4CS3

Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in complex with an adenylated furan-bearing noncanonical amino acid and pyrophosphate

Summary for 4CS3

• Entry DOI: 10.2210/pdb4cs3/pdb
• Related: 4CS2 4CS4
• Descriptor: PYRROLYSINE--TRNA LIGASE, LYSINE, ADENOSINE MONOPHOSPHATE, ... (8 entities in total)
• Functional Keywords: ligase, aminoacyl-trna synthetase, pyrrolysyl-trna-synthetase, noncanonical amino acids, furans, crosslinking reactions
• Biological source: METHANOSARCINA MAZEI
• Cellular location: Cytoplasm (By similarity): Q8PWY1
• Total number of polymer chains: 1
• Total formula weight: 32673.59

Authors

Schmidt, M.J.,Weber, A.,Pott, M.,Welte, W.,Summerer, D. (deposition date: 2014-03-04, release date: 2014-04-30, Last modification date: 2024-05-08)

• Primary citation: Schmidt, M.J.,Weber, A.,Pott, M.,Welte, W.,Summerer, D.; Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.; Chembiochem, 15:1755-, 2014; PubMed: 24737732; DOI: 10.1002/CBIC.201402006

Experimental method

X-RAY DIFFRACTION (1.499 Å)