6MG0

Crystal structure of a 5-domain construct of LgrA in the thiolation state

Summary for 6MG0

Entry DOI	10.2210/pdb6mg0/pdb
Descriptor	Linear gramicidin synthase subunit A, 5'-({[(2R,3R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-{[oxido(oxo)phosphonio]oxy}butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-4-methylpentyl]sulfonyl}amino)-5'-deoxyadenosine (2 entities in total)
Functional Keywords	nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase
Biological source	Brevibacillus parabrevis
Total number of polymer chains	2
Total formula weight	393785.75
Authors	Reimer, J.M.,Eivaskhani, M.,Harb, I.,Schmeing, T.M. (deposition date: 2018-09-12, release date: 2019-11-20, Last modification date: 2023-10-11)
Primary citation	Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366:-, 2019 Cited by PubMed: 31699907 DOI: 10.1126/science.aaw4388 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (6 Å)

Structure validation