4P76
 
 | | Cellular response to a crystal-forming protein | | 分子名称: | Photoconvertible fluorescent protein, SODIUM ION | | 著者 | Tsutsui, H, Jinno, Y, Shoda, K, Tomita, A, Matsuda, M, Yamashita, E, Katayama, H, Nakagawa, A, Miyawaki, A. | | 登録日 | 2014-03-26 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A diffraction-quality protein crystal processed as an autophagic cargo
Mol.Cell, 58, 2015
|
|
1XSS
 | | Semi-rational engineering of a green-emitting coral fluorescent protein into an efficient highlighter. | | 分子名称: | MAGNESIUM ION, SODIUM ION, fluorescent protein | | 著者 | Tsutsui, H, Karasawa, S, Shimizu, H, Nukina, N, Miyawaki, A. | | 登録日 | 2004-10-20 | | 公開日 | 2005-03-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Semi-rational engineering of a coral fluorescent protein into an efficient highlighter
Embo Rep., 6, 2005
|
|
2DDD
 | | Unique behavior of a histidine responsible for an engineered green-to-red photoconversion process | | 分子名称: | MAGNESIUM ION, SODIUM ION, photoconvertible fluorescent protein | | 著者 | Shimizu, H, Tsutsui, H, Nukina, N, Miyawaki, A. | | 登録日 | 2006-01-27 | | 公開日 | 2006-03-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins
Chem.Biol., 16, 2009
|
|
2DDC
 | | Unique behavior of a histidine responsible for an engineered green-to-red photoconversion process | | 分子名称: | MAGNESIUM ION, SODIUM ION, photoconvertible fluorescent protein | | 著者 | Shimizu, H, Tsutsui, H, Nukina, N, Miyawaki, A. | | 登録日 | 2006-01-27 | | 公開日 | 2006-03-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins.
Chem.Biol., 16, 2009
|
|
3AW0
 | | Structure of SARS 3CL protease with peptidic aldehyde inhibitor | | 分子名称: | 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-LEU-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3AW1
 | | Structure of SARS 3CL protease auto-proteolysis resistant mutant in the absent of inhibitor | | 分子名称: | 3C-Like Proteinase | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3ATW
 | | Structure-Based Design, Synthesis, Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors | | 分子名称: | 3C-Like Proteinase, peptide ACE-THR-VAL-ALC-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-01-20 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3AVZ
 | | Structure of SARS 3CL protease with peptidic aldehyde inhibitor containing cyclohexyl side chain | | 分子名称: | 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-ALC-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
1IU4
 | | Crystal Structure Analysis of the Microbial Transglutaminase | | 分子名称: | microbial transglutaminase | | 著者 | Kashiwagi, T, Yokoyama, K, Ishikawa, K, Ono, K, Ejima, D, Matsui, H, Suzuki, E. | | 登録日 | 2002-02-27 | | 公開日 | 2002-08-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of microbial transglutaminase from Streptoverticillium mobaraense
J.Biol.Chem., 277, 2002
|
|
6DCG
 | | Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology | | 分子名称: | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. | | 登録日 | 2018-05-06 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
|
|
2EK9
 | |
2EK8
 | |
6LVY
 | | Crystal structure of TLR7/Cpd-2 (SM-360320) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LW0
 | | Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LVZ
 | | Crystal structure of TLR7/Cpd-3 (SM-394830) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LVX
 | | Crystal structure of TLR7/Cpd-1 (SM-374527) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
6LW1
 | | Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | | 分子名称: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2020-02-06 | | 公開日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
|
|
4PF3
 | | Mineralocorticoid receptor ligand-binding domain with compuond 37a | | 分子名称: | 1,2-ETHANEDIOL, 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one, Mineralocorticoid receptor | | 著者 | Sogabe, S, Habuka, N. | | 登録日 | 2014-04-28 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists
Bioorg.Med.Chem., 22, 2014
|
|
1G0D
 | | CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE | | 分子名称: | PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE, SULFATE ION | | 著者 | Noguchi, K, Ishikawa, K, Yokoyama, K, Ohtsuka, T, Nio, N, Suzuki, E. | | 登録日 | 2000-10-06 | | 公開日 | 2001-05-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of red sea bream transglutaminase.
J.Biol.Chem., 276, 2001
|
|
8JL8
 | | Crystal structure of the collagen binding domain of Cnm from Streptococcus mutans | | 分子名称: | Collagen-binding adhesin, GLYCEROL, SULFATE ION | | 著者 | Tanaka, S.-i, Hirata, A, Takano, K. | | 登録日 | 2023-06-02 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans.
Chemistry, 5, 2023
|
|
3VW5
 | |
3WKH
 | | Crystal structure of cellobiose 2-epimerase in complex with epilactose | | 分子名称: | CHLORIDE ION, Cellobiose 2-epimerase, PHOSPHATE ION, ... | | 著者 | Fujiwara, T, Saburi, W, Tanaka, I, Yao, M. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.644 Å) | | 主引用文献 | Structural Insights into the Epimerization of beta-1,4-Linked Oligosaccharides Catalyzed by Cellobiose 2-Epimerase, the Sole Enzyme Epimerizing Non-anomeric Hydroxyl Groups of Unmodified Sugars
J.Biol.Chem., 289, 2014
|
|
3WY4
 | | Crystal structure of alpha-glucosidase mutant E271Q in complex with maltose | | 分子名称: | Alpha-glucosidase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Shen, X, Gai, Z, Kato, K, Yao, M. | | 登録日 | 2014-08-18 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural analysis of the alpha-glucosidase HaG provides new insights into substrate specificity and catalytic mechanism
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
|
|
3WKG
 | | Crystal structure of cellobiose 2-epimerase in complex with glucosylmannose | | 分子名称: | CHLORIDE ION, Cellobiose 2-epimerase, PHOSPHATE ION, ... | | 著者 | Fujiwara, T, Saburi, W, Tanaka, I, Yao, M. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Structural Insights into the Epimerization of beta-1,4-Linked Oligosaccharides Catalyzed by Cellobiose 2-Epimerase, the Sole Enzyme Epimerizing Non-anomeric Hydroxyl Groups of Unmodified Sugars
J.Biol.Chem., 289, 2014
|
|
3WKI
 | | Crystal structure of cellobiose 2-epimerase in complex with cellobiitol | | 分子名称: | CHLORIDE ION, Cellobiose 2-epimerase, PHOSPHATE ION, ... | | 著者 | Fujiwara, T, Saburi, W, Tanaka, I, Yao, M. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.191 Å) | | 主引用文献 | Structural Insights into the Epimerization of beta-1,4-Linked Oligosaccharides Catalyzed by Cellobiose 2-Epimerase, the Sole Enzyme Epimerizing Non-anomeric Hydroxyl Groups of Unmodified Sugars
J.Biol.Chem., 289, 2014
|
|
