7P5A

Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) mutant (serine 317 to alanine), single O-linked glycosylated at Ser319

Summary for 7P5A

• Entry DOI: 10.2210/pdb7p5a/pdb
• Related: 6ELC 7P56 7P57 7P59 7P5B 7P5D
• Descriptor: Variant surface glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: variant surface glycoprotein, coat, trypanosoma brucei, o-glycosylation, o-glycans, immune evasion, african trypanosome, antigenic variation, post-translational modification, vsg, parasite, sleeping sickness, membrane protein
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 1
• Total formula weight: 55171.51

Authors

Gkeka, A.,Aresta-Branco, F.,Stebbins, C.E.,Papavasiliou, F.N. (deposition date: 2021-07-14, release date: 2022-07-27, Last modification date: 2024-02-07)

• Primary citation: Gkeka, A.,Aresta-Branco, F.,Triller, G.,Vlachou, E.P.,van Straaten, M.,Lilic, M.,Olinares, P.D.B.,Perez, K.,Chait, B.T.,Blatnik, R.,Ruppert, T.,Verdi, J.P.,Stebbins, C.E.,Papavasiliou, F.N.; Immunodominant surface epitopes power immune evasion in the African trypanosome.; Cell Rep, 42:112262-112262, 2023; PubMed: 36943866; DOI: 10.1016/j.celrep.2023.112262

Experimental method

X-RAY DIFFRACTION (1.95 Å)