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8Q0E
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Crystal Structure of the N-terminal Domain of Variant Surface Glycoprotein 545 (VSG545) of Trypanosome brucei brucei Lister 427
分子名称: Variant surface glycoprotein 545
著者van Straaten, M, Stebbins, C.E.
登録日2023-07-28
公開日2023-09-13
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK7
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Variant Surface Glycoprotein VSG558 NTD
分子名称: Variant surface glycoprotein 558, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zeelen, J.P, Stebbins, C.E, van Straaten, M, Zhong, J.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
6Z8G
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Crystal structure of VSG13 soaked in 0.5 M used to phase VSG13 to solve the structure.
分子名称: BROMIDE ION, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z8H
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Crystal structure of Variant Surface Glycoprotein VSG13
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Variant surface glycoprotein MITat 1.13, ...
著者Stebbins, C.E, Hempelmann, A, Van Straaten, M, Zeelen, J.
登録日2020-06-02
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
7P56
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Variant Surface Glycoprotein 2 (VSG2, MiTat1.2, VSG221) Bound to Calcium
分子名称: CALCIUM ION, Variant surface glycoprotein MITAT 1.2, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.735 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
7P5D
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Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) mutant (serine 317 and 319 to alanine)
分子名称: Variant surface glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
7P57
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VSG2 mutant structure lacking the calcium binding pocket
分子名称: Variant surface glycoprotein MITAT 1.2, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.961 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
7P59
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Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) with two O-linked post-translational modifications
分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gkeka, A, Arest-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
7P5B
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Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) mutant (serine 319 to alanine), single O-linked glycosylated at Ser317
分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
7P5A
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Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) mutant (serine 317 to alanine), single O-linked glycosylated at Ser319
分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Immunodominant surface epitopes power immune evasion in the African trypanosome.
Cell Rep, 42, 2023
8OK8
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Variant Surface Glycoprotein VSG615
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Variant surface glycoprotein 615, ...
著者Zeelen, J.P, Stebbins, C.E, Chandra, M.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
7QT2
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Antibody FenAb208 - fentanyl complex
分子名称: Antibody heavy chain, Antibody light chain, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2022-01-14
公開日2023-05-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Cell Rep, 42, 2023
7QT0
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Antibody FenAb136 - fentanyl complex
分子名称: 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid, Antibody heavy chain, Antibody light chain
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2022-01-14
公開日2023-05-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Cell Rep, 42, 2023
7QT4
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Antibody FenAb709 - fentanyl complex
分子名称: 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid, Antibody heavy chain, Antibody light chain
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2022-01-14
公開日2023-05-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Cell Rep, 42, 2023
7QT3
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Antibody FenAb609 - fentanyl complex
分子名称: Antibody heavy chain, Antibody light chain, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2022-01-14
公開日2023-05-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl.
Cell Rep, 42, 2023
8OK4
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Variant Surface Glycoprotein VSG11wt-Oil
分子名称: Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Stebbins, C.E, Aresta-Branco, F, Foti, K.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK5
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Variant Surface Glycoprotein VSG11 monomer with iodine
分子名称: IODIDE ION, Variant surface glycoprotein, alpha-D-glucopyranose, ...
著者Zeelen, J.P, Stebbins, C.E, Aresta-Branco, F.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
8OK6
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Variant Surface Glycoprotein VSG11 two monomers
分子名称: SULFATE ION, Variant surface glycoprotein, alpha-D-glucopyranose, ...
著者Gkeka, A, Vlachou, E.P, Zeelen, J.P, Stebbins, C.E.
登録日2023-03-27
公開日2023-09-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A structural classification of the variant surface glycoproteins of the African trypanosomey.
Plos Negl Trop Dis, 17, 2023
7AQY
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Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB11)
分子名称: Nanobody VSG2(NB11), Variant surface glycoprotein MITAT 1.2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Stebbins, C.E, Hempelmann, A, VanStraaten, M.
登録日2020-10-23
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021
7AQZ
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Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB14)
分子名称: CITRIC ACID, Nanobody VSG2(NB14), SODIUM ION, ...
著者Stebbins, C.E, Hempelmann, A, VanStraaten, M.
登録日2020-10-23
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021
6Z7C
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Variant Surface Glycoprotein VSGsur mutant H122A
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7B
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Variant Surface Glycoprotein VSGsur bound to suramin
分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E, Jeffrey, P.
登録日2020-05-30
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7E
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Variant Surface Glycoprotein VSGsur mutant H122A soaked in 7.7 mM suramin
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z7D
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Variant Surface Glycoprotein VSGsur mutant H122A soaked in 0.77 mM Suramin.
分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021
6Z79
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Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.
分子名称: 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zeelen, J.P, Straaten van, M, Stebbins, C.E.
登録日2020-05-30
公開日2021-03-17
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Nat Microbiol, 6, 2021

 

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