1OQ5
 
 | | CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR | | 分子名称: | 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, Carbonic anhydrase II, ZINC ION | | 著者 | Weber, A, Casini, A, Heine, A, Kuhn, D, Supuran, C.T, Scozzafava, A, Klebe, G. | | 登録日 | 2003-03-07 | | 公開日 | 2004-03-23 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
J.Med.Chem., 47, 2004
|
|
5K1X
 | |
5K1P
 | |
4CS4
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in complex with AMPPNP | | 分子名称: | 1,2-ETHANEDIOL, 2-{[dihydroxy(4-aminoethylphenyl)-{4}-sulfanyl]amino}-3-hydroxypropanoic acid, MAGNESIUM ION, ... | | 著者 | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | 登録日 | 2014-03-04 | | 公開日 | 2014-04-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.349 Å) | | 主引用文献 | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
|
|
4CS2
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in its apo form | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRROLYSINE--TRNA LIGASE | | 著者 | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | 登録日 | 2014-03-04 | | 公開日 | 2014-04-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
|
|
4CS3
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in complex with an adenylated furan-bearing noncanonical amino acid and pyrophosphate | | 分子名称: | 1,2-ETHANEDIOL, 2-(furan-2-yl)ethyl hydrogen carbonate, ADENOSINE MONOPHOSPHATE, ... | | 著者 | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | 登録日 | 2014-03-04 | | 公開日 | 2014-04-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
|
|
5OE7
 | |
8OME
 | |
8OMD
 | |
8OMF
 | |
8OMK
 | |
8OMJ
 | | hKHK-C in complex with compound 28 | | 分子名称: | Ketohexokinase, SULFATE ION, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]methoxy-methyl-phosphinic acid | | 著者 | Pautsch, A, Ebenhoch, R. | | 登録日 | 2023-03-31 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | | 主引用文献 | Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
To Be Published
|
|
8OMG
 | | Crystal structure of mKHK (apo) | | 分子名称: | Ketohexokinase | | 著者 | Ebenhoch, E, Pautsch, P. | | 登録日 | 2023-03-31 | | 公開日 | 2023-09-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Acta Crystallogr D Struct Biol, 79, 2023
|
|
3DEN
 | | Structure of E. coli DHDPS mutant Y107W | | 分子名称: | Dihydrodipicolinate synthase, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Pearce, F.G, Gerrard, J.A, Perugini, M.A, Jameson, G.B. | | 登録日 | 2008-06-10 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme
Biochemistry, 47, 2008
|
|
