8CKF
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![BU of 8ckf by Molmil](/molmil-images/mine/8ckf) | Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand | 分子名称: | 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, Bromodomain-containing protein 4 | 著者 | Thomas, A.M, McDonough, M.A, Schiedel, M, Conway, S.J. | 登録日 | 2023-02-15 | 公開日 | 2023-08-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. Acs Chem.Biol., 18, 2023
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7ODA
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![BU of 7oda by Molmil](/molmil-images/mine/7oda) | OXA-48-like Beta-lactamase OXA-436 | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION | 著者 | Lund, B.A, Thomassen, A.M, Carlsen, T.J.W, Leiros, H.K.S. | 登録日 | 2021-04-29 | 公開日 | 2021-09-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. Acta Crystallogr.,Sect.F, 77, 2021
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6GOA
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![BU of 6goa by Molmil](/molmil-images/mine/6goa) | |
5OE0
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![BU of 5oe0 by Molmil](/molmil-images/mine/5oe0) | CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-181 | 分子名称: | Beta-lactamase, CHLORIDE ION, SULFATE ION | 著者 | Lund, B.A, Carlsen, T.J.O, Leiros, H.K.S, Thomassen, A.M. | 登録日 | 2017-07-07 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.0500083 Å) | 主引用文献 | Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallogr F Struct Biol Commun, 73, 2017
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6Q5B
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![BU of 6q5b by Molmil](/molmil-images/mine/6q5b) | OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, CARBON DIOXIDE, ... | 著者 | Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.K.S, Samuelsen, O. | 登録日 | 2018-12-07 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
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6Q5F
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![BU of 6q5f by Molmil](/molmil-images/mine/6q5f) | OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance | 分子名称: | 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Beta-lactamase, CHLORIDE ION, ... | 著者 | Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.-K.S, Samuelsen, O. | 登録日 | 2018-12-08 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
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5OE2
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![BU of 5oe2 by Molmil](/molmil-images/mine/5oe2) | CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245 | 分子名称: | Beta-lactamase, CHLORIDE ION, SODIUM ION | 著者 | Lund, B.A, Leiros, H.K.S. | 登録日 | 2017-07-07 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallogr F Struct Biol Commun, 73, 2017
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5ODZ
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![BU of 5odz by Molmil](/molmil-images/mine/5odz) | CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-163 | 分子名称: | Beta-lactamase, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Lund, B.A, Carlsen, T.J.O, Leiros, H.K.S. | 登録日 | 2017-07-07 | 公開日 | 2017-10-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallogr F Struct Biol Commun, 73, 2017
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5OFT
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![BU of 5oft by Molmil](/molmil-images/mine/5oft) | |
6SKQ
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![BU of 6skq by Molmil](/molmil-images/mine/6skq) | |
6SKP
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6SKR
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![BU of 6skr by Molmil](/molmil-images/mine/6skr) | OXA-10_ETP. Structural insight to the enhanced carbapenem efficiency of OXA-655 compared to OXA-10. | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, FORMIC ACID, ... | 著者 | Leiros, H.-K.S. | 登録日 | 2019-08-16 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. Febs Open Bio, 10, 2020
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