8E1Z
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8EZL
| Pfs25 in complex with transmission-reducing antibody AS01-50 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... | 著者 | Shukla, N, Tang, W.K, Tolia, N.H. | 登録日 | 2022-11-01 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A human antibody epitope map of the malaria vaccine antigen Pfs25. Npj Vaccines, 8, 2023
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8EZM
| Pfs25 in complex with transmission-reducing antibody AS01-63 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, SULFATE ION, ... | 著者 | Shukla, N, Tang, W.K, Tolia, N.H. | 登録日 | 2022-11-01 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A human antibody epitope map of the malaria vaccine antigen Pfs25. Npj Vaccines, 8, 2023
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8EZK
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9BKM
| DHODH in complex with Ligand 10 | 分子名称: | (2M,6P)-2-(2-chloro-6-fluorophenyl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-4-(propan-2-yl)isoquinolin-1(2H)-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Shaffer, P.L. | 登録日 | 2024-04-29 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. J.Med.Chem., 67, 2024
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9BKN
| DHODH in complex with Ligand 16 | 分子名称: | (2P,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-(propan-2-yl)isoquinolin-1(2H)-one, ACETATE ION, CHLORIDE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-04-29 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. J.Med.Chem., 67, 2024
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9BKO
| DHODH in complex with Ligand 26 | 分子名称: | (2P,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-[(2R)-1,1,1-trifluoropropan-2-yl]isoquinolin-1(2H)-one, ACETATE ION, CHLORIDE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-04-29 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. J.Med.Chem., 67, 2024
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9DHG
| DHODH in complex with Compound 5 | 分子名称: | (3P,7P)-7-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-6-fluoro-3-(2-methylphenyl)-1-(propan-2-yl)quinolin-4(1H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-09-03 | 公開日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.386 Å) | 主引用文献 | Identification of isoquinolinone DHODH inhibitor isosteres. Bioorg.Med.Chem.Lett., 2024
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9DHH
| DHODH in complex with Compound 8 | 分子名称: | (3S,7P)-7-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-6-fluoro-3-(2-methylphenyl)-1-(propan-2-yl)-2,3-dihydroquinolin-4(1H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-09-03 | 公開日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Identification of isoquinolinone DHODH inhibitor isosteres. Bioorg.Med.Chem.Lett., 2024
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9DHI
| DHODH in complex with Compound 7 | 分子名称: | (2M,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-(propan-2-yl)phthalazin-1(2H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-09-03 | 公開日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Identification of isoquinolinone DHODH inhibitor isosteres. Bioorg.Med.Chem.Lett., 2024
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9DHJ
| DHODH in complex with Compound 15 | 分子名称: | (2M,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-[(2R)-1,1,1-trifluoropropan-2-yl]phthalazin-1(2H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Shaffer, P.L. | 登録日 | 2024-09-03 | 公開日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Identification of isoquinolinone DHODH inhibitor isosteres. Bioorg.Med.Chem.Lett., 2024
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