5JNF
 
 | |
6EDK
 | | Crystal structure of the formyltransferase PseJ from Anoxybacillus kamchatkensis with N10-formyltetrahydrofolate | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Formyltransferase PseJ, N-{4-[{[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}(formyl)amino]benzoyl}-L-glutamic acid, ... | | 著者 | Reimer, J.M, Harb, I, Schmeing, T.M. | | 登録日 | 2018-08-09 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.
ACS Chem. Biol., 13, 2018
|
|
6MFW
 | | Crystal structure of a 4-domain construct of LgrA in the substrate donation state | | 分子名称: | (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-butanamide, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Linear gramicidin synthase subunit A, ... | | 著者 | Reimer, J.M, Eivaskhani, M, Schmeing, T.M. | | 登録日 | 2018-09-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
Science, 366, 2019
|
|
6MFY
 | | Crystal structure of a 5-domain construct of LgrA in the substrate donation state | | 分子名称: | 4'-PHOSPHOPANTETHEINE, Linear gramicidin synthase subunit A, PHOSPHATE ION | | 著者 | Reimer, J.M, Eivaskhani, M, Harb, I, Schmeing, T.M. | | 登録日 | 2018-09-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
Science, 366, 2019
|
|
6MFX
 | | Crystal structure of a 4-domain construct of a mutant of LgrA in the substrate donation state | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Linear gramicidin synthase subunit A, N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | | 著者 | Reimer, J.M, Eivaskhani, M, Schmeing, T.M. | | 登録日 | 2018-09-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
Science, 366, 2019
|
|
6MFZ
 | | Crystal structure of dimodular LgrA in a condensation state | | 分子名称: | 4'-PHOSPHOPANTETHEINE, Linear gramicidin synthase subunit A | | 著者 | Reimer, J.M, Eivaskhani, M, Harb, I, Schmeing, T.M. | | 登録日 | 2018-09-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
Science, 366, 2019
|
|
6CI5
 | | Crystal structure of the formyltransferase PseJ from Anoxybacillus kamchatkensis in complex with UDP-4,6-dideoxy-4-formamido-L-AltNAc and tetrahydrofolate | | 分子名称: | (2R,3R,4S,5R,6S)-3-(acetylamino)-5-(formylamino)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), N-[4-({[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, SULFATE ION, ... | | 著者 | Reimer, J.M, Harb, I, Schmeing, T.M. | | 登録日 | 2018-02-23 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.00003052 Å) | | 主引用文献 | Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.
ACS Chem. Biol., 13, 2018
|
|
6CI2
 | | Crystal structure of the formyltransferase PseJ from Anoxybacillus kamchatkensis | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, formyltransferase PseJ | | 著者 | Reimer, J.M, Jiang, J, Harb, I, Schmeing, T.M. | | 登録日 | 2018-02-23 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.
ACS Chem. Biol., 13, 2018
|
|
6MG0
 | | Crystal structure of a 5-domain construct of LgrA in the thiolation state | | 分子名称: | 5'-({[(2R,3R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-{[oxido(oxo)phosphonio]oxy}butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-4-methylpentyl]sulfonyl}amino)-5'-deoxyadenosine, Linear gramicidin synthase subunit A | | 著者 | Reimer, J.M, Eivaskhani, M, Harb, I, Schmeing, T.M. | | 登録日 | 2018-09-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
Science, 366, 2019
|
|
8DYV
 | | Structure of human cytoplasmic dynein-1 bound to one Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | 著者 | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | 登録日 | 2022-08-05 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
|
|
8DYU
 | | Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | 著者 | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | 登録日 | 2022-08-05 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
|
|
5ES8
 | |
5ES5
 | |
5ES6
 | |
5ES9
 | |
5ES7
 | | Crystal structure of the F-A domains of the LgrA initiation module soaked with FON, AMPcPP, and valine. | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Linear gramicidin synthetase subunit A, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... | | 著者 | Reimer, J.M, Aloise, M.N, Schmeing, T.M. | | 登録日 | 2015-11-16 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase.
Nature, 529, 2016
|
|
8E06
 | |
8E05
 | | Structure of dimeric LRRK1 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | | 著者 | Reimer, J.M, Lin, Y.X, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8E04
 | | Structure of monomeric LRRK1 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 | | 著者 | Reimer, J.M, Mathea, S, Chatterjee, D, Knapp, S, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of LRRK1 and mechanisms of autoinhibition and activation.
Nat.Struct.Mol.Biol., 30, 2023
|
|
6CI4
 | | Crystal structure of the formyltransferase PseJ from Anoxybacillus kamchatkensis soaked with UDP-4-amino-4,6-dideoxy-L-AltNAc | | 分子名称: | (2R,3R,4S,5R,6S)-3-(acetylamino)-5-amino-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, formyltransferase PseJ | | 著者 | Harb, I, Reimer, J.M, Schmeing, T.M. | | 登録日 | 2018-02-23 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.824068 Å) | | 主引用文献 | Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.
ACS Chem. Biol., 13, 2018
|
|
8DZZ
 | | Cryo-EM structure of chi dynein bound to Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
|
|
8E00
 | | Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
|
|
7MGM
 | | Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lahiri, I, Reimer, J.M, Leschziner, A.E. | | 登録日 | 2021-04-12 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Elife, 11, 2022
|
|
5D3K
 | | Crystal structure of the thioesterase domain of deoxyerythronolide B synthase | | 分子名称: | CALCIUM ION, Erythronolide synthase, modules 5 and 6, ... | | 著者 | Bergeret, F, Argyropoulos, P, Boddy, C.N, Schmeing, T.M. | | 登録日 | 2015-08-06 | | 公開日 | 2015-12-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.
Biochim.Biophys.Acta, 1860, 2015
|
|
5D3Z
 | | Crystal structure of the thioesterase domain of deoxyerythronolide B synthase in complex with a small phosphonate inhibitor | | 分子名称: | CALCIUM ION, Erythronolide synthase, modules 5 and 6, ... | | 著者 | Bergeret, F, Argyropoulos, P, Boddy, C.N, Schmeing, T.M. | | 登録日 | 2015-08-06 | | 公開日 | 2015-12-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.
Biochim.Biophys.Acta, 1860, 2015
|
|
