3HJF
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![BU of 3hjf by Molmil](/molmil-images/mine/3hjf) | Crystal structure of T. thermophilus Argonaute E546 mutant protein complexed with DNA guide strand and 15-nt RNA target strand | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-05-21 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.056 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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3HK2
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![BU of 3hk2 by Molmil](/molmil-images/mine/3hk2) | Crystal structure of T. thermophilus Argonaute N478 mutant protein complexed with DNA guide strand and 19-nt RNA target strand | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-05-22 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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8XIR
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![BU of 8xir by Molmil](/molmil-images/mine/8xir) | Structure of pasireotide-SSTR3 G protein complex | 分子名称: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8XIP
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![BU of 8xip by Molmil](/molmil-images/mine/8xip) | Structure of Pasireotide-SSTR1 G protein complex | 分子名称: | 004-DTR-LYS-TY5-PHE-A1D5E, G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8XIO
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![BU of 8xio by Molmil](/molmil-images/mine/8xio) | Structure of L797591-SSTR1 G protein complex | 分子名称: | (2~{S})-~{N}-[(4~{S})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide, G-alpha-i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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2FSZ
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![BU of 2fsz by Molmil](/molmil-images/mine/2fsz) | |
4FAE
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![BU of 4fae by Molmil](/molmil-images/mine/4fae) | Substrate p2/NC in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant | 分子名称: | HIV-1 protease, Substrate p2/NC peptide | 著者 | Wang, Y, Dewdney, T.G, Liu, Z, Reiter, S.J, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | 登録日 | 2012-05-22 | 公開日 | 2012-08-29 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease. Biology (Basel), 1, 2012
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6DFX
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![BU of 6dfx by Molmil](/molmil-images/mine/6dfx) | human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, Y, Dai, S. | 登録日 | 2018-05-15 | 公開日 | 2019-04-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol, 4, 2019
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6DFQ
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![BU of 6dfq by Molmil](/molmil-images/mine/6dfq) | mouse diabetogenic TCR I.29 | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, TCR alpha chain, ... | 著者 | Wang, Y, Dai, S. | 登録日 | 2018-05-15 | 公開日 | 2019-04-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol, 4, 2019
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6DFV
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![BU of 6dfv by Molmil](/molmil-images/mine/6dfv) | Mouse diabetogenic TCR 8F10 | 分子名称: | 1,2-ETHANEDIOL, TCR alpha chain, TCR beta chain | 著者 | Wang, Y, Dai, S. | 登録日 | 2018-05-15 | 公開日 | 2019-04-17 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol, 4, 2019
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7REI
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![BU of 7rei by Molmil](/molmil-images/mine/7rei) | The crystal structure of nickel bound human ADO C18S C239S variant | 分子名称: | 2-aminoethanethiol dioxygenase, GLYCEROL, NICKEL (II) ION | 著者 | Wang, Y, Shin, I, Li, J, Liu, A. | 登録日 | 2021-07-12 | 公開日 | 2021-09-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor. J.Biol.Chem., 297, 2021
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3KCU
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![BU of 3kcu by Molmil](/molmil-images/mine/3kcu) | Structure of formate channel | 分子名称: | 2-(6-(2-CYCLOHEXYLETHOXY)-TETRAHYDRO-4,5-DIHYDROXY-2(HYDROXYMETHYL)-2H-PYRAN-3-YLOXY)-TETRAHYDRO-6(HYDROXYMETHYL)-2H-PY RAN-3,4,5-TRIOL, Probable formate transporter 1 | 著者 | Wang, Y, Huang, Y, Wang, J, Yan, N, Shi, Y. | 登録日 | 2009-10-22 | 公開日 | 2009-12-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.243 Å) | 主引用文献 | Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel Nature, 462, 2009
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3KCV
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![BU of 3kcv by Molmil](/molmil-images/mine/3kcv) | Structure of formate channel | 分子名称: | Probable formate transporter 1 | 著者 | Wang, Y, Huang, Y, Wang, J, Yan, N, Shi, Y. | 登録日 | 2009-10-22 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.198 Å) | 主引用文献 | Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel Nature, 462, 2009
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8GAP
