIN
分子名称: PROTEIN (NEUROFIBROMIN)
著者Scheffzek, K, Ahmadian, M.R, Wiesmueller, L, Kabsch, W, Stege, P, Schmitz, F, Wittinghofer, A.
登録日1998-07-08
公開日1999-07-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of the GAP-related domain from neurofibromin and its implications.
EMBO J., 17, 1998
3GEI
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BU of 3gei by Molmil
Crystal structure of MnmE from Chlorobium tepidum in complex with GCP
分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, tRNA modification GTPase mnmE
著者Meyer, S, Wittinghofer, A.
登録日2009-02-25
公開日2009-10-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy
Plos Biol., 7, 2009
4QAM
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BU of 4qam by Molmil
Crystal Structure of the RPGR RCC1-like domain in complex with the RPGR-interacting domain of RPGRIP1
分子名称: GLYCEROL, MAGNESIUM ION, X-linked retinitis pigmentosa GTPase regulator, ...
著者Remans, K, Buerger, M, Vetter, I.R, Wittinghofer, A.
登録日2014-05-05
公開日2014-07-30
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献C2 domains as protein-protein interaction modules in the ciliary transition zone.
Cell Rep, 8, 2014
2RGF
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BU of 2rgf by Molmil
RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES
分子名称: RALGEF-RBD
著者Geyer, M, Herrmann, C, Wittinghofer, A, Kalbitzer, H.R.
登録日1997-02-13
公開日1998-03-04
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nat.Struct.Biol., 4, 1997
1GNQ
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BU of 1gnq by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
著者Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1GNR
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BU of 1gnr by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
著者Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
4GOJ
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BU of 4goj by Molmil
The Crystal Structure of full length Arl3GppNHp in complex with UNC119a
分子名称: ADP-ribosylation factor-like protein 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A.
登録日2012-08-20
公開日2012-09-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
4GOK
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BU of 4gok by Molmil
The Crystal structure of Arl2GppNHp in complex with UNC119a
分子名称: ADP-ribosylation factor-like protein 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A.
登録日2012-08-20
公開日2012-09-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Embo J., 31, 2012
1K5D
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BU of 1k5d by Molmil
Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex
分子名称: GTP-binding nuclear protein RAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R.
登録日2001-10-10
公開日2002-02-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002

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