Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4PBG
DownloadVisualize
BU of 4pbg by Molmil
6-PHOSPHO-BETA-GALACTOSIDASE FORM-CST
分子名称: 6-O-phosphono-beta-D-galactopyranose, 6-PHOSPHO-BETA-D-GALACTOSIDASE
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
3PBG
DownloadVisualize
BU of 3pbg by Molmil
6-PHOSPHO-BETA-GALACTOSIDASE FORM-C
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
1FLT
DownloadVisualize
BU of 1flt by Molmil
VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, De Vos, A.M.
登録日1997-11-20
公開日1999-01-13
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
2PBG
DownloadVisualize
BU of 2pbg by Molmil
6-PHOSPHO-BETA-D-GALACTOSIDASE FORM-B
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
1WWW
DownloadVisualize
BU of 1www by Molmil
NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR
分子名称: PROTEIN (NERVE GROWTH FACTOR), PROTEIN (TRKA RECEPTOR)
著者Wiesmann, C, Ultsch, M.H, De Vos, A.M.
登録日1999-03-12
公開日1999-09-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Nature, 401, 1999
1PBG
DownloadVisualize
BU of 1pbg by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF 6-PHOSPHO-BETA GALACTOSIDASE FROM LACTOCOCCUS LACTIS
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1995-09-14
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The three-dimensional structure of 6-phospho-beta-galactosidase from Lactococcus lactis.
Structure, 3, 1995
1VPP
DownloadVisualize
BU of 1vpp by Molmil
COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
分子名称: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
著者Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M.
登録日1998-10-09
公開日1999-02-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
2ICC
DownloadVisualize
BU of 2icc by Molmil
Extracellular Domain of CRIg
分子名称: V-set and immunoglobulin domain-containing protein 4
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
DownloadVisualize
BU of 2icf by Molmil
CRIg bound to C3b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICE
DownloadVisualize
BU of 2ice by Molmil
CRIg bound to C3c
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
1T49
DownloadVisualize
BU of 1t49 by Molmil
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, MAGNESIUM ION, Protein-tyrosine phosphatase, ...
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-28
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B.
Nat.Struct.Mol.Biol., 11, 2004
1T4J
DownloadVisualize
BU of 1t4j by Molmil
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Protein-tyrosine phosphatase, non-receptor type 1
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-29
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
1T48
DownloadVisualize
BU of 1t48 by Molmil
Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID DIMETHYLAMIDE, Protein-tyrosine phosphatase, non-receptor type 1
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Erlanson, D.A, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-28
公開日2004-07-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
3DBS
DownloadVisualize
BU of 3dbs by Molmil
Structure of PI3K gamma in complex with GDC0941
分子名称: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Wiesmann, C, Ultsch, M.
登録日2008-06-02
公開日2008-06-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
J.Med.Chem., 51, 2008
1QTY
DownloadVisualize
BU of 1qty by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, de Vos, A.M.
登録日1999-06-29
公開日2000-01-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
6FFS
DownloadVisualize
BU of 6ffs by Molmil
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
分子名称: 3C Protease, SULFATE ION, ~{N}-[(2~{S},5~{S},14~{S})-2-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-9-methyl-3,8,15-tris(oxidanylidene)-1,4,9-triazacyclopentadec-14-yl]-5-methyl-1,2-oxazole-3-carboxamide
著者Wiesmann, C, Farady, C.
登録日2018-01-09
公開日2018-02-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6FFN
DownloadVisualize
BU of 6ffn by Molmil
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
分子名称: 3C protease, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Wiesmann, C, Farady, C.
登録日2018-01-08
公開日2018-02-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
2FJH
DownloadVisualize
BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJF
DownloadVisualize
BU of 2fjf by Molmil
Structure of the G6 Fab, a phage derived VEGF binding Fab
分子名称: Heavy Chain of a VEGF binding Antibody, Light Chain of a VEGF binding Antibody
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJG
DownloadVisualize
BU of 2fjg by Molmil
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
3H0Z
DownloadVisualize
BU of 3h0z by Molmil
Aurora A in complex with a bisanilinopyrimidine
分子名称: 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
3H10
DownloadVisualize
BU of 3h10 by Molmil
Aurora A inhibitor complex
分子名称: 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
3H0Y
DownloadVisualize
BU of 3h0y by Molmil
Aurora A in complex with a bisanilinopyrimidine
分子名称: 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
3COH
DownloadVisualize
BU of 3coh by Molmil
Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
分子名称: 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one, Serine/threonine-protein kinase 6
著者Wiesmann, C, Raswson, T.E, Cochran, A.G.
登録日2008-03-28
公開日2009-02-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.
J.Med.Chem., 51, 2008
1WWB
DownloadVisualize
BU of 1wwb by Molmil
LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR
分子名称: PROTEIN (Brain Derived Neurotrophic Factor Receptor TrkB)
著者Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M.
登録日1999-05-03
公開日1999-07-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999

222624

件を2024-07-17に公開中

PDB statisticsPDBj update infoContact PDBjnumon