5KKR
| KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 | 分子名称: | 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2 | 著者 | Dhawan, N.S, Scopton, A.P, Dar, A.C. | 登録日 | 2016-06-22 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.509 Å) | 主引用文献 | Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537, 2016
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7JUV
| Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... | 著者 | Khan, Z.M, Dar, A.C, Scopton, A.P. | 登録日 | 2020-08-20 | 公開日 | 2020-09-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | 主引用文献 | Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
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7JV1
| Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... | 著者 | Khan, Z.M, Dar, A.C, Scopton, A.P. | 登録日 | 2020-08-20 | 公開日 | 2020-09-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | 主引用文献 | Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
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7JUY
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7JUU
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7JUZ
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7JUT
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7JUS
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7JV0
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7JUW
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7JUQ
| Crystal Structure of KSR2:MEK1 in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... | 著者 | Khan, Z.M, Dar, A.C. | 登録日 | 2020-08-20 | 公開日 | 2020-09-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
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7JUR
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7JUX
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