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1ZRL
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BU of 1zrl by Molmil
Crystal structure of EBA-175 Region II (RII)
分子名称: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
著者Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
登録日2005-05-19
公開日2005-08-09
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
1ZRO
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BU of 1zro by Molmil
Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose
分子名称: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
著者Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
登録日2005-05-19
公開日2005-08-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
7K3Z
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BU of 7k3z by Molmil
P. falciparum Cpn60 D474A mutant bound to ATP
分子名称: 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Tolia, N.H, Shi, D, Nguyen, B.
登録日2020-09-14
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.69 Å)
主引用文献Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Sci Rep, 11, 2021
4QJB
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BU of 4qjb by Molmil
Crystal structure of the sugar phosphatase PfHAD1 from Plasmodium falciparum
分子名称: CHLORIDE ION, Haloacid dehalogenase-like hydrolase, MAGNESIUM ION
著者Tolia, N.H, Park, J.
登録日2014-06-03
公開日2014-07-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.
Nat Commun, 5, 2014
4NUU
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BU of 4nuu by Molmil
Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
分子名称: Duffy antigen/chemokine receptor, Duffy receptor
著者Tolia, N.H.
登録日2013-12-04
公開日2014-02-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
4NUV
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Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
分子名称: Duffy antigen/chemokine receptor, Duffy receptor, GLYCEROL
著者Tolia, N.H.
登録日2013-12-04
公開日2014-02-05
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
3RRC
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BU of 3rrc by Molmil
Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein
分子名称: 1,2-ETHANEDIOL, Duffy receptor, PHOSPHATE ION
著者Tolia, N.H.
登録日2011-04-29
公開日2011-07-13
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.
Nat.Struct.Mol.Biol., 18, 2011
4JNO
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Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL) Region II in complex with sialyllactose
分子名称: BAEBL protein, N-acetyl-alpha-neuraminic acid
著者Tolia, N.H.
登録日2013-03-15
公開日2013-03-27
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular Basis for Sialic Acid-dependent Receptor Recognition by the Plasmodium falciparum Invasion Protein Erythrocyte-binding Antigen-140/BAEBL.
J.Biol.Chem., 288, 2013
4K2U
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Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment
分子名称: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte binding antigen 175, ...
著者Tolia, N.H.
登録日2013-04-09
公開日2013-06-12
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
5TSZ
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BU of 5tsz by Molmil
Crystal structure of Plasmodium vivax CelTOS
分子名称: Pv cell-traversal protein, SODIUM ION
著者Tolia, N.H, Jimah, J.R.
登録日2016-10-31
公開日2016-12-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.
Elife, 5, 2016
6B2N
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BU of 6b2n by Molmil
Crystal structure of TEM-1 beta-lactamase mutant M182N
分子名称: Beta-lactamase TEM, SULFATE ION
著者Jimah, J.R, Tolia, N.H.
登録日2017-09-20
公開日2018-01-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
ACS Cent Sci, 3, 2017
8DCC
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BU of 8dcc by Molmil
SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 3 Bound to P2B-2F6 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, P2B-2F6 Fab heavy chain, P2B-2F6 Fab light chain, ...
著者Dickey, T.D, Tolia, N.H.
登録日2022-06-16
公開日2022-07-06
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
Sci Adv, 8, 2022
7U9E
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BU of 7u9e by Molmil
Pfs230 D1 domain in complex with 230AL-26
分子名称: 230AL-26, Gametocyte surface protein P230, LMIV230-01
著者Tang, W.K, Tolia, N.H.
登録日2022-03-10
公開日2023-02-15
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine.
Immunity, 56, 2023
6OAO
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BU of 6oao by Molmil
Structure of DBP in complex with human neutralizing antibody 092096
分子名称: Antibody 092096 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION
著者Urusova, D, Tolia, N.H.
登録日2019-03-18
公開日2019-06-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.497 Å)
主引用文献Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
9BJG
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Crystal structure of broadly neutralizing human monoclonal antibody 75B10 in complex with AMA1
分子名称: 75B10 Fab Heavy Chain, 75B10 Fab Light Chain, Apical membrane antigen 1
著者Patel, P.N, Tang, W.K, Tolia, N.H.
登録日2024-04-25
公開日2025-03-12
最終更新日2025-04-02
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.
Cell Rep Med, 6, 2025
9BJH
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Crystal structure of neutralizing human monoclonal antibody 75C8 in complex with AMA1 DI-DII
分子名称: 75C8 Fab Heavy Chain, 75C8 Fab Light Chain, Apical membrane antigen 1
著者Patel, P.N, Tang, W.K, Tolia, N.H.
登録日2024-04-25
公開日2025-03-12
最終更新日2025-04-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.
Cell Rep Med, 6, 2025
9DRH
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Crystal structure of Tet(X7) bound to anhydrotetracycline C10-benzoate ester
分子名称: (6aS,7S,10aS)-9-carbamoyl-7-(dimethylamino)-8,10a,12-trihydroxy-5-methyl-10,11-dioxo-6,6a,7,10,10a,11-hexahydrotetracen-1-yl pyrimidine-2-carboxylate, FLAVIN-ADENINE DINUCLEOTIDE, Tet(X7)
著者Tang, W.K, Tolia, N.H.
登録日2024-09-25
公開日2025-03-05
最終更新日2025-03-26
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity.
Acs Infect Dis., 11, 2025
6O38
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Structure of a chaperone-substrate complex
分子名称: Acinetobacter secreted protease CpaA, SULFATE ION, Type II secretion chaperone CpaB, ...
著者Urusova, D.V, Tolia, N.H.
登録日2019-02-26
公開日2019-07-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献The structure ofAcinetobacter-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction.
J.Biol.Chem., 294, 2019
6OAN
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Structure of DBP in complex with human neutralizing antibody 053054
分子名称: Antibody 053054 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION
著者Urusova, D, Tolia, N.H.
登録日2019-03-18
公開日2019-06-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
4QEX
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BU of 4qex by Molmil
Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217
分子名称: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte-binding antigen-175
著者Chen, E, Paing, M.M, Salinas, N, Sim, B.K, Tolia, N.H.
登録日2014-05-19
公開日2014-06-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (4.5 Å)
主引用文献Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
4YFS
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BU of 4yfs by Molmil
Structure of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for malaria vaccine design
分子名称: Duffy receptor
著者Chen, E, Tolia, N.H.
登録日2015-02-25
公開日2015-03-11
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design.
Plos Negl Trop Dis, 9, 2015
8EZL
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BU of 8ezl by Molmil
Pfs25 in complex with transmission-reducing antibody AS01-50
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ...
著者Shukla, N, Tang, W.K, Tolia, N.H.
登録日2022-11-01
公開日2023-08-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
8EZM
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Pfs25 in complex with transmission-reducing antibody AS01-63
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, SULFATE ION, ...
著者Shukla, N, Tang, W.K, Tolia, N.H.
登録日2022-11-01
公開日2023-08-16
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
8EZK
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Pfs25 in complex with transmission-reducing antibody AS01-04
分子名称: 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-4, single-chain Fv
著者Shukla, N, Tang, W.K, Tolia, N.H.
登録日2022-11-01
公開日2023-08-16
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
8GIF
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BU of 8gif by Molmil
Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 3
分子名称: Apical membrane antigen 1, rhoptry neck protein 2 chimera
著者Patel, P.N, Tolia, N.H.
登録日2023-03-14
公開日2023-08-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023

 

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