6Z7B

Variant Surface Glycoprotein VSGsur bound to suramin

Summary for 6Z7B

• Entry DOI: 10.2210/pdb6z7b/pdb
• Descriptor: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation vsg, membrane protein
• Biological source: Trypanosoma brucei rhodesiense
• Total number of polymer chains: 2
• Total formula weight: 109352.22

Authors

Zeelen, J.P.,Straaten van, M.,Stebbins, C.E.,Jeffrey, P. (deposition date: 2020-05-30, release date: 2021-03-24, Last modification date: 2024-01-24)

• Primary citation: Zeelen, J.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Halg, S.,Wiedemar, N.,Maser, P.,Papavasiliou, F.N.,Stebbins, C.E.; Structure of trypanosome coat protein VSGsur and function in suramin resistance.; Nat Microbiol, 6:392-400, 2021; PubMed: 33462435; DOI: 10.1038/s41564-020-00844-1

Experimental method

X-RAY DIFFRACTION (1.86 Å)