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![BU of 8gap by Molmil](/molmil-images/mine/8gap) | Structure of LARP7 protein p65-telomerase RNA complex in telomerase | 分子名称: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | 著者 | Wang, Y, He, Y, Wang, Y, Yang, Y, Singh, M, Eichhorn, C.D, Zhou, Z.H, Feigon, J. | 登録日 | 2023-02-23 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. J.Mol.Biol., 435, 2023
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6XJV
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![BU of 6xjv by Molmil](/molmil-images/mine/6xjv) | MCU holocomplex in High-calcium state | 分子名称: | Calcium uniporter protein, mitochondrial, Calcium uptake protein 1, ... | 著者 | Wang, Y, Jiang, Y. | 登録日 | 2020-06-24 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | 主引用文献 | Structural insights into the Ca 2+ -dependent gating of the human mitochondrial calcium uniporter. Elife, 9, 2020
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6XJX
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![BU of 6xjx by Molmil](/molmil-images/mine/6xjx) | MCU holocomplex in Low-calcium blocking state | 分子名称: | Calcium uniporter protein, mitochondrial, Calcium uptake protein 1, ... | 著者 | Wang, Y, Jiang, Y. | 登録日 | 2020-06-24 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural insights into the Ca 2+ -dependent gating of the human mitochondrial calcium uniporter. Elife, 9, 2020
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6O58
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![BU of 6o58 by Molmil](/molmil-images/mine/6o58) | Human MCU-EMRE complex, dimer of channel | 分子名称: | CALCIUM ION, Calcium uniporter protein, mitochondrial, ... | 著者 | Wang, Y, Bai, X, Jiang, Y. | 登録日 | 2019-03-01 | 公開日 | 2019-05-22 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter. Cell, 177, 2019
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6O5B
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![BU of 6o5b by Molmil](/molmil-images/mine/6o5b) | Monomer of a cation channel | 分子名称: | CALCIUM ION, Calcium uniporter protein, mitochondrial, ... | 著者 | Wang, Y, Bai, X, Jiang, Y. | 登録日 | 2019-03-01 | 公開日 | 2019-05-22 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter. Cell, 177, 2019
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8E9E
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![BU of 8e9e by Molmil](/molmil-images/mine/8e9e) | Rat protein farnesyltransferase in complex with FPP and inhibitor 2f | 分子名称: | (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2022-08-26 | 公開日 | 2022-10-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.844 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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4ZOL
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![BU of 4zol by Molmil](/molmil-images/mine/4zol) | Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex | 分子名称: | (2R,4R)-4-{[(2-{(1R,3R)-1-(acetyloxy)-4-methyl-3-[methyl(N-{[(2S)-1-methylpiperidin-2-yl]carbonyl}-D-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Zhang, R. | 登録日 | 2015-05-06 | 公開日 | 2016-07-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol., 89, 2016
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5KQE
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![BU of 5kqe by Molmil](/molmil-images/mine/5kqe) | |
5BMV
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![BU of 5bmv by Molmil](/molmil-images/mine/5bmv) | CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX | 分子名称: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Chen, Q, Zhang, R. | 登録日 | 2015-05-23 | 公開日 | 2016-07-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. Mol.Pharmacol., 89, 2016
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8D5P
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![BU of 8d5p by Molmil](/molmil-images/mine/8d5p) | Mouse TCR TG6 | 分子名称: | TCR-alpha, TCR-beta | 著者 | Wang, Y, Dai, S. | 登録日 | 2022-06-05 | 公開日 | 2022-09-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Peptide Centric V beta Specific Germline Contacts Shape a Specialist T Cell Response. Front Immunol, 13, 2022
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8D5N
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![BU of 8d5n by Molmil](/molmil-images/mine/8d5n) | Crystal structure of Ld-HF10 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | 著者 | Wang, Y, Dai, S. | 登録日 | 2022-06-05 | 公開日 | 2022-09-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Peptide Centric V beta Specific Germline Contacts Shape a Specialist T Cell Response. Front Immunol, 13, 2022
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8D5Q
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![BU of 8d5q by Molmil](/molmil-images/mine/8d5q) | TCR TG6 in complex with Ld-HF10 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Dense granule protein 6, HF10 peptide, ... | 著者 | Wang, Y, Dai, S. | 登録日 | 2022-06-05 | 公開日 | 2022-09-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Peptide Centric V beta Specific Germline Contacts Shape a Specialist T Cell Response. Front Immunol, 13, 2022
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