2MJF
 
 | | Solution structure of the complex between the yeast Rsa1 and Hit1 proteins | | 分子名称: | Protein HIT1, Ribosome assembly 1 protein | | 著者 | Quinternet, M, Roth, B, Back, R, Jacquemin, C, Manival, X. | | 登録日 | 2014-01-08 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
Nucleic Acids Res., 42, 2014
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6HYK
 | | NMR solution structure of the C/D box snoRNA U14 | | 分子名称: | RNA (31-MER) | | 著者 | Chagot, M.E, Quinternet, M, Rothe, B, Charpentier, B, Coutant, J, Manival, X, Lebars, I. | | 登録日 | 2018-10-22 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution.
Biochimie, 164, 2019
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2LSV
 | | The NMR high resolution structure of yeast Tah1 in complex with the Hsp90 C-terminal tail | | 分子名称: | ATP-dependent molecular chaperone HSP82, TPR repeat-containing protein associated with Hsp90 | | 著者 | Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X. | | 登録日 | 2012-05-07 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex.
Structure, 21, 2013
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2LSU
 | | The NMR high resolution structure of yeast Tah1 in a free form | | 分子名称: | TPR repeat-containing protein associated with Hsp90 | | 著者 | Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X. | | 登録日 | 2012-05-07 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex.
Structure, 21, 2013
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4WGI
 | | A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) | | 分子名称: | (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, FORMIC ACID, MAGNESIUM ION, ... | | 著者 | Clifton, M.C, Fairman, J.W, Fang, C, D'Souza, B, Fulroth, B, Leed, A, McCarren, P, Wang, L, Wang, Y, Kaushik, V, Palmer, M, Wei, G, Golub, T.R, Hubbard, B.K, Serrano-Wu, M.H. | | 登録日 | 2014-09-18 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Acs Med.Chem.Lett., 5, 2014
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2JUM
 | | ThrA3-DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-08-31 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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2JUU
 | | allo-ThrA3 DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-09-03 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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2JUV
 | | AbaA3-DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-09-05 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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3GKY
 | | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | | 登録日 | 2009-03-11 | | 公開日 | 2009-03-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
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2M3F
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4RQN
 | | Crystal structure of the native BICC1 SAM Domain R924E mutant | | 分子名称: | Protein bicaudal C homolog 1, ZINC ION | | 著者 | Leettola, C.N, Cascio, D, Bowie, J.U. | | 登録日 | 2014-11-03 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Structure, 26, 2018
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4RQM
 | | Crystal structure of the SeMET BICC1 SAM Domain R924E mutant | | 分子名称: | Protein bicaudal C homolog 1, ZINC ION | | 著者 | Leettola, C.N, Cascio, D, Bowie, J.U. | | 登録日 | 2014-11-03 | | 公開日 | 2016-01-27 | | 最終更新日 | 2019-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Structure, 26, 2018
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7CMV
 | | Dopamine Receptor D3R-Gi-PD128907 complex | | 分子名称: | (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | | 登録日 | 2020-07-29 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-04-07 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structures of the human dopamine D3 receptor-G i complexes.
Mol.Cell, 81, 2021
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7CMU
 | | Dopamine Receptor D3R-Gi-Pramipexole complex | | 分子名称: | (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | | 登録日 | 2020-07-29 | | 公開日 | 2021-03-10 | | 最終更新日 | 2021-04-07 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of the human dopamine D3 receptor-G i complexes.
Mol.Cell, 81, 2021
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6WHA
 | | HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | | 分子名称: | 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Skiniotis, G, Roth, B, Kim, K, Panova, O. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
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7MVS
 | | DNA gyrase complexed with uncleaved DNA and Compound 7 to 2.6A resolution | | 分子名称: | (1S)-2-[(2r,5S)-5-{[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1,3-dioxan-2-yl]-1-(3-fluoro-6-methoxyquinolin-4-yl)ethan-1-ol, CHLORIDE ION, DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... | | 著者 | Ratigan, S.C, McElroy, C.A. | | 登録日 | 2021-05-15 | | 公開日 | 2021-10-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.60137153 Å) | | 主引用文献 | Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
J.Med.Chem., 64, 2021
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6PUS
 | | Human TRPM2 bound to ADPR and calcium | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6PUR
 | | Human TRPM2 bound to ADPR | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6PUU
 | | Human TRPM2 bound to 8-Br-cADPR and calcium | | 分子名称: | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6PUO
 | | Human TRPM2 in the apo state | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6NZ2
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6THL
 | | Crystal structure of the complex between RTT106 and BCD1 | | 分子名称: | Box C/D snoRNA protein 1, Rtt106p | | 著者 | Charron, C, Bragantini, B, Manival, X, Charpentier, B. | | 登録日 | 2019-11-20 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.
Nat Commun, 12, 2021
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5L85
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2N95
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2N94
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